Protein Alignment CG17134 and bace2

DIOPT Version :9

• Sequence 1: NP_609458.1
• Gene: CG17134 / 34494
• FlyBaseID: FBgn0032304
• Length: 391
• Species: Drosophila melanogaster
• Sequence 2: XP_009289748.1
• Gene: bace2 / 449818
• ZFINID: ZDB-GENE-041010-68
• Length: 503
• Species: Danio rerio
• Alignment Length: 427
• Identity: 120/427 - (28%)
• Similarity: 185/427 - (43%)
• Gaps: 80/427 - (18%)

  Fly    25 LQVNKNFTKTHGSVKAEKTVLASKYS--------------FLAETSFSVSSSGA--------TEN 67
            |.::..|.|:|...|....:.|.|::              ..|::..|::|..|        ..|
Zfish     7 LLLSLTFWKSHSVFKIPLNIFAGKFNASVQLDLRPLQKNEAAAKSGLSLASDPAGIVNFLDMINN 71

  Fly    68 LHNSMNNEYYGVIAIGTPEQRFNILFDTGSANLWVPSASCPASNTACQRHNKYDSSASSTYVANG 132
            |.......||..:.||||.|..|||.||||:|..|.:|:.|...      :.::.:.||||.:..
Zfish    72 LKGDSGRGYYMQMIIGTPGQTLNILVDTGSSNFAVAAAAHPYIT------HYFNRALSSTYQSTE 130

  Fly   133 EEFAIEYGTGSLSGFLSNDIVTI----AG---ISIQNQTFGEALSEPGTTFVDAPFAGILGLAFS 190
            ...|::|..|...|.|..|::||    :|   |:|......|....||..     :.||||||:.
Zfish   131 RAVAVKYTQGEWEGELGTDLITIPEGPSGAITINIAAILTSEGFFLPGIN-----WQGILGLAYP 190

  Fly   191 AIA--VDGVTPPFDNMISQ-GLLDEPVISFYLKRQGTAV--------RGGELILGGIDSSLYRGS 244
            .:|  ...|.|.|::::.| |:.|    .|.|:..|..|        .||.||:||::.:|:||.
Zfish   191 LLARPDPSVEPFFNSVVRQTGIPD----VFSLQMCGAGVPASTTGDPAGGSLIMGGVEPTLHRGP 251

  Fly   245 LTYVPVSVPAYWQFKVNTIKT---NGTLLC---NGCQAIADTGTSLIAVPLAAYRKI---NRQLG 300
            :.|.||....|:|.:|..::.   |..|.|   |..:||.|:||:|:.:|...:..:   ..|..
Zfish   252 IWYTPVLEEWYYQVEVLKLEVGDQNLNLDCKEYNSDKAIVDSGTTLLRLPANVFTAVVDTIMQTS 316

  Fly   301 ATDN------DGEAFVRCGRVSS----LPKVNLNIGGT------VFTLAPRDYIVKVTQNGQTYC 349
            ..|:      ||.......|..|    .|||::.:.||      ..|:.|:.||..||....|..
Zfish   317 LIDDFSAGFFDGTKLACWMRGESPWRFFPKVSIYLRGTNTSQSFRITILPQLYIQPVTDIDGTLD 381

  Fly   350 MSAFTYMEGLSFWILGDVFIGKFYTVFDKGNERIGFA 386
            ...|......:..::|...:..||.:||:..:|:|||
Zfish   382 CFRFGISPSANGLVIGATVMEGFYVIFDRAQKRVGFA 418

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG17134	NP_609458.1	pepsin_retropepsin_like	70..386	CDD:299705	105/358 (29%)
		Asp	75..388	CDD:278455	107/355 (30%)
bace2	XP_009289748.1	beta_secretase_like	77..439	CDD:133140	107/357 (30%)
		Asp	80..418	CDD:278455	105/352 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170585938
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1339
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.740