DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Nos and Nos2

DIOPT Version :9

Sequence 1:NP_523541.2 Gene:Nos / 34495 FlyBaseID:FBgn0011676 Length:1349 Species:Drosophila melanogaster
Sequence 2:NP_036743.3 Gene:Nos2 / 24599 RGDID:3185 Length:1147 Species:Rattus norvegicus


Alignment Length:1179 Identity:530/1179 - (44%)
Similarity:708/1179 - (60%) Gaps:120/1179 - (10%)


- Green bases have known domain annotations that are detailed below.


  Fly   179 PSPKNQQQPRKMSQDYRSRAGSF--------------MHLDDEGRSLLMRKPMRLKNIEGRPEVY 229
            |||..|..|:  |..:::....|              :|:....|.    :.:|:|| .|..|::
  Rat    36 PSPTTQDDPK--SHKHQNGFPQFLTGTAQNVPESLDKLHVTPSTRP----QHVRIKN-WGNGEIF 93

  Fly   230 -DTLHCKGREILSCSKATCTSSIMNIGNAAVEARKS----DLILEHAKDFLEQYFTSIKRTSSTA 289
             ||||.|....:||....|..||||..:.....|..    :.:|..|.:|:.||:.|.|......
  Rat    94 HDTLHHKATSDISCKSKLCMGSIMNSKSLTRGPRDKPTPVEELLPQAIEFINQYYGSFKEAKIEE 158

  Fly   290 HETRWKQVRQSIETTGHYQLTETELIYGAKLAWRNSSRCIGRIQWSKLQVFDCRYVTTTSGMFEA 354
            |..|.:.|.:.|||||.||||..|||:..|:||||:.|||||||||.|||||.|..:|.|.||:.
  Rat   159 HLARLEAVTKEIETTGTYQLTLDELIFATKMAWRNAPRCIGRIQWSNLQVFDARSCSTASEMFQH 223

  Fly   355 ICNHIKYATNKGNLRSAITIFPQRTDAKHDYRIWNNQLISYAGYKQADGKIIGDPMNVEFTEVCT 419
            ||.||.||||.||:|||||:||||:|.|||:||||:|||.||||:..||.|.|||..:|||::|.
  Rat   224 ICRHILYATNSGNIRSAITVFPQRSDGKHDFRIWNSQLIRYAGYQMPDGTIRGDPATLEFTQLCI 288

  Fly   420 KLGWKSKGSEWDILPLVVSANGHDPDYFDYPPELILEVPLTHPKFEWFSDLGLRWYALPAVSSML 484
            .||||.:...:|:||||:.|:|.||:.|:.||:|:|||.:.|||:|||.:|||:|||||||::||
  Rat   289 DLGWKPRYGRFDVLPLVLQAHGQDPEVFEIPPDLVLEVTMEHPKYEWFQELGLKWYALPAVANML 353

  Fly   485 FDVGGIQFTATTFSGWYMSTEIGSRNLCDTNRRNMLETVALKMQLDTRTPTSLWKDKAVVEMNIA 549
            .:|||::|.|..|:||||.||||.|:.|||.|.|:||.|...|.|:|.|..|||||:||.|:|.|
  Rat   354 LEVGGLEFPACPFNGWYMGTEIGVRDFCDTQRYNILEEVGRSMGLETHTLASLWKDRAVTEINAA 418

  Fly   550 VLHSYQSRNVTIVDHHTASESFMKHFENESKLRNGCPADWIWIVPPLSGSITPVFHQEMALYYLK 614
            ||||:|.:||||:||||||||||||.:||.:.|.||||||||:|||:||||||||||||..|.|.
  Rat   419 VLHSFQKQNVTIMDHHTASESFMKHMQNEYRARGGCPADWIWLVPPVSGSITPVFHQEMLNYVLS 483

  Fly   615 PSFEYQDPAWRTHVWKKGRGESKGKKPRRKFNFKQIARAVKFTSKLFGRALSKRIKATVLYATET 679
            |.:.||...|:||:|:    :.|.:..||:..|..:.:||.|.|.|..:.::.|::||||:||||
  Rat   484 PFYYYQIEPWKTHIWQ----DEKLRPRRREIRFTVLVKAVFFASVLMRKVMASRVRATVLFATET 544

  Fly   680 GKSEQYAKQLCELLGHAFNAQIYCMSDYDISSIEHEALLIVVASTFGNGDPPENGELFSQELYAM 744
            ||||..|:.|..|..:|||.::.||..|..:::|.|.||:||.|||||||.|.||:...:.|:.|
  Rat   545 GKSEALARDLAALFSYAFNTKVVCMEQYKANTLEEEQLLLVVTSTFGNGDCPSNGQTLKKSLFMM 609

  Fly   745 RVQESSEHGLQDSSIGSSKSFMKASSRQEFMKLPLQQVKRIDRWDSLRGSTSDTFTEETFGPLSN 809
            :            .:|                                         .||     
  Rat   610 K------------ELG-----------------------------------------HTF----- 616

