Protein Alignment CG17134 and bace2

DIOPT Version :10

• Sequence 1: NP_609458.1
• Gene: CG17134 / 34494
• FlyBaseID: FBgn0032304
• Length: 391
• Species: Drosophila melanogaster
• Sequence 2: NP_001135590.1
• Gene: bace2 / 100216145
• XenbaseID: XB-GENE-1014090
• Length: 499
• Species: Xenopus tropicalis
• Alignment Length: 443
• Identity: 118/443 - (26%)
• Similarity: 190/443 - (42%)
• Gaps: 98/443 - (22%)

  Fly     7 LLVLVGIGHSAAKLNRV-QLQVNKNFTKTHGSVK-AEKTVLASKYSFLAETSFSVSSSGATENLH 69
            ||.::.:|.:.|..|.: .|:|:.  .:..|:|. |..|...:....||      |..|...|..
 Frog     5 LLAVLLLGAACASANFIFPLKVSP--AEMKGAVPVAPATPKGAPGLLLA------SDPGGQINFF 61

  Fly    70 NSMNN-------EYYGVIAIGTPEQRFNILFDTGSANLWVPSASCPASNTACQRHNKYDSSASST 127
            :.:||       .||..:.||||.|:.|||.||||:|..|..|..|...|.      :||..|::
 Frog    62 SMVNNLEGDSGRGYYLELLIGTPPQKMNILVDTGSSNFAVAGALNPDITTF------FDSKLSTS 120

  Fly   128 YVANGEEFAIEYGTGSLSGFLSNDIVTI-AGISIQNQTFGEALSEPGTTFVDAPF-------AGI 184
            |.....:..:.|..||.:|.|..|:::: .|:   |.||   |....:.|....|       .||
 Frog   121 YEPLNTQVTVRYTQGSWTGLLGKDVISMPKGV---NGTF---LINIASIFQSENFFLPNINWQGI 179

  Fly   185 LGLAFSAIA--VDGVTPPFDNMISQGLLDEPVISFYLKRQ--------GTAVRGGELILGGIDSS 239
            ||||:|.:|  ...|.|.||:::.|    |.:.:.:..:.        |..:..|.|:||||:.|
 Frog   180 LGLAYSTLAKPSSSVEPFFDSLVQQ----ENIPNIFSMQMCGAGQPSPGIGINAGSLVLGGIEPS 240

  Fly   240 LYRGSLTYVPVSVPAYWQFKVNTIKTNG---TLLC---NGCQAIADTGTSLIAVPLAAYRKI--- 295
            ||:|.:.|.|::...|:|.:|...:..|   .|.|   |..:||.|:||:|:.:|...:..:
 Frog   241 LYQGDIWYTPITEEWYYQVEVLKFEVGGQNLNLDCTVYNSDKAIVDSGTTLLRLPDKVFNAMVDA 305

  Fly   296 ----------------NRQLGATDNDGEAFVRCGRVSSLPKVNLNIGGTVFTLAPRDYIVKVTQN 344
                            ..||...|...:.:      :..|.:::.:..   |.:.|.:  ::|..
 Frog   306 IVQTSLIQNFNAEFWAGLQLACWDKTQDPW------NYFPDISIYLRD---TNSSRSF--RLTLK 359

  Fly   345 GQTYCMSAFTYMEGL-----------SFWILGDVFIGKFYTVFDKGNERIGFA 386
            .|.|..|..|:.|.|           |..::|...:..||.:||:..:|:|||
 Frog   360 PQLYIQSVLTFQESLNCFRFGISQSASALVIGATVMEGFYVIFDRAEKRVGFA 412

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG17134	NP_609458.1	pepsin_retropepsin_like	70..386	CDD:472175	100/376 (27%)
bace2	NP_001135590.1	beta_secretase_like	72..433	CDD:133140	100/368 (27%)