DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nos and pora

DIOPT Version :9

Sequence 1:	NP_523541.2	Gene:	Nos / 34495	FlyBaseID:	FBgn0011676	Length:	1349	Species:	Drosophila melanogaster
Sequence 2:	NP_001030154.1	Gene:	pora / 568202	ZFINID:	ZDB-GENE-050809-121	Length:	674	Species:	Danio rerio

Alignment Length:	724	Identity:	191/724 - (26%)
Similarity:	316/724 - (43%)	Gaps:	150/724 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   647 FKQIARAVKFTSKLFGRALSKRIKAT-----VLYATETGKSEQYAKQLCELLGHAFNAQIYCM-- 704
            |..:...::.||.:      :::|.|     |.|.::||..|::|.:|.:      :|..|.|
Zfish    54 FTLVTAPIRETSFI------EKMKKTNRSVVVFYGSQTGTGEEFANRLSK------DAHRYGMKG 106

  Fly   705 -----SDYDISSIEH-----EALLIVVASTFGNGDPPENGELFSQELYAMRVQESSEHGLQDSSI 759
                 .:||:|.:..     :::.:...:|:|.|||.:|.
Zfish   107 MAADPEEYDMSELSRLKEIPKSMAVFCMATYGEGDPTDNA------------------------- 146

  Fly   760 GSSKSFMKASSRQEFMKLPLQQVKRIDRWDSLRGSTSDTFTEETFGPLSNVRFAVFALGSSAYPN 824
                        |||             :|.|:|:..|         |..|.||||.||:..|.:
Zfish   147 ------------QEF-------------YDWLQGTDDD---------LEGVNFAVFGLGNKTYEH 177

  Fly   825 FCAFGQYVDNILGELGGERLLRVAYGDEMCGQEQSFRKWAPEVFKLACETFCLD---PEESLSDA 886
            :.|.|:|.|..|.||||:|:..:..||:....|:.|..|..:.:...||.|.::   .:.|:...
Zfish   178 YNAMGKYTDKRLAELGGKRVFDLGLGDDDSNLEEDFISWKEQFWPAVCEYFGVEATGEDSSIRQF 242

  Fly   887 SLALQNDSLTVNTVRLVPSANKGSLDSSLSKYHNKKVHCCKAKAKPHNLTRLSEGAKTTML---L 948
            .|.:.|| :.:|.|.........|..:....:..|..........    .:|::|....::   |
Zfish   243 ELVVHND-INMNQVYTGEMGRLKSFQTQKPPFDAKNPFLASVAVN----RKLNKGGNRHLMHIEL 302

  Fly   949 EICAPGLEYEPGDHVGIFPANRTELVDGLLNRLVGVDNPDEVLQLQLLKEKQTSNGIFKCWEPHD 1013
            :|....:.|:.||||.::|.|.:.:|:.:..|| ||| .|.|:.|:.|.|:......|.|
Zfish   303 DITESKIRYDSGDHVAVYPTNDSAMVNRIGERL-GVD-LDAVISLKNLDEESNKKHPFPC----- 360

  Fly  1014 KIPPDTLRNLLARFFDLTTPPSRQLLTLLAGFCEDTADKERLELLVNDS----SAYEDWRHWRLP 1074
               |.|.|..|..:.|:...|...:|..||.:..|..::|.:..:.:.|    :.|:.|......
Zfish   361 ---PTTYRTALTHYLDINNMPRTNVLYELAQYASDPQEQENMRKMASASPEGKALYQSWVLDSER 422

  Fly  1075 HLLDVLEEFPSCRPPAPLLLAQLTPLQPRFYSISSSPRRVSDEIHLTVAIVKYRCEDGQGDERYG 1139
            ::|.:||:.||..||...|...|..||.|:|||:||.:.....||:...:::|..:.|:..:  |
Zfish   423 NILAILEDLPSLNPPIDHLCELLPRLQARYYSIASSSKVHPHCIHICAVVIEYNTKTGRVFK--G 485

  Fly  1140 VCSNYLSGLRADDE-----LFMFVRSALGFHLPSDRSRPIILIGPGTGIAPFRSFWQEFQVLSDL 1199
            |.:|:|.|....|.     :.|:||.: .|.||...|.|:|:||||||||||..|.||
Zfish   486 VATNWLKGKHVTDNGHKPTVPMYVRRS-QFRLPFKPSNPVIMIGPGTGIAPFMGFIQE------- 542

  Fly  1200 DPTAKLPKMW------------LFFGCRNRDVD-LYAEEKAELQKDQILDRVFLALSREQAIPKT 1251
                   :.|            |:||||:.:.| ||.:|..|.::..:|.::.:|.||:|. .|.
Zfish   543 -------RAWRKEQGKDVGETILYFGCRHSNEDFLYQQELEEFERAGVLTQLNVAFSRDQE-QKV 599

  Fly  1252 YVQDLIEQEFDSLYQLIVQERGHIYVCGDV-TMAEHVYQTIRKCIAGKEQKSEAEVETFLLTLRD 1315
            |||.|:::....|::||..:..|||||||. .||..|:....:....:.:.:..:...:...|..
Zfish   600 YVQHLLKKNKQQLWKLIHTDNAHIYVCGDARNMARDVHAAFSEIAEQEGRLTHTQALDYFKKLMT 664

  Fly  1316 ESRYHEDIF 1324
            :.||.:|::
Zfish   665 KGRYSQDVW 673

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nos	NP_523541.2	NOS_oxygenase_euk	216..624	CDD:238410
		CysJ	669..1323	CDD:223446	187/699 (27%)
		Flavodoxin_1	673..863	CDD:278677	49/201 (24%)
		Nitric_oxide_synthase	931..1328	CDD:99799	125/420 (30%)
pora	NP_001030154.1	CysJ	56..673	CDD:223446	190/720 (26%)
		Flavodoxin_1	79..216	CDD:278677	49/201 (24%)
		NADB_Rossmann	<212..234	CDD:304358	5/21 (24%)
		CYPOR	274..673	CDD:99801	126/430 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910