DRSC/TRiP Functional Genomics Resources

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Protein Alignment Nos and NOS1

DIOPT Version :9

Sequence 1:NP_523541.2 Gene:Nos / 34495 FlyBaseID:FBgn0011676 Length:1349 Species:Drosophila melanogaster
Sequence 2:NP_001191147.1 Gene:NOS1 / 4842 HGNCID:7872 Length:1468 Species:Homo sapiens


Alignment Length:1403 Identity:620/1403 - (44%)
Similarity:832/1403 - (59%) Gaps:169/1403 - (12%)


- Green bases have known domain annotations that are detailed below.


  Fly    58 TQATPTLNGNGL------------------LSGNPNGG-----------GGDSSPSHEVDHPGGA 93
            |....|..|:|.                  ||..|..|           |..:.|.|..|     
Human   105 THLETTFTGDGTPKTIRVTQPLGPPTKAVDLSHQPPAGKEQPLAVDGASGPGNGPQHAYD----- 164

  Fly    94 QGAQAAGGLPSSSGTPLRHHKRASISTASPPIRERRGTNTSIVVELDGSGSGSGSGGGGVGVGQG 158
             ..|.||.||.::|...|...:.....|:....:.||.|..::.|::...|...||..||    .
Human   165 -DGQEAGSLPHANGLAPRPPGQDPAKKATRVSLQGRGENNELLKEIEPVLSLLTSGSRGV----K 224

  Fly   159 AGCPPSGSC---------TASGKSSRELSPSPKN-----------------------QQQPRKMS 191
            .|.|.....         ...|||.:.|....:|                       ::||....
Human   225 GGAPAKAEMKDMGIQVDRDLDGKSHKPLPLGVENDRVFNDLWGKGNVPVVLNNPYSEKEQPPTSG 289

  Fly   192 QDYRSRAGSFMHLDDEGRSLLMRKP------MRLKNIEGRPEVYDTLHCKGREILSCSKATCTSS 250
            :...::.||               |      :::||.|....:.||||.|......|::..|..|
Human   290 KQSPTKNGS---------------PSKCPRFLKVKNWETEVVLTDTLHLKSTLETGCTEYICMGS 339

  Fly   251 IMNIGNAA---VEARKSDLILEHAKDFLEQYFTSIKRTSSTAHETRWKQVRQSIETTGHYQLTET 312
            ||:....|   .:.|....:...||:|::||::||||..|.||..|.::|.:.|:||..|||.:|
Human   340 IMHPSQHARRPEDVRTKGQLFPLAKEFIDQYYSSIKRFGSKAHMERLEEVNKEIDTTSTYQLKDT 404

  Fly   313 ELIYGAKLAWRNSSRCIGRIQWSKLQVFDCRYVTTTSGMFEAICNHIKYATNKGNLRSAITIFPQ 377
            |||||||.||||:|||:||||||||||||.|..||..|||..||||:||||||||||||||||||
Human   405 ELIYGAKHAWRNASRCVGRIQWSKLQVFDARDCTTAHGMFNYICNHVKYATNKGNLRSAITIFPQ 469

  Fly   378 RTDAKHDYRIWNNQLISYAGYKQADGKIIGDPMNVEFTEVCTKLGWKSKGSEWDILPLVVSANGH 442
            |||.|||:|:||:|||.||||||.||..:|||.||:|||:|.:.|||.....:|:|||::.|||:
Human   470 RTDGKHDFRVWNSQLIRYAGYKQPDGSTLGDPANVQFTEICIQQGWKPPRGRFDVLPLLLQANGN 534

  Fly   443 DPDYFDYPPELILEVPLTHPKFEWFSDLGLRWYALPAVSSMLFDVGGIQFTATTFSGWYMSTEIG 507
            ||:.|..||||:||||:.|||||||.||||:||.|||||:||.::||::|:|..||||||.||||
Human   535 DPELFQIPPELVLEVPIRHPKFEWFKDLGLKWYGLPAVSNMLLEIGGLEFSACPFSGWYMGTEIG 599

  Fly   508 SRNLCDTNRRNMLETVALKMQLDTRTPTSLWKDKAVVEMNIAVLHSYQSRNVTIVDHHTASESFM 572
            .|:.||.:|.|:||.||.||.||.|..:|||||:|:||:|||||:|:||..|||||||:|:|||:
Human   600 VRDYCDNSRYNILEEVAKKMNLDMRKTSSLWKDQALVEINIAVLYSFQSDKVTIVDHHSATESFI 664

  Fly   573 KHFENESKLRNGCPADWIWIVPPLSGSITPVFHQEMALYYLKPSFEYQDPAWRTHVWKKGRGESK 637
            ||.|||.:.|.||||||:|||||:||||||||||||..|.|.||||||...|.|||||   |.:.
Human   665 KHMENEYRCRGGCPADWVWIVPPMSGSITPVFHQEMLNYRLTPSFEYQPDPWNTHVWK---GTNG 726

  Fly   638 GKKPRRKFNFKQIARAVKFTSKLFGRALSKRIKATVLYATETGKSEQYAKQLCELLGHAFNAQIY 702
            ....||...||::|.||||::||.|:|::||:|||:|||||||||:.|||.|||:..|||:|::.
Human   727 TPTKRRAIGFKKLAEAVKFSAKLMGQAMAKRVKATILYATETGKSQAYAKTLCEIFKHAFDAKVM 791

  Fly   703 CMSDYDISSIEHEALLIVVASTFGNGDPPENGELFSQELYAMR----VQESSE------------ 751
            .|.:|||..:|||.|::||.|||||||||||||.|...|..||    |||..:            
Human   792 SMEEYDIVHLEHETLVLVVTSTFGNGDPPENGEKFGCALMEMRHPNSVQEERKYPEPLRFFPRKG 856