  Fly   810 VRFAVFALGSSAYPNFCAFGQYVDNILGELGGERLLRVAYGDEMCGQEQSFRKWAPEVFKLACET 874
             |:|||.||||.||.||||...:|..|..||..:|.....|||:.|||.:||.||.:.|:.||||
  Rat   617 -RYAVFGLGSSMYPQFCAFAHDIDQKLSHLGASQLAPTGEGDELSGQEDAFRSWAVQTFRAACET 680

  Fly   875 F------CLD-PEESLSDASLALQNDSLTVNTVRLVPSANKGSLDSSLSKYHNKKVHCCKAKAKP 932
            |      |:. |:...|:|:...:...||.:...|       .|:.:||..|.|.|...:.|:. 
  Rat   681 FDVRSKHCIQIPKRYTSNATWEPEQYKLTQSPESL-------DLNKALSSIHAKNVFTMRLKSL- 737

  Fly   933 HNLTRLSEGAKTTMLLEIC---APGLEYEPGDHVGIFPANRTELVDGLLNRLVGVDNPDEVLQLQ 994
            .|| :..:.::||:|:::.   :.|..|.||:|:||||.|:|.||.|:|.|:|...:||:.:.|:
  Rat   738 QNL-QSEKSSRTTLLVQLTFEGSRGPSYLPGEHLGIFPGNQTALVQGILERVVDCSSPDQTVCLE 801

  Fly   995 LLKEKQTSNGIFKCWEPHDKIPPDTLRNLLARFFDLTTPPSRQLLTLLAGFCEDTADKERLELLV 1059
            :|.|    :|.:  |....::||.:||..|..|.|:||||::..|..||.|..:...::|||.|.
  Rat   802 VLDE----SGSY--WVKDKRLPPCSLRQALTYFLDITTPPTQLQLHKLARFATEETHRQRLEALC 860

  Fly  1060 NDSSAYEDWRHWRLPHLLDVLEEFPSCRPPAPLLLAQLTPLQPRFYSISSSPRRVSDEIHLTVAI 1124
            ..|. |.||:....|..|:|||||||.|.||..||.||..|:||:||||||......|:|||||:
  Rat   861 QPSE-YNDWKFSNNPTFLEVLEEFPSLRVPAAFLLLQLPILKPRYYSISSSQDHTPSEVHLTVAV 924

  Fly  1125 VKYRCEDGQGDERYGVCSNYLSGLRADDELFMFVRSALGFHLPSDRSRPIILIGPGTGIAPFRSF 1189
            |.||..||||...:||||.:::.|:.:|.:..||||..||.||.|.|:|.|||||||||||||||
  Rat   925 VTYRTRDGQGPLHHGVCSTWINNLKPEDPVPCFVRSVSGFQLPEDPSQPCILIGPGTGIAPFRSF 989

  Fly  1190 WQEFQVLSDLDPTA-KLPKMWLFFGCRNRDVD-LYAEEKAELQKDQILDRVFLALSREQAIPKTY 1252
            ||  |.|.|..... |..:|.|.||||:.:.| ||.||..|:.:..:|.:|....||....||.|
  Rat   990 WQ--QRLHDSQHRGLKGGRMTLVFGCRHPEEDHLYQEEMQEMVRKGVLFQVHTGYSRLPGKPKVY 1052

  Fly  1253 VQDLIEQEF-DSLYQLIVQERGHIYVCGDVTMAEHVYQTIRKCIAGKEQKSEAEVETFLLTLRDE 1316
            |||::::|. |.::.::..|:||:||||||.||..|..|::|.:|.|...||.:||.:...|:.:
  Rat  1053 VQDILQKELADEVFSVLHGEQGHLYVCGDVRMARDVATTLKKLVAAKLNLSEEQVEDYFFQLKSQ 1117

  Fly  1317 SRYHEDIFG 1325
            .||||||||
  Rat  1118 KRYHEDIFG 1126

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NosNP_523541.2 NOS_oxygenase_euk 216..624 CDD:238410 235/412 (57%)
CysJ 669..1323 CDD:223446 268/666 (40%)
Flavodoxin_1 673..863 CDD:278677 67/189 (35%)
Nitric_oxide_synthase 931..1328 CDD:99799 181/401 (45%)
Nos2NP_036743.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 22..51 6/16 (38%)
DINNN-motif, mediates interaction with SPSB1, SPSB2 and SPSB4. /evidence=ECO:0000250|UniProtKB:P35228 23..27
NOS_oxygenase_euk 81..493 CDD:238410 235/412 (57%)
Calmodulin-binding. /evidence=ECO:0000255 506..526 7/19 (37%)
CysJ 537..1124 CDD:223446 267/663 (40%)
Flavodoxin_1 538..669 CDD:278677 67/189 (35%)
FNR_like 733..1129 CDD:297884 182/405 (45%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 526 1.000 Domainoid score I283
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 1111 1.000 Inparanoid score I213
OMA 1 1.010 - - QHG46820
OrthoDB 1 1.010 - - D56017at33208
OrthoFinder 1 1.000 - - FOG0001418
OrthoInspector 1 1.000 - - otm46194
orthoMCL 1 0.900 - - OOG6_103176
Panther 1 1.100 - - O PTHR19384
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
1110.980

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