Protein Alignment CG17134 and PGA4

DIOPT Version :9

• Sequence 1: NP_609458.1
• Gene: CG17134 / 34494
• FlyBaseID: FBgn0032304
• Length: 391
• Species: Drosophila melanogaster
• Sequence 2: NP_001073276.1
• Gene: PGA4 / 643847
• HGNCID: 8886
• Length: 388
• Species: Homo sapiens
• Alignment Length: 403
• Identity: 168/403 - (41%)
• Similarity: 231/403 - (57%)
• Gaps: 36/403 - (8%)

  Fly     5 LVLLVLVGIGHSAAKLNRVQLQVNKNFTKTHGSVKAEKTVL-----------ASKYSFLAETSFS 58
            |:||.||.:  |...:.:|.|...|:..:|    .:|:.:|           |.||....|....
Human     4 LLLLGLVAL--SECIMYKVPLIRKKSLRRT----LSERGLLKDFLKKHNLNPARKYFPQWEAPTL 62

  Fly    59 VSSSGATENLHNSMNNEYYGVIAIGTPEQRFNILFDTGSANLWVPSASCPASNTACQRHNKYDSS 123
            |..    :.|.|.::.||:|.|.||||.|.|.::|||||:||||||..|  |:.||..||:::..
Human    63 VDE----QPLENYLDMEYFGTIGIGTPAQDFTVVFDTGSSNLWVPSVYC--SSLACTNHNRFNPE 121

  Fly   124 ASSTYVANGEEFAIEYGTGSLSGFLSNDIVTIAGISIQNQTFGEALSEPGTTFVDAPFAGILGLA 188
            .||||.:..|..:|.|||||::|.|..|.|.:.|||..||.||.:.:|||:....|||.||||||
Human   122 DSSTYQSTSETVSITYGTGSMTGILGYDTVQVGGISDTNQIFGLSETEPGSFLYYAPFDGILGLA 186

  Fly   189 FSAIAVDGVTPPFDNMISQGLLDEPVISFYLKRQGTAVRGGELILGGIDSSLYRGSLTYVPVSVP 253
            :.:|:..|.||.|||:.:|||:.:.:.|.||.....:  |..:|.||||||.|.|||.:|||:|.
Human   187 YPSISSSGATPVFDNIWNQGLVSQDLFSVYLSADDQS--GSVVIFGGIDSSYYTGSLNWVPVTVE 249

  Fly   254 AYWQFKVNTIKTNG-TLLC-NGCQAIADTGTSLIAVPLAAYRKINRQLGATDN-DGEAFVRCGRV 315
            .|||..|::|..|| .:.| .|||||.||||||:..|.:....|...:||::| ||:..|.|..:
Human   250 GYWQITVDSITMNGEAIACAEGCQAIVDTGTSLLTGPTSPIANIQSDIGASENSDGDMVVSCSAI 314

  Fly   316 SSLPKVNLNIGGTVFTLAPRDYIVKVTQNGQTYCMSAFTYM----EGLSFWILGDVFIGKFYTVF 376
            ||||.:...|.|..:.:.|..||::    .:..|:|.|..|    |....||||||||.:::|||
Human   315 SSLPDIVFTINGVQYPVPPSAYILQ----SEGSCISGFQGMNLPTESGELWILGDVFIRQYFTVF 375

  Fly   377 DKGNERIGFARVA 389
            |:.|.::|.|.||
Human   376 DRANNQVGLAPVA 388

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG17134	NP_609458.1	pepsin_retropepsin_like	70..386	CDD:299705	147/322 (46%)
		Asp	75..388	CDD:278455	147/319 (46%)
PGA4	NP_001073276.1	A1_Propeptide	17..45	CDD:311771	6/31 (19%)
		pepsin_A	66..386	CDD:133145	148/327 (45%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151451
Domainoid	1	1.000	297	1.000	Domainoid score	I1463
eggNOG	1	0.900	-	-		E1_KOG1339
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	319	1.000	Inparanoid score	I2536
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54317
OrthoDB	1	1.010	-	-		D1619495at2759
OrthoFinder	1	1.000	-	-		FOG0000066
OrthoInspector	1	1.000	-	-		mtm8487
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR47966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1456
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	11	10.910