Protein Alignment CG17134 and PGC

DIOPT Version :10

• Sequence 1: NP_609458.1
• Gene: CG17134 / 34494
• FlyBaseID: FBgn0032304
• Length: 391
• Species: Drosophila melanogaster
• Sequence 2: NP_002621.1
• Gene: PGC / 5225
• HGNCID: 8890
• Length: 388
• Species: Homo sapiens
• Alignment Length: 410
• Identity: 160/410 - (39%)
• Similarity: 229/410 - (55%)
• Gaps: 43/410 - (10%)

  Fly     1 MRQLLVLLVLVGIGHSAAKLNRVQLQVNKNFTKTHGSVKAEKTVL-----------ASKYSFLAE 54
            |:.::|:||.:.:..:|  :.:|.|:..|:..:|    ..||.:|           |.||.|
Human     1 MKWMVVVLVCLQLLEAA--VVKVPLKKFKSIRET----MKEKGLLGEFLRTHKYDPAWKYRF--- 56

  Fly    55 TSFSVSSSGATENLHNSMNNEYYGVIAIGTPEQRFNILFDTGSANLWVPSASCPASNTACQRHNK 119
                 .....|......|:..|:|.|:||||.|.|.:||||||:||||||..|  .:.||..|::
Human    57 -----GDLSVTYEPMAYMDAAYFGEISIGTPPQNFLVLFDTGSSNLWVPSVYC--QSQACTSHSR 114

  Fly   120 YDSSASSTYVANGEEFAIEYGTGSLSGFLSNDIVTIAGISIQNQTFGEALSEPGTTFVDAPFAGI 184
            ::.|.||||..||:.|:::||:|||:||...|.:|:..|.:.||.||.:.:||||.||.|.|.||
Human   115 FNPSESSTYSTNGQTFSLQYGSGSLTGFFGYDTLTVQSIQVPNQEFGLSENEPGTNFVYAQFDGI 179

  Fly   185 LGLAFSAIAVDGVTPPFDNMISQGLLDEPVISFYL-KRQGTAVRGGELILGGIDSSLYRGSLTYV 248
            :|||:.|::||..|.....|:.:|.|..||.|.|| .:||::  ||.::.||:|||||.|.:.:.
Human   180 MGLAYPALSVDEATTAMQGMVQEGALTSPVFSVYLSNQQGSS--GGAVVFGGVDSSLYTGQIYWA 242

  Fly   249 PVSVPAYWQFKVNTIKTNGTL--LCN-GCQAIADTGTSLIAVPLAAYRKINRQLGATDND-GEAF 309
            ||:...|||..:......|..  .|: |||||.||||||:.||......:.:..||.::: |:..
Human   243 PVTQELYWQIGIEEFLIGGQASGWCSEGCQAIVDTGTSLLTVPQQYMSALLQATGAQEDEYGQFL 307

  Fly   310 VRCGRVSSLPKVNLNIGGTVFTLAPRDYIVKVTQNGQTYCMSAF--TYM---EGLSFWILGDVFI 369
            |.|..:.:||.:...|.|..|.|.|..||  ::.||  ||....  ||:   .|...|||||||:
Human   308 VNCNSIQNLPSLTFIINGVEFPLPPSSYI--LSNNG--YCTVGVEPTYLSSQNGQPLWILGDVFL 368

  Fly   370 GKFYTVFDKGNERIGFARVA 389
            ..:|:|:|.||.|:|||..|
Human   369 RSYYSVYDLGNNRVGFATAA 388

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG17134	NP_609458.1	pepsin_retropepsin_like	70..386	CDD:472175	140/325 (43%)
PGC	NP_002621.1	A1_Propeptide	20..46	CDD:462326	7/29 (24%)
		gastricsin	70..387	CDD:133144	141/324 (44%)