DRSC/TRiP Functional Genomics Resources

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Protein Alignment Nos and nos1

DIOPT Version :10

Sequence 1:NP_523541.2 Gene:Nos / 34495 FlyBaseID:FBgn0011676 Length:1349 Species:Drosophila melanogaster
Sequence 2:XP_004910558.1 Gene:nos1 / 100497595 XenbaseID:XB-GENE-487610 Length:1420 Species:Xenopus tropicalis


Alignment Length:1155 Identity:563/1155 - (48%)
Similarity:760/1155 - (65%) Gaps:67/1155 - (5%)


- Green bases have known domain annotations that are detailed below.


  Fly   217 MRLKNIEGRPEVYDTLHCKGREILSCSKATCTSSIM---NIGNAAVEARKSDLILEHAKDFLEQY 278
            |:::|.|....:.||||||......|::..|..::|   :......:.|..:.:|..||:|::||
 Frog   292 MKIRNWETNTSLNDTLHCKASMPTPCTQQICMGAVMTPPHYVRKPEDVRTKEELLPLAKEFIDQY 356

  Fly   279 FTSIKRTSSTAHETRWKQVRQSIETTGHYQLTETELIYGAKLAWRNSSRCIGRIQWSKLQVFDCR 343
            ::|:||..|.||..|.::|.:.||.|..|||.:||||||||.||||:|||:||||||||||||.|
 Frog   357 YSSMKRFGSKAHMDRLQEVTKEIEATDTYQLRDTELIYGAKHAWRNASRCVGRIQWSKLQVFDAR 421

  Fly   344 YVTTTSGMFEAICNHIKYATNKGNLRSAITIFPQRTDAKHDYRIWNNQLISYAGYKQADGKIIGD 408
            ..||..|||..||||||||||||||||||||||||||.|.|:||||.|||.||||||.||.::||
 Frog   422 DCTTAHGMFNYICNHIKYATNKGNLRSAITIFPQRTDGKRDFRIWNAQLIRYAGYKQPDGSVLGD 486

  Fly   409 PMNVEFTEVCTKLGWKSKGSEWDILPLVVSANGHDPDYFDYPPELILEVPLTHPKFEWFSDLGLR 473
            |.|||.||:|.:.|||:....:|:|||::.|:|:||:.|:.|||||:||.:.||:.|||.||.|:
 Frog   487 PANVELTEICIQQGWKAPYGRFDVLPLLLQADGNDPELFEIPPELIMEVNIRHPRLEWFKDLALK 551

  Fly   474 WYALPAVSSMLFDVGGIQFTATTFSGWYMSTEIGSRNLCDTNRRNMLETVALKMQLDTRTPTSLW 538
            ||.|||||::|.:|||::|:|..||||||.||||.|:.||.:|.|:||.|||||.||||..:|||
 Frog   552 WYGLPAVSNLLLEVGGLEFSACPFSGWYMGTEIGVRDYCDNSRYNILEEVALKMNLDTRKTSSLW 616

  Fly   539 KDKAVVEMNIAVLHSYQSRNVTIVDHHTASESFMKHFENESKLRNGCPADWIWIVPPLSGSITPV 603
            ||:|:||:|||||:|:||..:||||||:|:|||:||.|||.:.|.||||||:|||||:|||||||
 Frog   617 KDQALVEINIAVLYSFQSDKITIVDHHSATESFIKHMENEYRCRGGCPADWVWIVPPMSGSITPV 681

  Fly   604 FHQEMALYYLKPSFEYQDPAWRTHVWKKGRGESKGKKPRRKFNFKQIARAVKFTSKLFGRALSKR 668
            |||||..|.|.||||||...|.||:||...|....|   |...||::|:||||::||.|:|::||
 Frog   682 FHQEMLNYRLTPSFEYQPDPWNTHIWKGVNGTPTKK---RAIGFKKLAKAVKFSAKLMGQAMAKR 743

  Fly   669 IKATVLYATETGKSEQYAKQLCELLGHAFNAQIYCMSDYDISSIEHEALLIVVASTFGNGDPPEN 733
            :|||:||||||||||.|||.|||:..|||:|::..|.||||..:|||.|::||.|||||||||||
 Frog   744 VKATILYATETGKSEVYAKTLCEIFKHAFDAKVMSMDDYDIVHLEHETLVLVVTSTFGNGDPPEN 808

  Fly   734 GELFSQELYAMR-----VQESSEHGLQDSSIGSSKSFMKASSRQEFMKLPLQQVKRIDRWDSLRG 793
            ||.|...|..||     ::|.:.:.::.:|:.||.                         |:.:.
 Frog   809 GEKFGCALMEMRHPNSNLEERTSYKVRFNSVSSSA-------------------------DAQKS 848

