DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Nos and Nos3

DIOPT Version :9

Sequence 1:NP_523541.2 Gene:Nos / 34495 FlyBaseID:FBgn0011676 Length:1349 Species:Drosophila melanogaster
Sequence 2:NP_068610.1 Gene:Nos3 / 24600 RGDID:3186 Length:1202 Species:Rattus norvegicus


Alignment Length:1231 Identity:557/1231 - (45%)
Similarity:752/1231 - (61%) Gaps:105/1231 - (8%)


- Green bases have known domain annotations that are detailed below.


  Fly   152 GVGVGQGAGCPPSGSCTASGKSSRELSPSPKNQQ-----QPRKMSQDYRSRAGSFMHLDDEGRSL 211
            |:|:|.|.|.     |...|.:    ||:|:..|     .|.:.:.|:...              
  Rat    16 GLGLGLGLGL-----CGKQGPA----SPAPEPSQAPVPPSPTRPAPDHSPP-------------- 57

  Fly   212 LMRKP-----MRLKNIEGRPEVYDTLHCKGREILSCSKATCTSSIMNIGNAAVEARK-------- 263
            |.|.|     .|:||.|.....||||..:.::...|:...|..|:       |..||        
  Rat    58 LTRPPDGPKFPRVKNWEVGSITYDTLSAQAQQDGPCTPRRCLGSL-------VFPRKLQSRPTQG 115

  Fly   264 ---SDLILEHAKDFLEQYFTSIKRTSSTAHETRWKQVRQSIETTGHYQLTETELIYGAKLAWRNS 325
               ::.:|..|:||:.||:.||||:.|.|||.|.::|...:..||.|||.|:||::|||.||||:
  Rat   116 PSPTEQLLGQARDFINQYYNSIKRSGSQAHEQRLQEVEAEVVATGTYQLRESELVFGAKQAWRNA 180

  Fly   326 SRCIGRIQWSKLQVFDCRYVTTTSGMFEAICNHIKYATNKGNLRSAITIFPQRTDAKHDYRIWNN 390
            .||:|||||.||||||.|...|...||..||||||||||:||||||||:||||...:.|:||||:
  Rat   181 PRCVGRIQWGKLQVFDARDCRTAQEMFTYICNHIKYATNRGNLRSAITVFPQRYAGRGDFRIWNS 245

  Fly   391 QLISYAGYKQADGKIIGDPMNVEFTEVCTKLGWKSKGSEWDILPLVVSANGHDPDYFDYPPELIL 455
            ||:.||||:|.||.:.|||.|||.||:|.:.||......:|:|||::.|....|:.|..||||:|
  Rat   246 QLVRYAGYRQQDGSVRGDPANVEITELCIQHGWTPGNGRFDVLPLLLQAPDEPPELFTLPPELVL 310

  Fly   456 EVPLTHPKFEWFSDLGLRWYALPAVSSMLFDVGGIQFTATTFSGWYMSTEIGSRNLCDTNRRNML 520
            ||||.||..|||:.||||||||||||:||.::||::|.|..|||||||:|||.|:|||.:|.|:|
  Rat   311 EVPLEHPTLEWFAALGLRWYALPAVSNMLLEIGGLEFPAAPFSGWYMSSEIGMRDLCDPHRYNIL 375

  Fly   521 ETVALKMQLDTRTPTSLWKDKAVVEMNIAVLHSYQSRNVTIVDHHTASESFMKHFENESKLRNGC 585
            |.||:.|.|||||.:|||||||.||:|:|||:|||...|||||||.|:.|||||.|||.|.|.||
  Rat   376 EDVAVCMDLDTRTTSSLWKDKAAVEINVAVLYSYQLAKVTIVDHHAATASFMKHLENEQKARGGC 440

  Fly   586 PADWIWIVPPLSGSITPVFHQEMALYYLKPSFEYQDPAWRTHVWKKGRGESKGKKPRRKFNFKQI 650
            ||||.|||||:|||:||||||||..|:|.|:|.||...|      || ..:||....||..||::
  Rat   441 PADWAWIVPPISGSLTPVFHQEMVNYFLSPAFRYQPDPW------KG-SAAKGTGITRKKTFKEV 498

  Fly   651 ARAVKFTSKLFGRALSKRIKATVLYATETGKSEQYAKQLCELLGHAFNAQIYCMSDYDISSIEHE 715
            |.|||.::.|.|..::||:|||:||.:|||:::.||:||..|...||:.::.||.:||:.|:|||
  Rat   499 ANAVKISASLMGTVMAKRVKATILYGSETGRAQSYAQQLGRLFRKAFDPRVLCMDEYDVVSLEHE 563

  Fly   716 ALLIVVASTFGNGDPPENGELFSQELYAM--------RVQESSEHGLQDSSIGSSKSFMKASSRQ 772
            ||::||.|||||||||||||.|:..|..|        |.::...:.::.:|:..|.         
  Rat   564 ALVLVVTSTFGNGDPPENGESFAAALMEMSGPYNSSPRPEQHKSYKIRFNSVSCSD--------- 619

  Fly   773 EFMKLPLQQVKRIDRWDSLRGSTSDTFTEETFGPLSNVRFAVFALGSSAYPNFCAFGQYVDNILG 837
                 ||     :..|...|..:|:|   ::.|.|..:||.||.|||.|||:||||.:.||..|.
  Rat   620 -----PL-----VSSWRRKRKESSNT---DSAGALGTLRFCVFGLGSRAYPHFCAFARAVDTRLE 671

