DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nos and Ndor1

DIOPT Version :9

Sequence 1:	NP_523541.2	Gene:	Nos / 34495	FlyBaseID:	FBgn0011676	Length:	1349	Species:	Drosophila melanogaster
Sequence 2:	NP_001101288.1	Gene:	Ndor1 / 311799	RGDID:	1308479	Length:	598	Species:	Rattus norvegicus

Alignment Length:	706	Identity:	175/706 - (24%)
Similarity:	282/706 - (39%)	Gaps:	174/706 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   673 VLYATETGKSEQYAKQL-CELLGHAFNAQIYCMSDYDISSIEHEALLIVVASTFGNGDPPENGEL 736
            ||:.::||.::..|::| .|........::..:..|.::::..|.|:|.|.:|.|.||||:|
  Rat     8 VLFGSQTGTAQDEAERLGREARRRRLGCRVQALDSYSVANLIREPLVIFVCATTGQGDPPDN--- 69

  Fly   737 FSQELYAMRVQESSEHGLQDSSIGSSKSFMKASSRQEFMKLPLQQVKRIDRWDSLRGSTSDTFTE 801
                                     .|:|.:...|:   .||               |||
  Rat    70 -------------------------MKNFWRFIFRK---SLP---------------STS----- 86

  Fly   802 ETFGPLSNVRFAVFALGSSAYPNFCAFGQYVDNILGELGGERLLRVAYGDEM--CGQEQSFRKWA 864
                 |..:.|||..||.|:|..|....:.:...|.:|||..|:....||:.  .|.:.:...|.
  Rat    87 -----LCQMDFAVLGLGDSSYAKFNFVAKKLHRRLLQLGGNALVPPCLGDDQHELGPDAAIDPWV 146

  Fly   865 -----------------PE-----------VFKLACETFCLDPEESLSDASLALQNDSLTVNTVR 901
                             ||           :|:...|...:..||               :|...
  Rat   147 GDLWEKIMTMYPVPLDIPEIPHGVPLPSKFIFQFLQEVPSIGAEE---------------LNLAS 196

  Fly   902 LVPSANKGSLDSSLSK-YHNKKVHCCKAKAKPHNL--TRLSEGAKTTMLLEICAPGLEYEPGDHV 963
            ..|......|...|:. ..|::|      ..|.:.  .||.|       .:|....:.:..||.|
  Rat   197 SAPQTPPSELQPFLAPVVTNQRV------TGPQHFQDVRLME-------FDITESNISFAAGDVV 248

  Fly   964 GIFPANRTELVDGLLNRLVGVDNPDEVLQLQLLKEKQTSNGIFKCWEPHDKIPPD-----TLRNL 1023
            .|.|:| :|.......:|:.:| |::...|             |..||....||.     |:.:|
  Rat   249 LILPSN-SEAHTKQFCQLLCLD-PNQFFTL-------------KPREPGVPYPPGLPQHCTVWHL 298

  Fly  1024 LARFFDLTTPPSRQLLTLLAGFCEDTADKERLELLVNDSSAYEDWRHWRLPH--LLDVLEEFP-- 1084
            ::::.|:.:.|.|....|||.......::|:|....:.....|.|.:...|.  :|:||.:||
  Rat   299 VSQYLDIASVPRRSFFELLACLSPHALEREKLLEFSSARGQEELWEYCNRPRRTILEVLCDFPHT 363

  Fly  1085 -SCRPPAPLLLAQLTP-LQPRFYSISSS----PRRVSDEIHLTVAIVKYRCEDGQGDERYGVCSN 1143
             ...||..||  .|.| ::||.:||:||    |||    :.:.||:|||:..  ..:.|.|:||:
  Rat   364 AGAIPPDYLL--DLIPRIRPRAFSIASSLLAHPRR----LQILVAVVKYQTR--LKEPRRGLCSS 420

  Fly  1144 YLSGLRADD----ELFMFVR-SALGFHLPSDRSRPIILIGPGTGIAPFRSFWQEFQVLSDLDPTA 1203
            :|:.|....    .:.::|| .:|.|  |.....|||::|||||:||||:..||......:...
  Rat   421 WLASLTPGQAGPVRVPLWVRPGSLVF--PKTPGTPIIMVGPGTGVAPFRAAIQERVAHGQMGNV- 482

  Fly  1204 KLPKMWLFFGCRNRDVDLYAE-EKAELQKDQILDRVFLALSREQAIPKTYVQDLIEQEFDSLYQL 1267
                  ||||||.||.|.|.: |..||::...|..| .|.||||| .|.|||..:.:....:::|
  Rat   483 ------LFFGCRQRDQDFYWQTEWQELEQRGCLTLV-TAFSREQA-QKVYVQHRLRELGPLVWEL 539

  Fly  1268 IVQERGHIYVCGDVT-MAEHVYQTIRKCIAGKEQKSEAEVETFLLTLRDESRYHED 1322
            :..:..:.|:.|:.. |...|.:.:......:.:.|..:...:|..|:...|:..:
  Rat   540 LDGQGAYFYLAGNAKYMPTDVSEALTAIFQEEGRLSTTDAAAYLARLQQTLRFQTE 595

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nos	NP_523541.2	NOS_oxygenase_euk	216..624	CDD:238410
		CysJ	669..1323	CDD:223446	175/706 (25%)
		Flavodoxin_1	673..863	CDD:278677	44/192 (23%)
		Nitric_oxide_synthase	931..1328	CDD:99799	118/416 (28%)
Ndor1	NP_001101288.1	CysJ	6..597	CDD:223446	175/706 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910