DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG17134 and BACE1

DIOPT Version :10

Sequence 1:NP_609458.1 Gene:CG17134 / 34494 FlyBaseID:FBgn0032304 Length:391 Species:Drosophila melanogaster
Sequence 2:NP_036236.1 Gene:BACE1 / 23621 HGNCID:933 Length:501 Species:Homo sapiens


Alignment Length:361 Identity:105/361 - (29%)
Similarity:166/361 - (45%) Gaps:49/361 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly    66 ENLHNSMNNEYYGVIAIGTPEQRFNILFDTGSANLWVPSASCPASNTACQRHNKYDSSASSTYVA 130
            :||.......||..:.:|:|.|..|||.||||:|..|.:|..|.      .|..|....||||..
Human    65 DNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPF------LHRYYQRQLSSTYRD 123

  Fly   131 NGEEFAIEYGTGSLSGFLSNDIVTIA-GISIQNQTFGEALSEPGTTFVD-APFAGILGLAFSAIA 193
            ..:...:.|..|...|.|..|:|:|. |.::..:....|::|....|:: :.:.||||||::.||
Human   124 LRKGVYVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIA 188

  Fly   194 --VDGVTPPFDNMISQGLLDEPVISFYLKRQG--------TAVRGGELILGGIDSSLYRGSLTYV 248
              .|.:.|.||:::.|..:.. :.|..|...|        .|..||.:|:||||.|||.|||.|.
Human   189 RPDDSLEPFFDSLVKQTHVPN-LFSLQLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYT 252

  Fly   249 PVSVPAYWQFKVNTIKTNGTLLCNGC------QAIADTGTSLIAVPLAAYRKINRQLGATDND-- 305
            |:....|::..:..::.||..|...|      ::|.|:||:.:.:|...:....:.:.|..:.  
Human   253 PIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEK 317

  Fly   306 -------GEAFVRCGRVSS-----LPKVNLNIGGTV------FTLAPRDYI--VKVTQNGQTYCM 350
                   ||..| |.:..:     .|.::|.:.|.|      .|:.|:.|:  |:.....|..|.
Human   318 FPDGFWLGEQLV-CWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCY 381

  Fly   351 SAFTYMEGLSFWILGDVFIGKFYTVFDKGNERIGFA 386
            . |...:..:..::|.|.:..||.|||:..:|||||
Human   382 K-FAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFA 416

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG17134NP_609458.1 pepsin_retropepsin_like 70..386 CDD:472175 101/355 (28%)
BACE1NP_036236.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 39..58
beta_secretase_like 72..437 CDD:133140 103/354 (29%)
Interaction with RTN3 479..501
DXXLL. /evidence=ECO:0000269|PubMed:15886016 496..500
Blue background indicates that the domain is not in the aligned region.

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