DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nos and POR

DIOPT Version :9

Sequence 1:	NP_523541.2	Gene:	Nos / 34495	FlyBaseID:	FBgn0011676	Length:	1349	Species:	Drosophila melanogaster
Sequence 2:	NP_001369584.2	Gene:	POR / 5447	HGNCID:	9208	Length:	695	Species:	Homo sapiens

Alignment Length:	721	Identity:	204/721 - (28%)
Similarity:	325/721 - (45%)	Gaps:	158/721 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   657 TSKLFGRALSKRIKAT-----VLYATETGKSEQYAKQLCELLGHAFNAQIYCM-------SDYDI 709
            ||.:...:..:::|.|     |.|.::||.:|::|.:|.:      :|..|.|       .:||:
Human    79 TSSVRESSFVEKMKKTGRNIIVFYGSQTGTAEEFANRLSK------DAHRYGMRGMSADPEEYDL 137

  Fly   710 SSIE-----HEALLIVVASTFGNGDPPENGELFSQELYAMRVQESSEHGLQDSSIGSSKSFMKAS 769
            :.:.     ..||::...:|:|.|||.:|    :|:.|
Human   138 ADLSSLPEIDNALVVFCMATYGEGDPTDN----AQDFY--------------------------- 171

  Fly   770 SRQEFMKLPLQQVKRIDRWDSLRGSTSDTFTEETFGPLSNVRFAVFALGSSAYPNFCAFGQYVDN 834
                                        .:.:||...||.|:||||.||:..|.:|.|.|:|||.
Human   172 ----------------------------DWLQETDVDLSGVKFAVFGLGNKTYEHFNAMGKYVDK 208

  Fly   835 ILGELGGERLLRVAYGDEMCGQEQSFRKWAPEVFKLACETFCLDP--EESLSDASLALQNDSLTV 897
            .|.:||.:|:..:..||:....|:.|..|..:.:...||.|.::.  |||      :::...|.|
Human   209 RLEQLGAQRIFELGLGDDDGNLEEDFITWREQFWPAVCEHFGVEATGEES------SIRQYELVV 267

  Fly   898 NTVRLVPSANKGSLDSSLSKYHNKKVHCCKAKAKPHNLT------RLSEGAKTTML---LEICAP 953
            :|.........|.: ..|..|.|:|.   ...||...|.      :|::|.:..::   |:|...
Human   268 HTDIDAAKVYMGEM-GRLKSYENQKP---PFDAKNPFLAAVTTNRKLNQGTERHLMHLELDISDS 328

  Fly   954 GLEYEPGDHVGIFPANRTELVDGLLNRLVGVDNPDEVLQLQLLKEKQTSNGIFKCWEPHDKIPPD 1018
            .:.||.||||.::|||.:.||: .|.:::|.| .|.|:.|..|.|:......|.|        |.
Human   329 KIRYESGDHVAVYPANDSALVN-QLGKILGAD-LDVVMSLNNLDEESNKKHPFPC--------PT 383

  Fly  1019 TLRNLLARFFDLTTPPSRQLLTLLAGFCEDTADKERLELLVNDS----SAYEDWRHWRLPHLLDV 1079
            :.|..|..:.|:|.||...:|..||.:..:.:::|.|..:.:.|    ..|..|......|:|.:
Human   384 SYRTALTYYLDITNPPRTNVLYELAQYASEPSEQELLRKMASSSGEGKELYLSWVVEARRHILAI 448

  Fly  1080 LEEFPSCRPPAPLLLAQLTPLQPRFYSISSSPRRVSDEIHLTVAIVKYRCEDGQGDERYGVCSNY 1144
            |::.||.|||...|...|..||.|:|||:||.:...:.:|:...:|:|..:.|:.::  ||.:|:
Human   449 LQDCPSLRPPIDHLCELLPRLQARYYSIASSSKVHPNSVHICAVVVEYETKAGRINK--GVATNW 511

  Fly  1145 LSGLRADDE------LFMFVRSALGFHLPSDRSRPIILIGPGTGIAPFRSFWQEFQVLSDLDPTA 1203
            |.......|      :.||||.: .|.||...:.|:|::|||||:|||..|.||
Human   512 LRAKEPAGENGGRALVPMFVRKS-QFRLPFKATTPVIMVGPGTGVAPFIGFIQE----------- 564

  Fly  1204 KLPKMW------------LFFGCRNRDVD-LYAEEKAELQKDQILDRVFLALSREQAIPKTYVQD 1255
               :.|            |::|||..|.| ||.||.|:..:|..|.::.:|.||||: .|.|||.
Human   565 ---RAWLRQQGKEVGETLLYYGCRRSDEDYLYREELAQFHRDGALTQLNVAFSREQS-HKVYVQH 625

  Fly  1256 LIEQEFDSLYQLIVQERG-HIYVCGDV-TMAEHVYQTIRKCIAGKEQKSEAEVETFLLTLRDESR 1318
            |::|:.:.|::||  |.| |||||||. .||..|..|....:|.......|:...::..|..:.|
Human   626 LLKQDREHLWKLI--EGGAHIYVCGDARNMARDVQNTFYDIVAELGAMEHAQAVDYIKKLMTKGR 688

  Fly  1319 YHEDIF 1324
            |..|::
Human   689 YSLDVW 694

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nos	NP_523541.2	NOS_oxygenase_euk	216..624	CDD:238410
		CysJ	669..1323	CDD:223446	201/706 (28%)
		Flavodoxin_1	673..863	CDD:278677	48/201 (24%)
		Nitric_oxide_synthase	931..1328	CDD:99799	136/428 (32%)
POR	NP_001369584.2	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910