DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nos and fre-1

DIOPT Version :9

Sequence 1:	NP_523541.2	Gene:	Nos / 34495	FlyBaseID:	FBgn0011676	Length:	1349	Species:	Drosophila melanogaster
Sequence 2:	NP_001294725.1	Gene:	fre-1 / 180314	WormBaseID:	WBGene00001485	Length:	588	Species:	Caenorhabditis elegans

Alignment Length:	678	Identity:	166/678 - (24%)
Similarity:	268/678 - (39%)	Gaps:	150/678 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   673 VLYATETGKSEQYAKQL-CELLGHAFNAQIYCMSDYDISSIEHEALLIVVASTFGNGDPPENGEL 736
            :||.:|||.::..|:.| .|.......|:::.:.:||:|.:..|.:::.|.||.|.|:.|.|
Worm     5 ILYGSETGTAQDIAESLRREAQQRHLQARVHELDEYDVSQLPMEKVVLFVVSTTGQGEMPPN--- 66

  Fly   737 FSQELYAMRVQESSEHGLQDSSIGSSKSFMKASSRQEFMKLPLQQVKRIDRWDSLRGSTSDTFTE 801
                   ||              .:.|..::.|...:|:|
Worm    67 -------MR--------------KTWKLLLRKSLGADFLK------------------------- 85

  Fly   802 ETFGPLSNVRFAVFALGSSAYPNFCAFGQYVDNILGELGGERLLRVAYGDEM--CGQEQSFRKWA 864
                   ||...|..||.|:|..:...|:.:...|.:||.:.:..|...|:.  .|.:.:|..|.
Worm    86 -------NVNIGVLGLGDSSYQKYNFAGKKLYRRLVQLGAKMMCGVHLADDQHEIGIDGAFIPWK 143

  Fly   865 PEVFKLACETFCLDPEESLS---------DASLALQNDSLTVNTVRLVPSANKGSLDS------- 913
            .|.:|...|.     .|:||         |.|:     .:|.....|......|:.|.
Worm   144 TECWKKIKEI-----AENLSIYREMTAEIDTSV-----QITTKYRFLELGGESGNDDDDSDEDLE 198

  Fly   914 ---SLSKYHNKKVHCCKAKAKPHNLTRLSEGAKTTMLLEI-----CAPGLEYEPGDHVGIFPANR 970
               .:..|...||      .|...||. :|..:.|.|::.     ....:.::|||.:.:.|.|.
Worm   199 PQIEIPDYFPLKV------LKNRRLTS-AEHFQDTRLVDFEISDRNRSKMGFQPGDVLMVRPYNP 256

  Fly   971 TELVDGLLNRLVGVDNPDEVLQLQLLKEKQTSNGIFKCWEPHDKIPPD----------TLRNLLA 1025
            .|.|...:..| |:........|:::|..:.|           |.||:          ||...|.
Worm   257 EETVKIAIEAL-GLTEEQLKKPLKIVKNDRFS-----------KNPPNFLVGNFSAKTTLLTCLQ 309

  Fly  1026 RFFDLTTPPSRQLLTLLAGFCEDTADKERLELLVNDSSA--YEDW----RHWRLPHLLDVLEEFP 1084
            |:|||...|.|....:|..:..:..:||||:.|.:....  |.|:    |......|.|.:....
Worm   310 RYFDLQQVPKRSFFEMLGYYSTNPPEKERLQELASPEGLDDYLDYANRSRRTTAEALRDFVATSK 374

  Fly  1085 SCRPPAPLLLAQLTPLQPRFYSISSSPRRVSDEIHLTVAIVKYRCEDGQGDERYGVCSNYLSGLR 1149
            :.:|  ..|...||.::||.:||:|:|    ...||.:.:.|...:....|:|.|:||.::|.|:
Worm   375 NLKP--DYLFEILTTIRPRAFSIASAP----SPFHLELLVAKVEYKSRMADKRRGLCSTFISRLK 433

  Fly  1150 ADDELFMFVRSALGFHLPSDRSRPIILIGPGTGIAPFRSFWQEFQVLSDLDPTAKLPKMWLFFGC 1214
            ..||:|..:|... |..||..: |:|.||||||:|||||.:....:.|     |..|.: |||||
Worm   434 PGDEVFCKIRPGT-FKFPSPEA-PVICIGPGTGVAPFRSLFGHRSLFS-----AHFPGI-LFFGC 490

  Fly  1215 RNRDVDLY-AEEKAELQKDQILDRVFLALSREQAIPKTYVQDLIEQEFDSLYQLIVQERG-HIYV 1277
            |:...|.| ::|..||....::.    |.||:....|.|||..:.:....:.:::  :.| .:::
Worm   491 RSEHHDYYFSDEWPELSGVAVIP----AFSRDTDGRKVYVQHKMGENAGKIKRML--DLGAQVFI 549

  Fly  1278 CGDVTMAEHVYQTIRKCIAGKEQKSEAE 1305
            .|...........:...|.|.|....||
Worm   550 AGSSGDMPKAVSAVLAQIQGDEWTRRAE 577

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nos	NP_523541.2	NOS_oxygenase_euk	216..624	CDD:238410
		CysJ	669..1323	CDD:223446	166/678 (24%)
		Flavodoxin_1	673..863	CDD:278677	41/192 (21%)
		Nitric_oxide_synthase	931..1328	CDD:99799	109/398 (27%)
fre-1	NP_001294725.1	CysJ	3..587	CDD:223446	166/678 (24%)
		Flavodoxin_1	5..142	CDD:278677	41/192 (21%)
		FNR_like	210..587	CDD:297884	111/407 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910