DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17134 and ctsd

DIOPT Version :9

Sequence 1:	NP_609458.1	Gene:	CG17134 / 34494	FlyBaseID:	FBgn0032304	Length:	391	Species:	Drosophila melanogaster
Sequence 2:	NP_571785.2	Gene:	ctsd / 65225	ZFINID:	ZDB-GENE-010131-8	Length:	398	Species:	Danio rerio

Alignment Length:	396	Identity:	171/396 - (43%)
Similarity:	243/396 - (61%)	Gaps:	14/396 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 QLLVLLVLVGIGHSAAKLNRVQLQVNKNFTKT-HGSVKAEKTVLASKYSFLAETSFSVSSSGATE 66
            ::..||::|....::..:.|:.|:..:...:| ..|.::.:.:::|..|......|..|:....|
Zfish     2 RIAFLLLVVAFFCTSDAIVRIPLKKFRTLRRTLSDSGRSLEELVSSSNSLKYNLGFPASNDPTPE 66

  Fly    67 NLHNSMNNEYYGVIAIGTPEQRFNILFDTGSANLWVPSASCPASNTACQRHNKYDSSASSTYVAN 131
            .|.|.::.:|||.|.:|||.|.|.::|||||:||||||..|..::.||..|:||:...|||||.|
Zfish    67 TLKNYLDAQYYGEIGLGTPVQTFTVVFDTGSSNLWVPSVHCSLTDIACLLHHKYNGGKSSTYVKN 131

  Fly   132 GEEFAIEYGTGSLSGFLSNDIVTIAGISIQNQTFGEALSEPGTTFVDAPFAGILGLAFSAIAVDG 196
            |.:|||:||:|||||:||.|..||..|:::.|.||||:.:||..|:.|.|.||||:|:..|||||
Zfish   132 GTQFAIQYGSGSLSGYLSQDTCTIGDIAVEKQIFGEAIKQPGVAFIAAKFDGILGMAYPRIAVDG 196

  Fly   197 VTPPFDNMISQGLLDEPVISFYLKRQGTAVRGGELILGGIDSSLYRGSLTYVPVSVPAYWQFKVN 261
            |.|.||.|:||..:::.|.||||.|......||||:|||.|...|.|...||.:|..||||..::
Zfish   197 VPPVFDMMMSQKKVEKNVFSFYLNRNPDTQPGGELLLGGTDPKYYTGDFNYVDISRQAYWQIHMD 261

  Fly   262 TIKT-NGTLLC-NGCQAIADTGTSLIAVPLAAYRKINRQLGATD-NDGEAFVRCGRVSSLPKVNL 323
            .:.. :|..|| .||:||.|||||||..|.|..:.:.:.:||.. ..||..|.|.:|.:||.::.
Zfish   262 GMSIGSGLSLCKGGCEAIVDTGTSLITGPAAEVKALQKAIGAIPLMQGEYMVDCKKVPTLPTISF 326

  Fly   324 NIGGTVFTLAPRDYIVKVTQNGQTYCMSAFTYMEGLS-------FWILGDVFIGKFYTVFDKGNE 381
            ::||.|::|....||:|.:|.|...|:|.|.   ||.       .|||||||||::|||||:.|.
Zfish   327 SLGGKVYSLTGEQYILKESQGGHDICLSGFM---GLDIPPPAGPLWILGDVFIGQYYTVFDRENN 388

  Fly   382 RIGFAR 387
            |:|||:
Zfish   389 RVGFAK 394

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17134	NP_609458.1	pepsin_retropepsin_like	70..386	CDD:299705	156/325 (48%)
CG17134	NP_609458.1	Asp	75..388	CDD:278455	157/323 (49%)
ctsd	NP_571785.2	A1_Propeptide	19..44	CDD:285240	4/24 (17%)
		Cathepsin_D2	70..394	CDD:133157	157/326 (48%)
		Asp	75..395	CDD:278455	157/323 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1339
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54317
OrthoDB	1	1.010	-	-		D1619495at2759
OrthoFinder	1	1.000	-	-		FOG0000066
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR47966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	8	7.890