DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17134 and Ctsd

DIOPT Version :9

Sequence 1:	NP_609458.1	Gene:	CG17134 / 34494	FlyBaseID:	FBgn0032304	Length:	391	Species:	Drosophila melanogaster
Sequence 2:	NP_034113.1	Gene:	Ctsd / 13033	MGIID:	88562	Length:	410	Species:	Mus musculus

Alignment Length:	407	Identity:	179/407 - (43%)
Similarity:	246/407 - (60%)	Gaps:	33/407 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 VLLVLVG-IGHSAAKLNRVQLQ----VNKNFTKTHGSVKAEKTVLASKYSFLAETSFSVSSSGAT 65
            |||:::| :..|:..:.|:.|:    :.:..|:..|||  |..:|....     |.:|:.||..|
Mouse     6 VLLLILGLLASSSFAIIRIPLRKFTSIRRTMTEVGGSV--EDLILKGPI-----TKYSMQSSPKT 63

  Fly    66 -----ENLHNSMNNEYYGVIAIGTPEQRFNILFDTGSANLWVPSASCPASNTACQRHNKYDSSAS 125
                 |.|.|.::.:|||.|.||||.|.|.::|||||:||||||..|...:.||..|:||:|..|
Mouse    64 TEPVSELLKNYLDAQYYGDIGIGTPPQCFTVVFDTGSSNLWVPSIHCKILDIACWVHHKYNSDKS 128

  Fly   126 STYVANGEEFAIEYGTGSLSGFLSNDIVTI---------AGISIQNQTFGEALSEPGTTFVDAPF 181
            ||||.||..|.|.||:|||||:||.|.|::         .||.::.|.||||..:||..||.|.|
Mouse   129 STYVKNGTSFDIHYGSGSLSGYLSQDTVSVPCKSDQSKARGIKVEKQIFGEATKQPGIVFVAAKF 193

  Fly   182 AGILGLAFSAIAVDGVTPPFDNMISQGLLDEPVISFYLKRQGTAVRGGELILGGIDSSLYRGSLT 246
            .||||:.:..|:|:.|.|.|||::.|.|:|:.:.||||.|......||||:|||.||..|.|.|:
Mouse   194 DGILGMGYPHISVNNVLPVFDNLMQQKLVDKNIFSFYLNRDPEGQPGGELMLGGTDSKYYHGELS 258

  Fly   247 YVPVSVPAYWQFKVNTIKTNGTL-LC-NGCQAIADTGTSLIAVPLAAYRKINRQLGATD-NDGEA 308
            |:.|:..||||..::.::....| || .||:||.||||||:..|:...:::.:.:||.. ..||.
Mouse   259 YLNVTRKAYWQVHMDQLEVGNELTLCKGGCEAIVDTGTSLLVGPVEEVKELQKAIGAVPLIQGEY 323

  Fly   309 FVRCGRVSSLPKVNLNIGGTVFTLAPRDYIVKVTQNGQTYCMSAFTYME----GLSFWILGDVFI 369
            .:.|.:|||||.|.|.:||..:.|.|..||:||:|.|:|.|:|.|..|:    ....||||||||
Mouse   324 MIPCEKVSSLPTVYLKLGGKNYELHPDKYILKVSQGGKTICLSGFMGMDIPPPSGPLWILGDVFI 388

  Fly   370 GKFYTVFDKGNERIGFA 386
            |.:|||||:.|.|:|||
Mouse   389 GSYYTVFDRDNNRVGFA 405

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17134	NP_609458.1	pepsin_retropepsin_like	70..386	CDD:299705	157/331 (47%)
CG17134	NP_609458.1	Asp	75..388	CDD:278455	158/328 (48%)
Ctsd	NP_034113.1	A1_Propeptide	21..46	CDD:285240	7/26 (27%)
		Cathepsin_D2	73..405	CDD:133157	157/331 (47%)
		Asp	78..407	CDD:278455	158/328 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1339
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54317
OrthoDB	1	1.010	-	-		D1619495at2759
OrthoFinder	1	1.000	-	-		FOG0000066
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR47966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	7	6.890