Protein Alignment CG17134 and REN

DIOPT Version :10

• Sequence 1: NP_609458.1
• Gene: CG17134 / 34494
• FlyBaseID: FBgn0032304
• Length: 391
• Species: Drosophila melanogaster
• Sequence 2: NP_000528.1
• Gene: REN / 5972
• HGNCID: 9958
• Length: 406
• Species: Homo sapiens
• Alignment Length: 344
• Identity: 140/344 - (40%)
• Similarity: 199/344 - (57%)
• Gaps: 18/344 - (5%)

  Fly    52 LAETSFSVSSSGATENLHNSMNNEYYGVIAIGTPEQRFNILFDTGSANLWVPSASCPASNTACQR 116
            |..|:.||.       |.|.|:.:|||.|.||||.|.|.::|||||:|:||||:.|....|||..
Human    69 LGNTTSSVI-------LTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRLYTACVY 126

  Fly   117 HNKYDSSASSTYVANGEEFAIEYGTGSLSGFLSNDIVTIAGISIQNQTFGEALSEPGTTFVDAPF 181
            |..:|:|.||:|..||.|..:.|.||::|||||.||:|:.||:: .|.|||....|...|:.|.|
Human   127 HKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITV-TQMFGEVTEMPALPFMLAEF 190

  Fly   182 AGILGLAFSAIAVDGVTPPFDNMISQGLLDEPVISFYLKR--QGTAVRGGELILGGIDSSLYRGS 244
            .|::|:.|...|:..|||.|||:||||:|.|.|.|||..|  :.:...||:::|||.|...|.|:
Human   191 DGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGGQIVLGGSDPQHYEGN 255

  Fly   245 LTYVPVSVPAYWQFKVNTIKT-NGTLLC-NGCQAIADTGTSLIAVPLAAYRKINRQLGATDNDGE 307
            ..|:.:.....||.::..:.. :.|||| :||.|:.|||.|.|:...::..|:...|||.....:
Human   256 FHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISGSTSSIEKLMEALGAKKRLFD 320

  Fly   308 AFVRCGRVSSLPKVNLNIGGTVFTLAPRDYIVKVTQNGQTYCMSAFTYME-----GLSFWILGDV 367
            ..|:|....:||.::.::||..:||...||:.:.:.:.:..|..|...|:     |.: |.||..
Human   321 YVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKKLCTLAIHAMDIPPPTGPT-WALGAT 384

  Fly   368 FIGKFYTVFDKGNERIGFA 386
            ||.||||.||:.|.|||||
Human   385 FIRKFYTEFDRRNNRIGFA 403

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG17134	NP_609458.1	pepsin_retropepsin_like	70..386	CDD:472175	133/324 (41%)
REN	NP_000528.1	A1_Propeptide	33..>51	CDD:462326
		renin_like	78..405	CDD:133154	136/328 (41%)