DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17134 and CG10104

DIOPT Version :9

Sequence 1:	NP_609458.1	Gene:	CG17134 / 34494	FlyBaseID:	FBgn0032304	Length:	391	Species:	Drosophila melanogaster
Sequence 2:	NP_610961.1	Gene:	CG10104 / 36602	FlyBaseID:	FBgn0033933	Length:	404	Species:	Drosophila melanogaster

Alignment Length:	402	Identity:	165/402 - (41%)
Similarity:	230/402 - (57%)	Gaps:	28/402 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LLVLLVL-VGIGHSAA---KLNRVQLQ----VNKNFTKTHGSVKAEKTVLASKYS-----FLAET 55
            |.||.:| |...|..:   :|.||.|:    ....|.|.  .::.::  |..||:     |..|.
  Fly     8 LPVLFILPVQFQHPVSCKLQLYRVPLRRFPSARHRFEKL--GIRMDR--LRLKYAEEVSHFRGEW 68

  Fly    56 SFSVSSSGATENLHNSMNNEYYGVIAIGTPEQRFNILFDTGSANLWVPSASCPASNTACQRHNKY 120
            :.:|.|:    .|.|.::.:|:|.|.||||.|.|.::|||||:|||||||:|.::..||:.||:|
  Fly    69 NSAVKST----PLSNYLDAQYFGPITIGTPPQTFKVIFDTGSSNLWVPSATCASTMVACRVHNRY 129

  Fly   121 DSSASSTYVANGEEFAIEYGTGSLSGFLSNDIVTIAGISIQNQTFGEALSEPGTTFVDAPFAGIL 185
            .:..|:::...|:.|||.||:||||||||.|.|.:||:.|::|||.||...||..|:.|.|.||.
  Fly   130 FAKRSTSHQVRGDHFAIHYGSGSLSGFLSTDTVRVAGLEIRDQTFAEATEMPGPIFLAAKFDGIF 194

  Fly   186 GLAFSAIAVDGVTPPFDNMISQGLLDEPVISFYLKRQGTAVRGGELILGGIDSSLYRGSLTYVPV 250
            |||:.:|::..:.|||..|:.||||.:|:.|.||.|.|.. .||.:..||.:...|.|:.|||.|
  Fly   195 GLAYRSISMQRIKPPFYAMMEQGLLTKPIFSVYLSRNGEK-DGGAIFFGGSNPHYYTGNFTYVQV 258

  Fly   251 SVPAYWQFKVNTIKTNGTLLC-NGCQAIADTGTSLIAVPLAAYRKINRQLGATDND-GEAFVRCG 313
            |..||||.|:::.......|| .||:.|.|||||.:|:|......||..:|.|.:. |:..|.|.
  Fly   259 SHRAYWQVKMDSAVIRNLELCQQGCEVIIDTGTSFLALPYDQAILINESIGGTPSSFGQFLVPCD 323

  Fly   314 RVSSLPKVNLNIGGTVFTLAPRDYIVKVTQNGQTYCMSAFTYMEGLS----FWILGDVFIGKFYT 374
            .|..|||:...:||..|.|...:|:.:.....:..|.|||..::..|    .|||||||:||:||
  Fly   324 SVPDLPKITFTLGGRRFFLESHEYVFRDIYQDRRICSSAFIAVDLPSPSGPLWILGDVFLGKYYT 388

  Fly   375 VFDKGNERIGFA 386
            .||....|||||
  Fly   389 EFDMERHRIGFA 400

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17134	NP_609458.1	pepsin_retropepsin_like	70..386	CDD:299705	143/321 (45%)
CG17134	NP_609458.1	Asp	75..388	CDD:278455	144/318 (45%)
CG10104	NP_610961.1	A1_Propeptide	28..54	CDD:285240	6/29 (21%)
		pepsin_retropepsin_like	76..400	CDD:299705	144/324 (44%)
		Asp	84..402	CDD:278455	144/318 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45455540
Domainoid	1	1.000	97	1.000	Domainoid score	I1884
eggNOG	1	0.900	-	-		E1_KOG1339
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	97	1.000	Inparanoid score	I1684
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1619495at2759
OrthoFinder	1	1.000	-	-		FOG0000066
OrthoInspector	1	1.000	-	-		mtm978
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR47966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	9	8.900