DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nos and mtrr

DIOPT Version :9

Sequence 1:	NP_523541.2	Gene:	Nos / 34495	FlyBaseID:	FBgn0011676	Length:	1349	Species:	Drosophila melanogaster
Sequence 2:	NP_001373459.1	Gene:	mtrr / 560667	ZFINID:	ZDB-GENE-101115-3	Length:	697	Species:	Danio rerio

Alignment Length:	751	Identity:	193/751 - (25%)
Similarity:	323/751 - (43%)	Gaps:	164/751 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   673 VLYATETGKSEQYAKQLCELLG-HAFNAQIYCMSDYDISSIEHEALLIV-VASTFGNGDPPENGE 735
            :||.::.|:::..|:::|:... |.|.|.|.|:|.:|..:::.|:..:| |.||.|:||||:...
Zfish    11 ILYGSQRGQAQSIAEEICQQAAEHGFTADISCLSKHDKYNLDSESRPVVFVVSTTGDGDPPDTAL 75

  Fly   736 LFSQELYAMRVQESSEHGLQDSSIGSSKSFMKASSRQEFMKLPLQQVKRIDRWDSLRGSTSDTFT 800
            .|.:::                   .:||            ||...
Zfish    76 KFVRKI-------------------KNKS------------LPHDH------------------- 90

  Fly   801 EETFGPLSNVRFAVFALGSSAYPNFCAFGQYVDNILGELGGERLLRVAYGDEMCGQEQSFRKWAP 865
                  ||::|:|:..||.:.|.|||..|:.:|:.|.:||.:......:.|:..|.|.....|..
Zfish    91 ------LSHLRYALLGLGDTNYANFCNGGKTIDSYLQKLGAKHFYATGHADDGTGLEVVVDPWIE 149

  Fly   866 ---EVFKLACETFCLDPEESLSDAS----------------LALQ----------------NDSL 895
               :..|.|..|.....:::|||.:                :.||                :||:
Zfish   150 GLWDALKKAFSTMSTSDQQTLSDCTQDSNHQNASDQKKNLEVDLQLLKLSEVDSPKGKTVTSDSI 214

  Fly   896 TV-------------------NTVRLVPSANKGSLDSSLSKYHNKKVHCCKAK--------AKPH 933
            ..                   .:|..||:.....|:..|....|.:......|        :|..
Zfish   215 ATEIGSTSSVASLKESVPPLSESVLNVPALPPSYLEILLVGTENVEETVLPDKDGYFEVPISKAV 279

  Fly   934 NLTRLSEGAKTTMLLEICAPGLE---YEPGDHVGIFPANRTELVDGLLNRLVGVDNPDEVLQLQL 995
            .||: .:..||.:|||:.....:   |:|||...|...||...|:.||.:|......:..:|:.|
Zfish   280 QLTQ-DDAVKTAILLELDISQQQEQVYQPGDAFDILCPNRDSEVEELLLKLDLQMQKNCTVQVNL 343

  Fly   996 LKEKQTSNGIFKCWEPHDKIPPD-TLRNLLARFFDLTTPPSRQLLTLLAGFCEDTADKER-LELL 1058
            |  |.||.   |..:....||.: :|:.:|....::.:.|.:..|..|..|.::.::|.| |||.
Zfish   344 L--KNTSK---KAAKVPLHIPQNGSLQFILTWCLEIRSTPKKAFLRALVDFTQNASEKRRLLELC 403

  Fly  1059 VNDSSA-YEDWRHWRLPHLLDVLEEFPSCRPPAPLLLAQLTPLQPRFYSISSSPRRVSDEIHLTV 1122
            ....|| |..:.......:||:|..||||.||..||...|..||||.||.:||..:...::||..
Zfish   404 SKQGSADYNSFVRDSSVCVLDLLRAFPSCCPPLSLLFEHLPKLQPRAYSAASSSLQHPGKVHLVF 468

  Fly  1123 AIVKYRCEDGQGDERYGVCSNYL-------------------SGLRADDELFMFVRSALGFHLPS 1168
            .:|::.... :...|.|:|:.:|                   .|..|..::.:..|.:..|||||
Zfish   469 NVVEFPARP-EHPARKGLCTGWLVDHVSSILEPHGTALASERPGTSALPKVHVRARPSSTFHLPS 532

  Fly  1169 DRSRPIILIGPGTGIAPFRSFWQEFQVLSDLDPTAKLPKMWLFFGCRNRDVD-LYAEEKAELQKD 1232
            |...|::::|||||:|||..|.|:.:...:.:..|...:||||||||::|.| |:.||..:...:
Zfish   533 DPCVPVVMVGPGTGVAPFIGFLQQREKEREANQEATFGEMWLFFGCRHKDKDFLFREELEKFVHN 597

  Fly  1233 QILDRVFLALSREQAIP--------KTYVQDLIEQEFDSLYQLIVQERGHIYVCGDV-TMAEHVY 1288
            ..|..:.:..||::  |        .||||..:.....:|.:::::::|.:|||||. .||:.|.
Zfish   598 GTLSHLIVCFSRDE--PDAAETVNRPTYVQHNLILHAKNLAKILLEDKGCLYVCGDAKNMAKDVN 660

  Fly  1289 QTIRKCIAGKEQKSEAEVETFLLTLRDESRYHEDIF 1324
            .|:.:.|..:.|..:.:....:..||::.||.:||:
Zfish   661 DTLLEIIGNELQLDKLDAMKIVAGLREDKRYLQDIW 696

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nos	NP_523541.2	NOS_oxygenase_euk	216..624	CDD:238410
		CysJ	669..1323	CDD:223446	191/748 (26%)
		Flavodoxin_1	673..863	CDD:278677	45/191 (24%)
		Nitric_oxide_synthase	931..1328	CDD:99799	130/429 (30%)
mtrr	NP_001373459.1	Flavodoxin_1	11..147	CDD:395199	45/191 (24%)
mtrr	NP_001373459.1	methionine_synthase_red	274..696	CDD:99800	129/430 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910