DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17134 and PEP4

DIOPT Version :9

Sequence 1:	NP_609458.1	Gene:	CG17134 / 34494	FlyBaseID:	FBgn0032304	Length:	391	Species:	Drosophila melanogaster
Sequence 2:	NP_015171.1	Gene:	PEP4 / 855949	SGDID:	S000006075	Length:	405	Species:	Saccharomyces cerevisiae

Alignment Length:	421	Identity:	160/421 - (38%)
Similarity:	222/421 - (52%)	Gaps:	55/421 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MRQLLVL-LVLVGIGHSAAKLNRVQLQVNK-----------------------NFTKTHGSVKAE 41
            ::.||.| |:||.....|||:::.::..::                       .|.|.:..|
Yeast     4 LKALLPLALLLVSANQVAAKVHKAKIYKHELSDEMKEVTFEQHLAHLGQKYLTQFEKANPEV--- 65

  Fly    42 KTVLASKYSFLAETSFSVSSSGATENLHNSMNNEYYGVIAIGTPEQRFNILFDTGSANLWVPSAS 106
              |.:.::.|..|....|.       |.|.:|.:||..|.:|||.|.|.::.||||:||||||..
Yeast    66 --VFSREHPFFTEGGHDVP-------LTNYLNAQYYTDITLGTPPQNFKVILDTGSSNLWVPSNE 121

  Fly   107 CPASNTACQRHNKYDSSASSTYVANGEEFAIEYGTGSLSGFLSNDIVTIAGISIQNQTFGEALSE 171
            |  .:.||..|:|||..|||:|.|||.||||:||||||.|::|.|.::|..::|..|.|.||.||
Yeast   122 C--GSLACFLHSKYDHEASSSYKANGTEFAIQYGTGSLEGYISQDTLSIGDLTIPKQDFAEATSE 184

  Fly   172 PGTTFVDAPFAGILGLAFSAIAVDGVTPPFDNMISQGLLDEPVISFYL-KRQGTAVRGGELILGG 235
            ||.||....|.|||||.:..|:||.|.|||.|.|.|.||||...:||| ........|||...||
Yeast   185 PGLTFAFGKFDGILGLGYDTISVDKVVPPFYNAIQQDLLDEKRFAFYLGDTSKDTENGGEATFGG 249

  Fly   236 IDSSLYRGSLTYVPVSVPAYWQFKVNTIKTN---GTLLCNGCQAIADTGTSLIAVPLAAYRKINR 297
            ||.|.::|.:|::||...|||:.|...|...   ..|..:|  |..|||||||.:|......||.
Yeast   250 IDESKFKGDITWLPVRRKAYWEVKFEGIGLGDEYAELESHG--AAIDTGTSLITLPSGLAEMINA 312

  Fly   298 QLGATDN-DGEAFVRCGRVSSLPKVNLNIGGTVFTLAPRDYIVKVTQNGQTYCMSAFTYME---- 357
            ::||... .|:..:.|....:||.:..|..|..||:.|.||.::|:.:    |:||.|.|:
Yeast   313 EIGAKKGWTGQYTLDCNTRDNLPDLIFNFNGYNFTIGPYDYTLEVSGS----CISAITPMDFPEP 373

  Fly   358 -GLSFWILGDVFIGKFYTVFDKGNERIGFAR 387
             | ...|:||.|:.|:|:::|.||..:|.|:
Yeast   374 VG-PLAIVGDAFLRKYYSIYDLGNNAVGLAK 403

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17134	NP_609458.1	pepsin_retropepsin_like	70..386	CDD:299705	142/325 (44%)
CG17134	NP_609458.1	Asp	75..388	CDD:278455	141/323 (44%)
PEP4	NP_015171.1	Proteinase_A_fungi	81..403	CDD:133155	144/337 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	303	1.000	Domainoid score	I215
eggNOG	1	0.900	-	-		E1_KOG1339
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	319	1.000	Inparanoid score	I453
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54317
OrthoFinder	1	1.000	-	-		FOG0000066
OrthoInspector	1	1.000	-	-		otm46649
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR47966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	9	8.930