DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17134 and PGA3

DIOPT Version :9

Sequence 1:	NP_609458.1	Gene:	CG17134 / 34494	FlyBaseID:	FBgn0032304	Length:	391	Species:	Drosophila melanogaster
Sequence 2:	NP_001073275.1	Gene:	PGA3 / 643834	HGNCID:	8885	Length:	388	Species:	Homo sapiens

Alignment Length:	368	Identity:	159/368 - (43%)
Similarity:	215/368 - (58%)	Gaps:	25/368 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 KNFTKTHGSVKAEKTVLASKYSFLAETSFSVSSSGATENLHNSMNNEYYGVIAIGTPEQRFNILF 93
            |:|.|.|....|.|.....|...|.:          .:.|.|.::.||:|.|.||||.|.|.::|
Human    39 KDFLKKHNLNPARKYFPQWKAPTLVD----------EQPLENYLDMEYFGTIGIGTPAQDFTVVF 93

  Fly    94 DTGSANLWVPSASCPASNTACQRHNKYDSSASSTYVANGEEFAIEYGTGSLSGFLSNDIVTIAGI 158
            ||||:||||||..|  |:.||..||:::...||||.:..|..:|.|||||::|.|..|.|.:.||
Human    94 DTGSSNLWVPSVYC--SSLACTNHNRFNPEDSSTYQSTSETVSITYGTGSMTGILGYDTVQVGGI 156

  Fly   159 SIQNQTFGEALSEPGTTFVDAPFAGILGLAFSAIAVDGVTPPFDNMISQGLLDEPVISFYLKRQG 223
            |..||.||.:.:|||:....|||.||||||:.:|:..|.||.|||:.:|||:.:.:.|.||....
Human   157 SDTNQIFGLSETEPGSFLYYAPFDGILGLAYPSISSSGATPVFDNIWNQGLVSQDLFSVYLSADD 221

  Fly   224 TAVRGGELILGGIDSSLYRGSLTYVPVSVPAYWQFKVNTIKTNG-TLLC-NGCQAIADTGTSLIA 286
            .:  |..:|.||||||.|.|||.:|||:|..|||..|::|..|| .:.| .|||||.||||||:.
Human   222 QS--GSVVIFGGIDSSYYTGSLNWVPVTVEGYWQITVDSITMNGEAIACAEGCQAIVDTGTSLLT 284

  Fly   287 VPLAAYRKINRQLGATDN-DGEAFVRCGRVSSLPKVNLNIGGTVFTLAPRDYIVKVTQNGQTYCM 350
            .|.:....|...:||::| ||:..|.|..:||||.:...|.|..:.:.|..||::    .:..|:
Human   285 GPTSPIANIQSDIGASENSDGDMVVSCSAISSLPDIVFTINGVQYPVPPSAYILQ----SEGSCI 345

  Fly   351 SAFTYM----EGLSFWILGDVFIGKFYTVFDKGNERIGFARVA 389
            |.|..|    |....||||||||.:::||||:.|.::|.|.||
Human   346 SGFQGMNLPTESGELWILGDVFIRQYFTVFDRANNQVGLAPVA 388

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17134	NP_609458.1	pepsin_retropepsin_like	70..386	CDD:299705	147/322 (46%)
CG17134	NP_609458.1	Asp	75..388	CDD:278455	147/319 (46%)
PGA3	NP_001073275.1	A1_Propeptide	17..45	CDD:285240	3/5 (60%)
		pepsin_A	66..386	CDD:133145	148/327 (45%)
		Asp	75..387	CDD:278455	147/319 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151450
Domainoid	1	1.000	297	1.000	Domainoid score	I1463
eggNOG	1	0.900	-	-		E1_KOG1339
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	319	1.000	Inparanoid score	I2536
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54317
OrthoDB	1	1.010	-	-		D1619495at2759
OrthoFinder	1	1.000	-	-		FOG0000066
OrthoInspector	1	1.000	-	-		mtm8487
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR47966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1456
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	11	10.910