  Fly   752 ----------HGL---QDSSIGSSK-SFMKASSRQEFMKLPLQQVKRIDRWDSLRGS-----TSD 797
                      |||   :||...|.| .|...||..                ||.:.|     ..|
Human   857 PPLPNGDTEVHGLAAARDSQHRSYKVRFNSVSSYS----------------DSQKSSGDGPDLRD 905

  Fly   798 TFTEETFGPLSNVRFAVFALGSSAYPNFCAFGQYVDNILGELGGERLLRVAYGDEMCGQEQSFRK 862
            .|  |:.|||:||||:||.|||.|||:|||||..||.:|.||||||:|::..|||:||||::||.
Human   906 NF--ESAGPLANVRFSVFGLGSRAYPHFCAFGHAVDTLLEELGGERILKMREGDELCGQEEAFRT 968

  Fly   863 WAPEVFKLACETFCLDPEESLSDASLAL-QND-SLTVNTVRLVPSANKGSLDSSLSKYHNKKVHC 925
            ||.:|||.||:.||:..:.::..|:.:| .|| |...|..||...|....|...||..|.|:|..
Human   969 WAKKVFKAACDVFCVGDDVNIEKANNSLISNDRSWKRNKFRLTFVAEAPELTQGLSNVHKKRVSA 1033

  Fly   926 CKAKAKPHNLTRLSEGAKTTMLLEICAPG---LEYEPGDHVGIFPANRTELVDGLLNRLVGVDNP 987
            .:..:: .|| :..:.:::|:.:.:...|   |:|:||||:|:||.|..:||:.|:.||......
Human  1034 ARLLSR-QNL-QSPKSSRSTIFVRLHTNGSQELQYQPGDHLGVFPGNHEDLVNALIERLEDAPPV 1096

  Fly   988 DEVLQLQLLKEKQTSNGIFKCWEPHDKIPPDTLRNLLARFFDLTTPPSRQLLTLLAGFCEDTADK 1052
            :::::::||:|:.|:.|:...|....::||.|:......:.|:||||:...|...|.......:|
Human  1097 NQMVKVELLEERNTALGVISNWTDELRLPPCTIFQAFKYYLDITTPPTPLQLQQFASLATSEKEK 1161

  Fly  1053 ERLELLVNDSSAYEDWRHWRLPHLLDVLEEFPSCRPPAPLLLAQLTPLQPRFYSISSSPRRVSDE 1117
            :||.:|......||:|:..:.|.:::|||||||.:.||.|||.||:.||||:|||||||....||
Human  1162 QRLLVLSKGLQEYEEWKWGKNPTIVEVLEEFPSIQMPATLLLTQLSLLQPRYYSISSSPDMYPDE 1226

  Fly  1118 IHLTVAIVKYRCEDGQGDERYGVCSNYLSGLRADDELFMFVRSALGFHLPSDRSRPIILIGPGTG 1182
            :|||||||.||..||:|...:||||::|:.::||:.:..|||.|..||||.:...|.||:|||||
Human  1227 VHLTVAIVSYRTRDGEGPIHHGVCSSWLNRIQADELVPCFVRGAPSFHLPRNPQVPCILVGPGTG 1291

  Fly  1183 IAPFRSFWQEFQVLSDLDPTAKLP-KMWLFFGCRNRDVD-LYAEEKAELQKDQILDRVFLALSRE 1245
            |||||||||:.|.  |:......| .|.|.||||...:| :|.||..:.:...:...::.|.|||
Human  1292 IAPFRSFWQQRQF--DIQHKGMNPCPMVLVFGCRQSKIDHIYREETLQAKNKGVFRELYTAYSRE 1354

  Fly  1246 QAIPKTYVQDLIEQEF-DSLYQLIVQERGHIYVCGDVTMAEHVYQTIRKCIAGKEQKSEAEVETF 1309
            ...||.||||:::::. :|:|:.:.::.||||||||||||..|.:.|::.:..:.:.|..:...|
Human  1355 PDKPKKYVQDILQEQLAESVYRALKEQGGHIYVCGDVTMAADVLKAIQRIMTQQGKLSAEDAGVF 1419

  Fly  1310 LLTLRDESRYHEDIFGITLRTAEIHTKSRATARIRMAS 1347
            :..:||::||||||||:||||.|:      |.|:|..|
Human  1420 ISRMRDDNRYHEDIFGVTLRTYEV------TNRLRSES 1451

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NosNP_523541.2 NOS_oxygenase_euk 216..624 CDD:238410 253/416 (61%)
CysJ 669..1323 CDD:223446 292/696 (42%)
Flavodoxin_1 673..863 CDD:278677 104/224 (46%)
Nitric_oxide_synthase 931..1328 CDD:99799 165/402 (41%)
NOS1NP_001191147.1 PDZ_signaling 15..98 CDD:238492
NOS_oxygenase_euk 305..716 CDD:238410 252/410 (61%)
CysJ 759..1433 CDD:223446 292/695 (42%)
Flavodoxin_1 762..969 CDD:278677 104/224 (46%)
Nitric_oxide_synthase 1035..1438 CDD:99799 165/406 (41%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 525 1.000 Domainoid score I292
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H37327
Inparanoid 1 1.050 1114 1.000 Inparanoid score I227
Isobase 1 0.950 - 0.75 Normalized mean entropy S1636
OMA 1 1.010 - - QHG46820
OrthoDB 1 1.010 - - D56017at33208
OrthoFinder 1 1.000 - - FOG0001418
OrthoInspector 1 1.000 - - otm42050
orthoMCL 1 0.900 - - OOG6_103176
Panther 1 1.100 - - O PTHR19384
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X3122
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
1312.930

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