DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6700 and leng8

DIOPT Version :9

Sequence 1:	NP_001162944.1	Gene:	CG6700 / 34496	FlyBaseID:	FBgn0032305	Length:	874	Species:	Drosophila melanogaster
Sequence 2:	NP_001082988.1	Gene:	leng8 / 100037367	ZFINID:	ZDB-GENE-070410-6	Length:	839	Species:	Danio rerio

Alignment Length:	957	Identity:	303/957 - (31%)
Similarity:	419/957 - (43%)	Gaps:	250/957 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 PQLQEMQQ------QQQQSANPA--QLAQQWSNYAWYANQNAAYQQQYQQYYQYYVRYQQQQQQQ 69
            |:.::.:|      :.|.|..|:  |..||...|......::|.||  |||||.:  |||.|||.
Zfish    30 PEWEKARQALASISKSQNSTKPSTNQTTQQAGQYQAAVTDSSAMQQ--QQYYQQW--YQQNQQQY 90

  Fly    70 V-------------------------------TSTVSTSNAP--PGFSNALAAPPPLP------- 94
            .                               |.|..|..||  |...:..:..||.|
Zfish    91 AGYPYPYNYYYPMPPYGGPYPPGQYGVPGGYQTPTTPTGQAPSMPTMEDQSSNYPPQPPPPATPQ 155

  Fly    95 ---------SGPPPPPPPQIGQPPGQNKQQQQQQQQQQLQQQQQQQQQQQQQQQKNFGGIRFNLN 150
                     ..|||||||.|  ||..|.|..:...|......               |.:.::..
Zfish   156 PPPQSPTSSDQPPPPPPPPI--PPQPNAQYPRPPSQTPYSPN---------------GVLPYSPT 203

  Fly   151 LNQKRLAGAPNPLQQQQQQQHQQ----QQHQQQQQVMQLYNN-NNSNKKKRKRNNKNKNFEQSTY 210
            .:...:.|. ||.|.:...|..|    |.||||.....||.. ...:.||...:|.||..:|...
Zfish   204 DSNPMMRGY-NPGQIRPGYQGYQTPVYQPHQQQAPAPGLYGGAGRVDAKKPNNSNMNKGGQQLWQ 267

  Fly   211 SNPFANQTPATPQAPPPPIISASDVGVPINP----DLSKPPPPLPLAIVAPT-ENPQHQKQQQQE 270
            .   ..|.|.|         .|....:|..|    :.:.||......:..|| .||......
Zfish   268 R---MKQAPGT---------GAVKFNIPKRPYVMSNQNFPPGEQGPGLAPPTATNPSSGSTS--- 317

  Fly   271 HMAAQRAGEATSQTSNFKRPNSFQMASSDSWPNSLNQYVARCYSKCNTDLDKDQIDICLKGKIIA 335
              |...|....:||    ||        ..||.::.:||.||::.|.::.|||:.:..||..:.:
Zfish   318 --ATSSASTGGAQT----RP--------QDWPQAMKEYVQRCFTACESEEDKDRTEKMLKDLLQS 368

  Fly   336 AANRNELWTRDWDNEPMPTVYSERDGIDVVLSNVPPPQQQRSNYFQKKQEQERERERDREADKSP 400
            .......:|.||:.||:|.:..::...:|:      ||..:.|...:             ...:.
Zfish   369 RLQDGSAYTIDWNREPLPDLKPKQSRWEVM------PQLSQENSIGR-------------GGATR 414

  Fly   401 AKGSTGIVNQFKQKGNQFNKASSSYGSHHSSSSKYSRSRSRSPSSSNSLKYSSKKRYSRSRSRSR 465
            .:|...:.|.    .|.|::.|.|     ||||..|||.|||||               ..||.|
Zfish   415 GRGGARLGNY----RNVFSQRSPS-----SSSSGSSRSSSRSPS---------------PHSRHR 455

  Fly   466 SRSRSPRSRSCSRSSDASSPPARKIIRKSGSNESLNFIPLTANLSRKQQK------MLMKKGKRA 524
            .|||..||.|.|:|..:.|...|                  .:|:|:|||      ...::|:.|
Zfish   456 DRSRHHRSDSGSQSDGSMSSDLR------------------LSLTRRQQKGGRGRGAERERGRGA 502

  Fly   525 AA------------------MASAQMKKKDTPHFYSNQSSVGGAVDDD------TARLQQRAARF 565
            |.                  :||...||:.           ||....|      .|:.|.|||||
Zfish   503 AGERGRGRGKANRGRRNMEDLASGVGKKRK-----------GGNAGLDFHDPNREAKKQSRAARF 556

  Fly   566 SQQGSSSAKKSVVAIASSPFGLTTAKNKKKMVQQHQQHQRSAFYEDTEAASGIDLLDLHIVGTCR 630
            ..:           :.:.|..|..                :.|........|:...|..|||||:
Zfish   557 HTK-----------LRTEPLVLNI----------------NVFDLPNGTQEGLSWDDCPIVGTCQ 594

  Fly   631 DLEKSFLRLTKAPSPSEVRPVEVLTHSLVNVKGKWRANQDYHYACDQLKSIRQDLTVQGIRDQFT 695
            |:.|::||||.||.||.||||.||..||:.||..|::||||.|||:|:|||||||||||:|..||
Zfish   595 DITKNYLRLTCAPDPSTVRPVPVLRKSLIAVKAHWKSNQDYVYACEQMKSIRQDLTVQGVRTDFT 659

  Fly   696 VEVYETHARIAMEKGDHEEFNQCQTQLKMLYMEIGGKNANALEFTAYRILYYIFTKNTLDITTVM 760
            |||||||||||:||||||||||||||||.||.:....|..  ||||||::|||||||:.|:||.:
Zfish   660 VEVYETHARIALEKGDHEEFNQCQTQLKALYKDCPSDNVG--EFTAYRLIYYIFTKNSGDLTTEL 722

  Fly   761 RSITADQRENPVIAHALQFRSAWSLGNYCKLFSLYRTAPLMSGHMIEWFLERERKAALRVIIKSY 825
            ..:|.:.|.:|.:||||:.|:||:|||:.:.|.||:.||.|:.::|:.|:||||..|||.|:||:
Zfish   723 VYLTTELRADPCVAHALELRTAWALGNFHRFFRLYQKAPRMAAYLIDKFVERERNIALRAILKSF 787

  Fly   826 RPNISVDYITKILAFDSSEKCKEWLDTFSLPYA-ADGAQVDCKNAAA 871
            ||::||:|:...|||...:.|..:|....:.:. :|.:::|||.::|
Zfish   788 RPSVSVEYVQSSLAFPDLDTCLAFLTGLGISFTPSDPSKIDCKVSSA 834

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6700	NP_001162944.1	SAC3_GANP	643..840	CDD:281402	119/196 (61%)
leng8	NP_001082988.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..75		10/44 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	106..262		41/173 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	287..332		12/61 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	400..553		50/218 (23%)
		SAC3_GANP	607..802	CDD:281402	119/196 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	262	1.000	Domainoid score	I1911
eggNOG	1	0.900	-	-		E1_KOG1861
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	362	1.000	Inparanoid score	I2150
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1503267at2759
OrthoFinder	1	1.000	-	-		FOG0003794
OrthoInspector	1	1.000	-	-		oto40254
orthoMCL	1	0.900	-	-		OOG6_101802
Panther	1	1.100	-	-	LDO	PTHR12436
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1512
SonicParanoid	1	1.000	-	-		X3733
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	12	11.950