DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17134 and ren

DIOPT Version :9

Sequence 1:	NP_609458.1	Gene:	CG17134 / 34494	FlyBaseID:	FBgn0032304	Length:	391	Species:	Drosophila melanogaster
Sequence 2:	NP_998025.1	Gene:	ren / 405786	ZFINID:	ZDB-GENE-040630-3	Length:	395	Species:	Danio rerio

Alignment Length:	398	Identity:	152/398 - (38%)
Similarity:	223/398 - (56%)	Gaps:	25/398 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 LVLLVLVGIGHSAAKLNRVQL-------QVNKNFTKTHGSVKAEKTVLASKYSFLAETSFSVSSS 62
            |.||:|.....|...|.||:|       :..|..:.|...|.:|   :..||.     ..|.::.
Zfish     6 LTLLILSLSAISTKALWRVKLKKMPSIRETLKEMSVTPAQVLSE---IMPKYQ-----EPSPTNG 62

  Fly    63 GATENLHNSMNNEYYGVIAIGTPEQRFNILFDTGSANLWVPSASCPASNTACQRHNKYDSSASST 127
            .|...|.|.::.:|:|.|:||:|.|.||::||||||||||||.||....|||..||:||:|.|.|
Zfish    63 TAPTPLINYLDTQYFGEISIGSPAQMFNVVFDTGSANLWVPSHSCSPLYTACFTHNRYDASKSLT 127

  Fly   128 YVANGEEFAIEYGTGSLSGFLSNDIVTIAGISIQNQTFGEALSEPGTTFVDAPFAGILGLAFSAI 192
            ::.||..|:|:|.:|::.||||.|:|.:.||.:. |.|.||.:.|...|:.|.|.|:||:.:..:
Zfish   128 HIFNGTGFSIQYASGNVRGFLSEDVVVVGGIPVV-QVFAEATALPAIPFILAKFDGVLGMGYPNV 191

  Fly   193 AVDGVTPPFDNMISQGLLDEPVISFYLKRQGTAVRGGELILGGIDSSLYRGSLTYVPVSVPAYWQ 257
            |:||:||.||.::||.:|.|.|.|.|..|..|.:.||||:|||.|.:.:.|...|:.......|:
Zfish   192 AIDGITPVFDRIMSQHVLKENVFSVYYSRDPTHIPGGELVLGGTDPNYHTGPFHYINTKEQGKWE 256

  Fly   258 FKVNTIKTNGTLL-C-NGCQAIADTGTSLIAVPLAAYRKINRQLGATD-NDGEAFVRCGRVSSLP 319
            ..:..:.....:| | :||.|:.|||:|.|..|.::...:.:.:||.: .:|...|.|..|..||
Zfish   257 VIMKGVSVGADILFCKDGCTAVIDTGSSYITGPASSISILMKTIGAVELAEGGYTVSCNVVRLLP 321

  Fly   320 KVNLNIGGTVFTLAPRDYIVKVTQNGQTYCMSAFTYME-----GLSFWILGDVFIGKFYTVFDKG 379
            .|..::||..::|...|||:..::.|:..|...|..::     | ..||||..||.::||.||:|
Zfish   322 TVAFHLGGQEYSLTDEDYILWQSEFGEDICTVTFKALDVPPPTG-PVWILGANFIARYYTEFDRG 385

  Fly   380 NERIGFAR 387
            |.||||||
Zfish   386 NNRIGFAR 393

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17134	NP_609458.1	pepsin_retropepsin_like	70..386	CDD:299705	131/323 (41%)
CG17134	NP_609458.1	Asp	75..388	CDD:278455	133/321 (41%)
ren	NP_998025.1	A1_Propeptide	23..>38	CDD:285240	3/14 (21%)
		renin_like	68..394	CDD:133154	135/328 (41%)
		Asp	75..394	CDD:278455	133/321 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170585922
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1339
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54317
OrthoDB	1	1.010	-	-		D1619495at2759
OrthoFinder	1	1.000	-	-		FOG0000066
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR47966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	8	7.820