  Fly   838 ELGGERLLRVAYGDEMCGQEQSFRKWAPEVFKLACETFCLDPEESLSDASLALQNDSLTVNTVRL 902
            ||||||||::..|||:||||::||.||...|:.||||||:..:...:...:.....|......||
  Rat   672 ELGGERLLQLGQGDELCGQEEAFRGWAQAAFQAACETFCVGEDAKAAARDIFSPKRSWKRQRYRL 736

  Fly   903 VPSANKGSLDSSLSKYHNKKVHCCKAKAKPHNLTRLSEGAKTTMLLEI---CAPGLEYEPGDHVG 964
            ...|....|...|:..|.:|:.  :|........:.|:..:.|:|:.:   ...||:|:||||:|
  Rat   737 STQAESLQLLPGLTHVHRRKMF--QATILSVENLQSSKSTRATILVRLDTGSQEGLQYQPGDHIG 799

  Fly   965 IFPANRTELVDGLLNRLVGVDNPDEVLQLQLLKEKQTSNGIFKCWEPHDKIPPDTLRNLLARFFD 1029
            :.|.||..||:.||:|:.......|.:.::.| ||.:..|....|....::||.|||..|..|.|
  Rat   800 VCPPNRPGLVEALLSRVEDPPPSTEPVAVEQL-EKGSPGGPPPGWVRDPRLPPCTLRQALTYFLD 863

  Fly  1030 LTTPPSRQLLTLLAGFCEDTADKERLELLVNDSSAYEDWRHWRLPHLLDVLEEFPSCRPPAPLLL 1094
            :|:|||.:||.||:...|::::::.||.|..|...||:|:.:|.|.||:|||:|||...||||:|
  Rat   864 ITSPPSPRLLRLLSTLAEESSEQQELEALSQDPRRYEEWKWFRCPTLLEVLEQFPSVALPAPLIL 928

  Fly  1095 AQLTPLQPRFYSISSSPRRVSDEIHLTVAIVKYRCEDGQGDERYGVCSNYLSGLRADDELFMFVR 1159
            .||..||||:||:||:|.....|||||||::.||.:|..|...|||||.::|.|:|.|.:..|:|
  Rat   929 TQLPLLQPRYYSVSSAPSAHPGEIHLTVAVLAYRTQDVLGPLHYGVCSTWMSQLKAGDPVPCFIR 993

  Fly  1160 SALGFHLPSDRSRPIILIGPGTGIAPFRSFWQEFQVLSDLDPTAKLP-KMWLFFGCRNRDVD-LY 1222
            .|..|.||.|.:.|.||:||||||||||.|||:  .|.|::.....| .|.|.||||...:| ||
  Rat   994 GAPSFRLPPDPNLPCILVGPGTGIAPFRGFWQD--RLHDIEIKGLQPAPMTLVFGCRCSQLDHLY 1056

  Fly  1223 AEEKAELQKDQILDRVFLALSREQAIPKTYVQDLIEQEFDS-LYQLIVQERGHIYVCGDVTMAEH 1286
            .:|..:.|:..:..:|..|.||:...||||||||:..|..: :::::..|:||::||||||||..
  Rat  1057 RDEVLDAQQRGVFGQVLTAFSRDPGSPKTYVQDLLRTELAAEVHRVLCLEQGHMFVCGDVTMATS 1121

  Fly  1287 VYQTIRKCIAGKEQKSEAEVETFLLTLRDESRYHEDIFGITLRTAEIHTKSRATARIRMAS 1347
            |.||:::.:|.:......|....:..|||:.||||||||:||||.|:      |:|||..|
  Rat  1122 VLQTVQRILATEGSMELDEAGDVIGVLRDQQRYHEDIFGLTLRTQEV------TSRIRTQS 1176

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NosNP_523541.2 NOS_oxygenase_euk 216..624 CDD:238410 237/423 (56%)
CysJ 669..1323 CDD:223446 274/667 (41%)
Flavodoxin_1 673..863 CDD:278677 85/197 (43%)
Nitric_oxide_synthase 931..1328 CDD:99799 172/402 (43%)
Nos3NP_068610.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..70 16/76 (21%)
FLO_LFY 30..>61 CDD:279962 8/48 (17%)
NOS_oxygenase_euk 67..479 CDD:238410 236/418 (56%)
Interaction with NOSIP. /evidence=ECO:0000250 97..485 230/401 (57%)
Calmodulin-binding. /evidence=ECO:0000255 489..509 8/19 (42%)
CysJ 511..1158 CDD:223446 276/673 (41%)
Flavodoxin_1 521..697 CDD:278677 85/197 (43%)
FNR_like 761..1163 CDD:297884 172/404 (43%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 817..843 5/26 (19%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 526 1.000 Domainoid score I283
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 1111 1.000 Inparanoid score I213
OMA 1 1.010 - - QHG46820
OrthoDB 1 1.010 - - D56017at33208
OrthoFinder 1 1.000 - - FOG0001418
OrthoInspector 1 1.000 - - otm46194
orthoMCL 1 0.900 - - OOG6_103176
Panther 1 1.100 - - LDO PTHR19384
Phylome 1 0.910 - -
SonicParanoid 1 1.000 - - X3122
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
1110.980

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