DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6700 and hpo-10

DIOPT Version :9

Sequence 1:	NP_001162944.1	Gene:	CG6700 / 34496	FlyBaseID:	FBgn0032305	Length:	874	Species:	Drosophila melanogaster
Sequence 2:	NP_498274.1	Gene:	hpo-10 / 175829	WormBaseID:	WBGene00017158	Length:	646	Species:	Caenorhabditis elegans

Alignment Length:	792	Identity:	230/792 - (29%)
Similarity:	325/792 - (41%)	Gaps:	223/792 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    66 QQQQVTSTVSTSNAPPGFSNALAA--PPPLPSGP--PPPPPPQIGQPPGQNKQQQQQQQQQQLQQ 126
            |...:.::.|..|.|..:......  |....|||  |||||    |....|...|....|.....
Worm    50 QNSWMNNSFSFPNPPSAYGQFGGGFHPSTWGSGPIVPPPPP----QQSAVNATAQAAYNQASFNY 110

  Fly   127 QQQQQQQQQQQQQKNFGGIRFNLNLNQKRLAGAPNPLQQQQQQQHQQQQHQQQQQVMQLYNNNNS 191
            ......|            .:|....:.|..||.|         ..|||..||.|...|...|||
Worm   111 APPPPPQ------------NWNNGYGRGRGGGANN---------WNQQQRPQQFQPFALNRKNNS 154

  Fly   192 NKKKRKRNNKNKNFEQSTYSNPFANQTPATPQAPPPPIISAS-DVGVPINPDLSKPPPPLPLAIV 255
            :                  :.|....|.......|.|::... ..|||. |..:|||||
Worm   155 S------------------AFPHLTSTFVPQGGGPQPLMGVGRGRGVPA-PGPAKPPPP------ 194

  Fly   256 APTENPQHQKQQQQEHMAAQRAGEATSQTSNFKRPNSFQMASSDSWPNSLNQYVARCYSKCNTDL 320
                             :|||                               |:.|.:...||..
Worm   195 -----------------SAQR-------------------------------YMERAFEAANTVE 211

  Fly   321 DKDQIDICLKGKIIAAANRNELWTRDWDNEPMPTVYSERDGIDVVLSNVPPPQQQRSNYFQKKQE 385
            |:.:....|:.::....|.......:|||||:|
Worm   212 DRQKTQEYLQKRLFPMLNAGNAHMVNWDNEPLP-------------------------------- 244

  Fly   386 QERERERDREADKSPAKGSTGIVNQFKQKGNQFNKASSSYGSHHSSSSKYSRSRSRSPSSSNSLK 450
              .|:..:.....:||       |:...:.|.||:             |.|.||.||...|||..
Worm   245 --HEKNYELAPAWTPA-------NKLPHQANGFNR-------------KKSPSRRRSDEMSNSGA 287

  Fly   451 YSSKKRYSRSRSRSRSRSRSPRSRSCSRSSDASSPPARKIIRKSGSNESLNFIPLTANLSRKQQK 515
            .....:..|:|.         .|...|..||.|.|           .|.::|    :::::|:.|
Worm   288 AGGGGQMKRARR---------DSDGASSDSDNSDP-----------LEKMHF----SSMNQKKTK 328

  Fly   516 MLMKKGKRAAAMASAQMKKKDTPHFYSNQSSVGGAVDDDTARLQQRAARFSQQGSSSAKKSVVAI 580
             ..||.::||..|:.:::|:.||....|...|.|.  |..||.:.||.||::...:.:|.||
Worm   329 -AQKKAEKAARKAAKKLQKQQTPQKVKNAWKVAGG--DTEARREDRARRFAETLYNVSKPSV--- 387

  Fly   581 ASSPFGLTTAKNKKKMVQQHQQHQRSAFYEDTEAASGIDLLDLHIVGTCRDLEKSFLRLTKAPSP 645
                           .|.||...:...                 |.|||:::||||.|||.||:|
Worm   388 ---------------SVPQHYFRRGQV-----------------IRGTCQNIEKSFFRLTAAPNP 420

  Fly   646 SEVRPVEVLTHSLVNVKGKWRANQDYHYACDQLKSIRQDLTVQGIRDQFTVEVYETHARIAMEKG 710
            |||||:|||..||.||:.|:||..:|.|...|::|||||||||.||::|||||||.:|||::|..
Worm   421 SEVRPLEVLRLSLQNVRDKYRARAEYSYLTSQMRSIRQDLTVQVIRNEFTVEVYEINARISLENA 485

  Fly   711 DHEEFNQCQTQLKMLYMEIGGKN-ANALEFTAYRILYYIFTKNTLDITTVMRSITADQRENPVIA 774
            |.||||:||:|||:||.||  :| ||..||.|||:||||...|.:||..::|.:|.:.:||..:.
Worm   486 DREEFNKCQSQLKLLYSEI--ENCANQAEFVAYRLLYYIAMDNQIDINALLRELTPELKENDCVE 548

  Fly   775 HALQFRSAWSLGNYCKLFSLYRTAPLMSGHMIEWFLERERKAALRVIIKSYRPNISVDYITKILA 839
            .||..|.|.::.||.|.|.|::.||.|..::::.|::||||.||.:|.|::||.|:...|.:.|:
Worm   549 FALNVRKAVTMNNYVKFFRLFKNAPRMCPYIMDLFVDRERKKALGIITKAFRPTITYKLIAEFLS 613

  Fly   840 FDSSEKCKEWLD 851
            ...|... :||:
Worm   614 MKESTLI-DWLE 624

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6700	NP_001162944.1	SAC3_GANP	643..840	CDD:281402	101/197 (51%)
hpo-10	NP_498274.1	SAC3_GANP	418..612	CDD:281402	100/195 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	204	1.000	Domainoid score	I1728
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	253	1.000	Inparanoid score	I1977
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003794
OrthoInspector	1	1.000	-	-		oto18370
orthoMCL	1	0.900	-	-		OOG6_101802
Panther	1	1.100	-	-	LDO	PTHR12436
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1512
SonicParanoid	1	1.000	-	-		X3733
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.990