DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG17134 and BACE2

DIOPT Version :9

Sequence 1:NP_609458.1 Gene:CG17134 / 34494 FlyBaseID:FBgn0032304 Length:391 Species:Drosophila melanogaster
Sequence 2:NP_036237.2 Gene:BACE2 / 25825 HGNCID:934 Length:518 Species:Homo sapiens


Alignment Length:446 Identity:123/446 - (27%)
Similarity:191/446 - (42%) Gaps:83/446 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 RQLLVLLVLVGIGHSAAKLN--------RVQLQVNKNFTKTHG-SVKAEKTVLASKYSFLAETSF 57
            |.||:.|:...:..:|.:|.        ||....|:....|.| ...||:.  |...:...|.:.
Human     6 RALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERH--ADGLALALEPAL 68

  Fly    58 SVSSSGA------TENLHNSMNNEYYGVIAIGTPEQRFNILFDTGSANLWVPSASCPASNTACQR 116
            : |.:||      .:||.......||..:.||||.|:..||.||||:|..|  |..|.|..    
Human    69 A-SPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAV--AGTPHSYI---- 126

  Fly   117 HNKYDSSASSTYVANGEEFAIEYGTGSLSGFLSNDIVTI-AGISIQNQTFGEALSEPGTTFVDAP 180
            ...:|:..||||.:.|.:..::|..||.:||:..|:||| .|.   |.:|   |....|.|....
Human   127 DTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGF---NTSF---LVNIATIFESEN 185

  Fly   181 F-------AGILGLAFSAIA--VDGVTPPFDNMISQGLLDEPVISFY-----LKRQGTAVRGGEL 231
            |       .||||||::.:|  ...:...||::::|..:.. |.|..     |...|:...||.|
Human   186 FFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPN-VFSMQMCGAGLPVAGSGTNGGSL 249

  Fly   232 ILGGIDSSLYRGSLTYVPVSVPAYWQFKVNTIKTNGTLL---C---NGCQAIADTGTSLIAVPLA 290
            :||||:.|||:|.:.|.|:....|:|.::..::..|..|   |   |..:||.|:||:|:.:|..
Human   250 VLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQK 314

  Fly   291 AYRKI-------------------NRQLGATDNDGEAFVRCGRVSSLPKVNLNI----GGTVF-- 330
            .:..:                   ..||....|....:      |..||:::.:    ....|  
Human   315 VFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPW------SYFPKISIYLRDENSSRSFRI 373

  Fly   331 TLAPRDYIVKVTQNGQTYCMSAFTYMEGLSFWILGDVFIGKFYTVFDKGNERIGFA 386
            |:.|:.||..:...|..|....|......:..::|...:..||.:||:..:|:|||
Human   374 TILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFA 429

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG17134NP_609458.1 pepsin_retropepsin_like 70..386 CDD:299705 101/361 (28%)
Asp 75..388 CDD:278455 103/358 (29%)
BACE2NP_036237.2 beta_secretase_like 89..450 CDD:133140 103/360 (29%)
Asp 92..430 CDD:278455 103/357 (29%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165151476
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1339
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 1 0.950 - 0 Normalized mean entropy S4148
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
43.690

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