DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nos and NDOR1

DIOPT Version :9

Sequence 1:	NP_523541.2	Gene:	Nos / 34495	FlyBaseID:	FBgn0011676	Length:	1349	Species:	Drosophila melanogaster
Sequence 2:	NP_001137498.1	Gene:	NDOR1 / 27158	HGNCID:	29838	Length:	606	Species:	Homo sapiens

Alignment Length:	696	Identity:	175/696 - (25%)
Similarity:	298/696 - (42%)	Gaps:	146/696 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   673 VLYATETGKSEQYAKQL-CELLGHAFNAQIYCMSDYDISSIEHEALLIVVASTFGNGDPPENGEL 736
            ||:.::||.::..:::| .|........::..:..|.:.::.:|.|:|.|.:|.|.||||:|
Human     8 VLFGSQTGTAQDVSERLGREARRRRLGCRVQALDSYPVVNLINEPLVIFVCATTGQGDPPDN--- 69

  Fly   737 FSQELYAMRVQESSEHGLQDSSIGSSKSFMKASSRQEFMKLPLQQVKRIDRWDSLRGSTSDTFTE 801
                                     .|:|.:...|:   .||               ||:
Human    70 -------------------------MKNFWRFIFRK---NLP---------------STA----- 86

  Fly   802 ETFGPLSNVRFAVFALGSSAYPNFCAFGQYVDNILGELGGERLLRVAYGDEM--CGQEQSFRKWA 864
                 |..:.|||..||.|:|..|....:.:...|.:|||..||.|..||:.  .|.:.:...|.
Human    87 -----LCQMDFAVLGLGDSSYAKFNFVAKKLHRRLLQLGGSALLPVCLGDDQHELGPDAAVDPWL 146

  Fly   865 PEVFKLACETFCLDPEESLSD-----------ASLALQNDSLTVNTVRLV--------PSANKGS 910
            .:::......:  .|...|::           ..|.||....|.:..:.|        ||.:|..
Human   147 RDLWDRVLGLY--PPPPGLTEIPPGVPLPSKFTLLFLQEAPSTGSEGQRVAHPGSQEPPSESKPF 209

  Fly   911 LDSSLSKYHNKKVHCCKAKAKPHNL--TRLSEGAKTTMLLEICAPGLEYEPGDHVGIFPANRTEL 973
            |...:|   |::|      ..|.:.  .||.|       .:|...|:.:..||.|.|.|:|....
Human   210 LAPMIS---NQRV------TGPSHFQDVRLIE-------FDILGSGISFAAGDVVLIQPSNSAAH 258

  Fly   974 VDGLLNRLVGVDNPDEVLQLQLLKEKQTSNGIFKCWEPHDKIP-PDTLRNLLARFFDLTTPPSRQ 1037
            |.... :::|:| ||::..|| .:|...|:        ..::| |.::|:|::.:.|:.:.|.|.
Human   259 VQRFC-QVLGLD-PDQLFMLQ-PREPDVSS--------PTRLPQPCSMRHLVSHYLDIASVPRRS 312

  Fly  1038 LLTLLAGFCEDTADKERLELLVNDSSAY---EDWRHWRLPH--LLDVLEEFP--SCRPPAPLLLA 1095
            ...|||  |....:.|| |.|:..|||.   |.:.:...|.  :|:||.:||  :...|...||.
Human   313 FFELLA--CLSLHELER-EKLLEFSSAQGQEELFEYCNRPRRTILEVLCDFPHTAAAIPPDYLLD 374

  Fly  1096 QLTPLQPRFYSISSSPRRVSDEIHLTVAIVKYRCEDGQGDERYGVCSNYLSGL---RADDELFMF 1157
            .:..::||.:||:||.......:.:.||:|:::..  ..:.|.|:||::|:.|   :....:.::
Human   375 LIPVIRPRAFSIASSLLTHPSRLQILVAVVQFQTR--LKEPRRGLCSSWLASLDPGQGPVRVPLW 437

  Fly  1158 VR-SALGFHLPSDRSRPIILIGPGTGIAPFRSFWQEFQVLSDLDPTAKLPKMWLFFGCRNRDVDL 1221
            || .:|.|  |.....|:|::|||||:||||:..||........       .:||||||.||.|.
Human   438 VRPGSLAF--PETPDTPVIMVGPGTGVAPFRAAIQERVAQGQTG-------NFLFFGCRWRDQDF 493

  Fly  1222 YAE-EKAELQKDQILDRVFLALSREQ------AI--PKTYVQDLIEQEFDSLYQLIVQERGHIYV 1277
            |.| |..||:|...| .:..|.||||      |:  .|.|||..:.:....:::|:.::..:.|:
Human   494 YWEAEWQELEKRDCL-TLIPAFSREQPPALFSALQEQKVYVQHRLRELGSLVWELLDRQGAYFYL 557

  Fly  1278 CGDV-TMAEHVYQTIRKCIAGKEQKSEAEVETFLLTLRDESRYHED 1322
            .|:. :|...|.:.:......:......:...:|..|:...|:..:
Human   558 AGNAKSMPADVSEALMSIFQEEGGLCSPDAAAYLARLQQTRRFQTE 603

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nos	NP_523541.2	NOS_oxygenase_euk	216..624	CDD:238410
		CysJ	669..1323	CDD:223446	175/696 (25%)
		Flavodoxin_1	673..863	CDD:278677	44/192 (23%)
		Nitric_oxide_synthase	931..1328	CDD:99799	116/416 (28%)
NDOR1	NP_001137498.1	CysJ	3..605	CDD:223446	175/696 (25%)
		Flavodoxin_1	8..145	CDD:278677	44/192 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	188..207		3/18 (17%)
		FNR_like	212..605	CDD:297884	119/434 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910