Protein Alignment Nos and Mtrr

DIOPT Version :10

• Sequence 1: NP_523541.2
• Gene: Nos / 34495
• FlyBaseID: FBgn0011676
• Length: 1349
• Species: Drosophila melanogaster
• Sequence 2: NP_001425180.1
• Gene: Mtrr / 290947
• RGDID: 1308671
• Length: 700
• Species: Rattus norvegicus
• Alignment Length: 758
• Identity: 199/758 - (26%)
• Similarity: 324/758 - (42%)
• Gaps: 170/758 - (22%)

  Fly   673 VLYATETGKSEQYAKQLCE-LLGHAFNAQIYCMSD---YDISSIEHEALLIVVASTFGNGDPPEN 733
            :||||:.|:::..|:::.| .|.|.|:|.::|:|:   ||:.:  ....|::|.||.|.||||:.
  Rat     6 LLYATQRGQAKAIAEEISEQALSHGFSADLHCVSESEKYDLKT--ETGPLVMVVSTTGTGDPPDT 68

  Fly   734 GELFSQELYAMRVQESSEHGLQDSSIGSSKSFMKASSRQEFMKLPLQQVKRIDRWDSLRGSTSDT 798
            ...|.:|::                   :|:            ||                 :|.
  Rat    69 ARKFVKEIH-------------------NKT------------LP-----------------TDF 85

  Fly   799 FTEETFGPLSNVRFAVFALGSSAYPNFCAFGQYVDNILGELGGERLLRVAYGDEMCGQEQSFRKW 863
            |....:|        :..||.|.|..||..|:.:|..|.|||.:......:.|:..|.|.....|
  Rat    86 FAHLWYG--------LLGLGDSEYTYFCNGGKVIDKRLQELGAQHFYDTGHADDCVGLELVVEPW 142

  Fly   864 APEVFKLACETF-CLDPEESLSDA-----------SLALQNDSLTVNT-VRLVPSANKGSLDSSL 915
            ...::....:.| .|..:|.:||:           |:|::.:.|.:.: |.|:...:.|..||.|
  Rat   143 IDGLWPALTKHFKSLGGQEDMSDSDTLAQASDAPLSMAMKPELLHIQSQVELLSLEDVGKRDSEL 207

  Fly   916 SKYH--NK-----------------------------------KVHCCKAKAKPHNLTRL----- 938
            .:.:  ||                                   :|:..::..:..|...:
  Rat   208 QEQNETNKNQPSRIEDFDSSLVNSVPPLSQSSLSIPAVSPEYLEVYLQESLGQDENQASVPPSVD 272

  Fly   939 ---------------SEGAKTTMLLEICAPGLEY--EPGDHVGIFPANRTELVDGLLNRLVGVDN 986
                           ::..|||:|||:....:|:  :|||...:...|....|:.||.||...|.
  Rat   273 PIFQVPISKAVELTTNDAIKTTLLLELDISKVEFSHQPGDSFNVICPNSGSEVEDLLQRLQLADK 337

  Fly   987 PDE--VLQLQLLKEKQTSNGIFKCWEPHDKIPPDTLRNLLARFFDLTTPPSRQLLTLLAGFCEDT 1049
            ...  :|::::..:|:.::      .|.......:|:.:.....::...|.:..|..|:.:..|.
  Rat   338 QAHRVILKIKMDTKKKGAS------LPQHVPEGSSLQFIFTWCLEIRAVPKKAFLRALSDYTSDA 396

  Fly  1050 ADKERLELLVNDSSAYEDWRHWRLPH--LLDVLEEFPSCRPPAPLLLAQLTPLQPRFYSISSSPR 1112
            .:|.||:.|.:...|.:..|..|...  |||:|..||||:||..|||..|..||||.||.:||..
  Rat   397 TEKRRLQELCSKQGAADYNRFIRDASVCLLDLLLTFPSCQPPLNLLLEHLPKLQPRPYSCASSSL 461

  Fly  1113 RVSDEIHLTVAIVKYRCEDGQGDERYGVCSNYLSGLRAD------------------DELFMFVR 1159
            ...|::|....||:..........|.|||:.:|:.|.|.                  .|:.:..|
  Rat   462 LHPDKLHFVFNIVELPSNTTAASLRKGVCTGWLATLVAPFLQPNTEVLTADHSDALAPEILISPR 526

  Fly  1160 SALGFHLPSDRSRPIILIGPGTGIAPFRSFWQEFQVLSDLDPTAKLPKMWLFFGCRNRDVD-LYA 1223
            :...||||.|.|.|||::|||||:|||..|.|..:.|.:..|......||||||||::|.| |:.
  Rat   527 ATNSFHLPDDLSAPIIMVGPGTGVAPFVGFLQHREKLQEQHPDGNFGAMWLFFGCRHKDRDYLFR 591

  Fly  1224 EEKAELQKDQILDRVFLALSR------EQAIPKTYVQDLIEQEFDSLYQLIVQERGHIYVCGDV- 1281
            ||.....|..:|..:.::.||      |:..|..||||.::.....:.:.::||.|:||||||.
  Rat   592 EELRHFLKTGVLTHLKVSFSRDAAPEEEEEAPAKYVQDNLQHHSQQVARTLLQENGYIYVCGDAK 656

  Fly  1282 TMAEHVYQTIRKCIAGKEQKSEAEVETFLLTLRDESRYHEDIF 1324
            .||:.|:..:.:.|:.:....:.|....|.||:.|.||.:||:
  Rat   657 NMAKDVHDALVEIISKEAGVDKLEAMKTLATLKQEKRYLQDIW 699

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nos	NP_523541.2	NOS_oxygenase_euk	216..624	CDD:238410
		Flavodoxin_1	673..863	CDD:425562	47/193 (24%)
		Nitric_oxide_synthase	931..1328	CDD:99799	134/446 (30%)
Mtrr	NP_001425180.1	Hinge. /evidence=ECO:0000250	168..247		11/78 (14%)