  Fly   794 STSDTFTEETF---GPLSNVRFAVFALGSSAYPNFCAFGQYVDNILGELGGERLLRVAYGDEMCG 855
            |..:|...:.|   |||:||||:.|.|||.|||:||||.:.||.:|.||||||:|::..|||:||
 Frog   849 SADETGPRDNFGSAGPLANVRFSAFGLGSRAYPHFCAFARAVDTLLEELGGERILKMGEGDELCG 913

  Fly   856 QEQSFRKWAPEVFKLACETFCLDPEESLSDASLAL-QND-SLTVNTVRLVPSANKGSLDSSLSKY 918
            ||:|||.||.:||:.||:.||:..:.|:..|:.:| .|| |...:..|:...|....|..:|...
 Frog   914 QEESFRTWAKKVFQAACDVFCVGDDVSIEKANNSLISNDRSWKRSKYRISYVAEAPELTQALYSI 978

  Fly   919 HNKKVHCCKAKAKPHNLTRLSEGAKTTMLL--------EICAPGLEYEPGDHVGIFPANRTELVD 975
            |.|||:..:..:: .|| :..:.:::|:.|        |:|     |:||||:||||.|..:||:
 Frog   979 HKKKVYGARLLSR-QNL-QSPKSSRSTIFLQLHTNEHKELC-----YKPGDHLGIFPGNHEDLVN 1036

  Fly   976 GLLNRLVGVDNPDEVLQLQLLKEKQTSNGIFKCWEPHDKIPPDTLRNLLARFFDLTTPPSRQLLT 1040
            .|:.:|......::::::::|:|:.|:.|:...|....:|||.|:......|.|:||||:..|:.
 Frog  1037 ALIEQLEDAPPVNQLVRVEMLEERNTALGVISNWTEEQRIPPCTIFQAFKYFLDITTPPTPLLMQ 1101

  Fly  1041 LLAGFCEDTADKERLELLVNDSSAYEDWRHWRLPHLLDVLEEFPSCRPPAPLLLAQLTPLQPRFY 1105
            .:|....|..:|.|||:|......||.|:.::.|.:::|||||||.:.|:.|||.||..||||:|
 Frog  1102 QIALLATDEKEKNRLEILSKGLQEYEQWKWYKNPTIVEVLEEFPSIQMPSSLLLTQLPLLQPRYY 1166

  Fly  1106 SISSSPRRVSDEIHLTVAIVKYRCEDGQGDERYGVCSNYLSGLRADDELFMFVRSALGFHLPSDR 1170
            ||||||....:|:|||||:|.||..||.|...:||||::|:.::.|:.:..|||.|..|.:|.|.
 Frog  1167 SISSSPEMYPEEVHLTVAVVTYRTRDGDGPIHHGVCSSWLNRIQPDEVVPCFVRGAPSFQMPEDP 1231

  Fly  1171 SRPIILIGPGTGIAPFRSFWQEFQVLSDLDPTAKLP-KMWLFFGCRNRDVD-LYAEEKAELQKDQ 1233
            ..|.|||||||||||||||||  |.|.|:......| .|.|.||||...:| :|.||........
 Frog  1232 QVPCILIGPGTGIAPFRSFWQ--QRLYDMQHRGLKPCPMILVFGCRESKIDHIYKEETMHAMNKG 1294

  Fly  1234 ILDRVFLALSREQAIPKTYVQDLI-EQEFDSLYQLIVQERGHIYVCGDVTMAEHVYQTIRKCIAG 1297
            :...:|.|.|||...||.||||:: ||..|..|:.:..:.||||:||||.||..|.::::..:..
 Frog  1295 VFKELFTAYSREPNKPKKYVQDVLREQLSDVTYKALKDQGGHIYICGDVNMAGDVLKSLQHIVKE 1359

  Fly  1298 KEQKSEAEVETFLLTLRDESRYHEDIFGITLRTAEIHTKSRATARIRMAS 1347
            :...:..|...|:..|||::||||||||:||||.|:      |.|:|..|
 Frog  1360 RGNLTAEEAGAFISKLRDDNRYHEDIFGVTLRTYEV------TNRLRSES 1403

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NosNP_523541.2 NOS_oxygenase_euk 216..624 CDD:238410 247/409 (60%)
Flavodoxin_1 673..863 CDD:425562 94/197 (48%)
Nitric_oxide_synthase 931..1328 CDD:99799 167/407 (41%)
nos1XP_004910558.1 PDZ_nNOS-like 14..123 CDD:467192
NOS_oxygenase_euk 291..702 CDD:238410 247/409 (60%)
Flavodoxin_1 748..921 CDD:425562 94/197 (48%)
Nitric_oxide_synthase 987..1390 CDD:99799 167/411 (41%)
Blue background indicates that the domain is not in the aligned region.

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