DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nos and CG14882

DIOPT Version :9

Sequence 1:	NP_523541.2	Gene:	Nos / 34495	FlyBaseID:	FBgn0011676	Length:	1349	Species:	Drosophila melanogaster
Sequence 2:	NP_001262637.1	Gene:	CG14882 / 41994	FlyBaseID:	FBgn0038429	Length:	454	Species:	Drosophila melanogaster

Alignment Length:	409	Identity:	115/409 - (28%)
Similarity:	195/409 - (47%)	Gaps:	41/409 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   935 LTRLSEGAKTTMLLEICAPG-LEYEPGDHVGIFPANRTELVDGLLNRLVGVDNPDEVLQLQLLKE 998
            |....:..:|..::|:.... .:|:|||.:||.|||:.|.|:.||:||..:|..|....|:|
  Fly    67 LVSADKATETKRVVELTLESTFDYQPGDTIGILPANKLEQVESLLHRLELLDQADTTCHLKL--- 128

  Fly   999 KQTSNGIFKCWEPHDKIP-----PDTLRNLLARFFDLTTPPSRQLLTLLAGFCEDTADKERLEL- 1057
                  :|.|...:.|:|     ..|.|.:|.....|...|.:|||:.||||..|  ||||..|
  Fly   129 ------VFNCANKNAKLPAHIPATTTPREILTHCLSLNFVPQKQLLSALAGFTSD--DKERCFLS 185

  Fly  1058 LVNDSSAYEDWRHWRLPH---LLDVLEEFPSCRPPAPLLLAQLTPLQPRFYSISSSPRRVSD-EI 1118
            .::...|.|.::...|..   .:|:||...:||||...|...|..|.||.|||::||...|: |:
  Fly   186 CLSSKQATEYYQSLILEQGLLFIDILEVCVNCRPPLAFLAEHLPRLLPRPYSIANSPLEASNREL 250

  Fly  1119 HLTVAIVKYRCEDGQGDERYGVCSNYL------SGLRADDELFMFVR-SALGFHLPSDRSRPIIL 1176
            .:..:::..         :.||.::.|      |......::.::.| |.|..:...|..|..||
  Fly   251 RVIYSLLSL---------KPGVTTSMLEAAAQQSSPEHSKKVVIYPRMSNLFRYTERDVGRNQIL 306

  Fly  1177 IGPGTGIAPFRSFWQEFQVLSDLDPTAKLPKMWLFFGCRNRDVDLYAEEKAELQKDQILDRVFLA 1241
            |..|||:|||..|....:.|....|.....:.||:.|.:..:..|..|:..|.|:..:|:|:.:.
  Fly   307 IAVGTGLAPFLGFLAHKEELIKQQPQQPSGQSWLYIGAKTPEAVLKREKLMEWQESSLLERLRMC 371

  Fly  1242 LSREQAIPKTYVQDLIEQEFDSLYQLIVQERGHIYVCGD-VTMAEHVYQTIRKCIAGKEQKSEAE 1305
            .||.::  .:|||.::|::.:.|.:.:::....:|:|.| ..:::.:...:.:|:......:|.|
  Fly   372 YSRGES--PSYVQHMLEEDCEDLVEFLMKSETVLYICADGAKISQSIAGVLSRCLQKAMHLTEEE 434

  Fly  1306 VETFLLTLRDESRYHEDIF 1324
            ....|..||.:.:|.||::
  Fly   435 ASQLLKKLRKQDKYREDVW 453

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nos	NP_523541.2	NOS_oxygenase_euk	216..624	CDD:238410
		CysJ	669..1323	CDD:223446	114/406 (28%)
		Flavodoxin_1	673..863	CDD:278677
		Nitric_oxide_synthase	931..1328	CDD:99799	115/409 (28%)
CG14882	NP_001262637.1	methionine_synthase_red	66..453	CDD:99800	115/407 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45439819
Domainoid	1	1.000	52	1.000	Domainoid score	I664
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.840