DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nos and ndor1

DIOPT Version :9

Sequence 1:	NP_523541.2	Gene:	Nos / 34495	FlyBaseID:	FBgn0011676	Length:	1349	Species:	Drosophila melanogaster
Sequence 2:	NP_001120408.1	Gene:	ndor1 / 100145485	XenbaseID:	XB-GENE-956252	Length:	598	Species:	Xenopus tropicalis

Alignment Length:	696	Identity:	172/696 - (24%)
Similarity:	292/696 - (41%)	Gaps:	154/696 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   673 VLYATETGKSEQYAKQL-CELLGHAFNAQIYCMSDYDISSIEHEALLIVVASTFGNGDPPENGEL 736
            :||.::||.:|..|.:| .|...|.|..::..:.:|.::.:.||.|::.|.:|.|.||||:|
Frog     8 ILYGSQTGTAEDLAGRLGREAKRHHFQCRMESLDEYRVADLIHEPLVVFVCATTGQGDPPDN--- 69

  Fly   737 FSQELYAMRVQESSEHGLQDSSIGSSKSFMKASSRQEFMKLPLQQVKRIDRWDSLRGSTSDTFTE 801
                                     .|:|.:...|:   .||...:.|:|
Frog    70 -------------------------MKNFWRFIFRR---NLPHNALCRMD--------------- 91

  Fly   802 ETFGPLSNVRFAVFALGSSAYPNFCAFGQYVDNILGELGGERLLRVAYGDEM--CGQEQSFRKWA 864
                      :||..||.|:||.|....:.:...|.:||...||..|.||:.  .|.:.:...|.
Frog    92 ----------YAVLGLGDSSYPKFNFIAKKLHKRLQQLGACPLLPPALGDDQHDLGPDAAVDPWL 146

  Fly   865 PEVFKLACETFCLDP--------------------EESLSDASLA---LQNDSLTVNTVRLVPSA 906
            .:::......:.|.|                    ||::....|:   |:.||  .||   .|::
Frog   147 KDLWSKILSIYPLPPGLNIISEDILLPPKYLLRLLEETIGQDDLSGEELERDS--NNT---TPAS 206

  Fly   907 NKGSLDSSLSKYHNKKVHCCKAKAKPH-NLTRLSEGAKTTMLLEICAPGLEYEPGDHVGIFPANR 970
            ......:.:  ..|::|     .|..| ...||.|       .:|....|::.|||...:.|.|
Frog   207 ESHPFPAPV--VSNQRV-----TALDHFQDVRLIE-------FDISGSALQFSPGDVAMVQPRN- 256

  Fly   971 TELVDGLLNRLVGVDNPDEVLQL-QLLKEKQTSNGIFKCWEPHDKIPP-----DTLRNLLARFFD 1029
                           :|..|.|| .||:....:..:.:..:|...:|.     ..:..|..|:.|
Frog   257 ---------------SPPHVQQLCSLLRLDPRTRFVVEASDPEAAVPAQLAELQCIGQLAERYLD 306

  Fly  1030 LTTPPSRQLLTLLAGFCEDTADKERLELLVNDSSAYEDWRHWRLPH--LLDVLEEFPSCRP--PA 1090
            |...|.|....||:.|..|..::|:|....:.....|.:.:...|.  ||:||.:||....  ||
Frog   307 LCAVPRRSFFQLLSHFAPDELEREKLREFGSAGGQEELFSYCNRPRRTLLEVLVDFPHTTRCIPA 371

  Fly  1091 PLLLAQLTPLQPRFYSISSSPRRVSDEIHLTVAIVKYRCEDGQGDERYGVCSNYLSGL--RADDE 1153
            ..||..:..::||.:||:||.:.:.:.:.:.||:|:||.:  ..:.|.|:||.:|:.|  |..:.
Frog   372 TYLLELIPRMRPRAFSIASSMQALPNALQILVAVVQYRSK--LIEPRRGLCSTWLASLPPRGRER 434

  Fly  1154 LFMFV-RSALGFHLPSDRSRPIILIGPGTGIAPFRSFWQEFQVLSDLDPTAKLPKMW--LFFGCR 1215
            :.::| |.::.|  |.:...|::::|||||:||||:..||         .|...|.|  ||||||
Frog   435 VPIWVKRGSMTF--PLEPGTPLVMVGPGTGVAPFRAAVQE---------RAANGKRWSCLFFGCR 488

  Fly  1216 NRDVDLYAEEKAELQKDQILD---RVFLALSREQAIPKTYVQDLIEQEFDSLYQLIVQERGHIYV 1277
            .:..|.|.|::.|   |.:..   .:|.|.||:|. .|.|||..|.:....|:.|:...:|:.|:
Frog   489 GKSKDFYFEKEWE---DLVTGGFLTLFTAFSRDQE-DKVYVQRRIRENSALLWDLLANRQGYFYI 549

  Fly  1278 CGDV-TMAEHVYQTIRKCIAGKEQKSEAEVETFLLTLRDESRYHED 1322
            .|:. :|...|...::..:..:...|..:.|.:::.:....|:..:
Frog   550 AGNAKSMPNEVTDALKWVLQSEGGLSAPDAEQYVVAMEKSRRFQSE 595

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nos	NP_523541.2	NOS_oxygenase_euk	216..624	CDD:238410
		CysJ	669..1323	CDD:223446	172/696 (25%)
		Flavodoxin_1	673..863	CDD:278677	46/192 (24%)
		Nitric_oxide_synthase	931..1328	CDD:99799	111/412 (27%)
ndor1	NP_001120408.1	CysJ	4..597	CDD:223446	172/696 (25%)
		Flavodoxin_1	8..145	CDD:278677	46/192 (24%)
		FNR_like	214..597	CDD:297884	114/429 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000