DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nos and Mtrr

DIOPT Version :9

Sequence 1:	NP_523541.2	Gene:	Nos / 34495	FlyBaseID:	FBgn0011676	Length:	1349	Species:	Drosophila melanogaster
Sequence 2:	XP_006227875.1	Gene:	Mtrr / 290947	RGDID:	1308671	Length:	700	Species:	Rattus norvegicus

Alignment Length:	758	Identity:	199/758 - (26%)
Similarity:	324/758 - (42%)	Gaps:	170/758 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   673 VLYATETGKSEQYAKQLCE-LLGHAFNAQIYCMSD---YDISSIEHEALLIVVASTFGNGDPPEN 733
            :||||:.|:::..|:::.| .|.|.|:|.::|:|:   ||:.:  ....|::|.||.|.||||:.
  Rat     6 LLYATQRGQAKAIAEEISEQALSHGFSADLHCVSESEKYDLKT--ETGPLVMVVSTTGTGDPPDT 68

  Fly   734 GELFSQELYAMRVQESSEHGLQDSSIGSSKSFMKASSRQEFMKLPLQQVKRIDRWDSLRGSTSDT 798
            ...|.:|::                   :|:            ||                 :|.
  Rat    69 ARKFVKEIH-------------------NKT------------LP-----------------TDF 85

  Fly   799 FTEETFGPLSNVRFAVFALGSSAYPNFCAFGQYVDNILGELGGERLLRVAYGDEMCGQEQSFRKW 863
            |....:|        :..||.|.|..||..|:.:|..|.|||.:......:.|:..|.|.....|
  Rat    86 FAHLWYG--------LLGLGDSEYTYFCNGGKVIDKRLQELGAQHFYDTGHADDCVGLELVVEPW 142

  Fly   864 APEVFKLACETF-CLDPEESLSDA-----------SLALQNDSLTVNT-VRLVPSANKGSLDSSL 915
            ...::....:.| .|..:|.:||:           |:|::.:.|.:.: |.|:...:.|..||.|
  Rat   143 IDGLWPALTKHFKSLGGQEDMSDSDTLAQASDAPLSMAMKPELLHIQSQVELLSLEDVGKRDSEL 207

  Fly   916 SKYH--NK-----------------------------------KVHCCKAKAKPHNLTRL----- 938
            .:.:  ||                                   :|:..::..:..|...:
  Rat   208 QEQNETNKNQPSRIEDFDSSLVNSVPPLSQSSLSIPAVSPEYLEVYLQESLGQDENQASVPPSVD 272

  Fly   939 ---------------SEGAKTTMLLEICAPGLEY--EPGDHVGIFPANRTELVDGLLNRLVGVDN 986
                           ::..|||:|||:....:|:  :|||...:...|....|:.||.||...|.
  Rat   273 PIFQVPISKAVELTTNDAIKTTLLLELDISKVEFSHQPGDSFNVICPNSGSEVEDLLQRLQLADK 337

  Fly   987 PDE--VLQLQLLKEKQTSNGIFKCWEPHDKIPPDTLRNLLARFFDLTTPPSRQLLTLLAGFCEDT 1049
            ...  :|::::..:|:.::      .|.......:|:.:.....::...|.:..|..|:.:..|.
  Rat   338 QAHRVILKIKMDTKKKGAS------LPQHVPEGSSLQFIFTWCLEIRAVPKKAFLRALSDYTSDA 396

  Fly  1050 ADKERLELLVNDSSAYEDWRHWRLPH--LLDVLEEFPSCRPPAPLLLAQLTPLQPRFYSISSSPR 1112
            .:|.||:.|.:...|.:..|..|...  |||:|..||||:||..|||..|..||||.||.:||..
  Rat   397 TEKRRLQELCSKQGAADYNRFIRDASVCLLDLLLTFPSCQPPLNLLLEHLPKLQPRPYSCASSSL 461

  Fly  1113 RVSDEIHLTVAIVKYRCEDGQGDERYGVCSNYLSGLRAD------------------DELFMFVR 1159
            ...|::|....||:..........|.|||:.:|:.|.|.                  .|:.:..|
  Rat   462 LHPDKLHFVFNIVELPSNTTAASLRKGVCTGWLATLVAPFLQPNTEVLTADHSDALAPEILISPR 526

  Fly  1160 SALGFHLPSDRSRPIILIGPGTGIAPFRSFWQEFQVLSDLDPTAKLPKMWLFFGCRNRDVD-LYA 1223
            :...||||.|.|.|||::|||||:|||..|.|..:.|.:..|......||||||||::|.| |:.
  Rat   527 ATNSFHLPDDLSAPIIMVGPGTGVAPFVGFLQHREKLQEQHPDGNFGAMWLFFGCRHKDRDYLFR 591

  Fly  1224 EEKAELQKDQILDRVFLALSR------EQAIPKTYVQDLIEQEFDSLYQLIVQERGHIYVCGDV- 1281
            ||.....|..:|..:.::.||      |:..|..||||.::.....:.:.::||.|:||||||.
  Rat   592 EELRHFLKTGVLTHLKVSFSRDAAPEEEEEAPAKYVQDNLQHHSQQVARTLLQENGYIYVCGDAK 656

  Fly  1282 TMAEHVYQTIRKCIAGKEQKSEAEVETFLLTLRDESRYHEDIF 1324
            .||:.|:..:.:.|:.:....:.|....|.||:.|.||.:||:
  Rat   657 NMAKDVHDALVEIISKEAGVDKLEAMKTLATLKQEKRYLQDIW 699

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nos	NP_523541.2	NOS_oxygenase_euk	216..624	CDD:238410
		CysJ	669..1323	CDD:223446	197/755 (26%)
		Flavodoxin_1	673..863	CDD:278677	47/193 (24%)
		Nitric_oxide_synthase	931..1328	CDD:99799	134/446 (30%)
Mtrr	XP_006227875.1	Flavodoxin_1	6..142	CDD:395199	47/193 (24%)
Mtrr	XP_006227875.1	methionine_synthase_red	278..699	CDD:99800	132/426 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910