Protein Alignment CG17134 and Bace2

DIOPT Version :10

• Sequence 1: NP_609458.1
• Gene: CG17134 / 34494
• FlyBaseID: FBgn0032304
• Length: 391
• Species: Drosophila melanogaster
• Sequence 2: NP_001002802.1
• Gene: Bace2 / 288227
• RGDID: 1303241
• Length: 514
• Species: Rattus norvegicus
• Alignment Length: 361
• Identity: 109/361 - (30%)
• Similarity: 168/361 - (46%)
• Gaps: 53/361 - (14%)

  Fly    66 ENLHNSMNNEYYGVIAIGTPEQRFNILFDTGSANLWVPSASCPASNTACQRHNKYDSSASSTYVA 130
            :||.......||..:.||||.|:..||.||||:|..|..|.....:|      .:||.:||||.:
  Rat    78 DNLQGDSGRGYYLEMLIGTPPQKVRILVDTGSSNFAVAGAPHSYIDT------YFDSESSSTYHS 136

  Fly   131 NGEEFAIEYGTGSLSGFLSNDIVTI-AGISIQNQTFGEALSEPGTTFVDAPF-------AGILGL 187
            .|.|..::|..||.:||:..|:||| .|.   |.:|   |....|.|....|       .|||||
  Rat   137 KGFEVTVKYTQGSWTGFVGEDLVTIPKGF---NSSF---LVNIATIFESENFFLPGIKWNGILGL 195

  Fly   188 AFSAIA--VDGVTPPFDNMISQGLLDEPVISFY-----LKRQGTAVRGGELILGGIDSSLYRGSL 245
            |::|:|  ...:...||::::|..:.: :.|..     |...|:...||.|:||||:.|||:|.:
  Rat   196 AYAALAKPSSSLETFFDSLVAQAKIPD-IFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDI 259

  Fly   246 TYVPVSVPAYWQFKVNTIKTNGTLL---C---NGCQAIADTGTSLIAVPLAAYRKINRQLGATD- 303
            .|.|:....|:|.::..::..|..|   |   |..:||.|:||:|:.:|...:..:...:..|.
  Rat   260 WYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARTSL 324

  Fly   304 ----NDG---EAFVRCGRVSS-----LPKVNL-----NIGGTV-FTLAPRDYIVKVTQNGQTYCM 350
                :||   .|.:.|...|.     .||:::     |...:. .|:.|:.||..:...|..|..
  Rat   325 IPEFSDGFWTGAQLACWTNSETPWAYFPKISIYLRDENASRSFRITILPQLYIQPMMGAGFNYEC 389

  Fly   351 SAFTYMEGLSFWILGDVFIGKFYTVFDKGNERIGFA 386
            ..|......:..::|...:..||.|||:...|:|||
  Rat   390 YRFGISSSTNALVIGATVMEGFYVVFDRAQRRVGFA 425

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG17134	NP_609458.1	pepsin_retropepsin_like	70..386	CDD:472175	105/355 (30%)
Bace2	NP_001002802.1	beta_secretase_like	85..446	CDD:133140	107/354 (30%)