Protein Alignment CG6508 and NAPSA

DIOPT Version :9

• Sequence 1: NP_609457.1
• Gene: CG6508 / 34493
• FlyBaseID: FBgn0032303
• Length: 423
• Species: Drosophila melanogaster
• Sequence 2: NP_004842.1
• Gene: NAPSA / 9476
• HGNCID: 13395
• Length: 420
• Species: Homo sapiens
• Alignment Length: 408
• Identity: 154/408 - (37%)
• Similarity: 215/408 - (52%)
• Gaps: 37/408 - (9%)

  Fly     7 IIIPLFLLL----LDHSMGQLRRTPITRQINQNKTHANV------KAEKILLAA-----KYFLVD 56
            ::.||.|||    ::.|...|.|.|:.| :...:...|:      .||...|.|     |...|.
Human     6 LLQPLLLLLPLLNVEPSGATLIRIPLHR-VQPGRRILNLLRGWREPAELPKLGAPSPGDKPIFVP 69

  Fly    57 RQSSQTTQVLANGFNLEYTIRLCIGTPPQCFNLQFDTGSSDLWVPSVKCSSTNEACQKHNKYNSS 121
                     |:|..:::|...:.:|||||.|.:.||||||:|||||.:|...:..|..|::::..
Human    70 ---------LSNYRDVQYFGEIGLGTPPQNFTVAFDTGSSNLWVPSRRCHFFSVPCWLHHRFDPK 125

  Fly   122 ASSSHVEDGKGFSIQYGSGSLSGFLSTDTVDIDGMVIRNQTFAEAIDEPGSAFVNTIFDGIIGMA 186
            ||||...:|..|:||||:|.:.|.||.|.:.|.|:...:..|.||:.||...|....||||:|:.
Human   126 ASSSFQANGTKFAIQYGTGRVDGILSEDKLTIGGIKGASVIFGEALWEPSLVFAFAHFDGILGLG 190

  Fly   187 FASIS-GGVTTPFDNIIRQGLVKHPVFSVYLRRDGTSQSGGEVIWGGIDRSIYRGCINYVPVSMP 250
            |..:| .||..|.|.::.|||:..||||.||.||.....|||::.||.|.:.|...:.:|||::|
Human   191 FPILSVEGVRPPMDVLVEQGLLDKPVFSFYLNRDPEEPDGGELVLGGSDPAHYIPPLTFVPVTVP 255

  Fly   251 AYWQFTANSVKI-EGILLC-NGCQAIADTGTSLIAVPLRAYKAINKVLNATDAGDGEAFVDCSSL 313
            ||||.....||: .|:.|| .||.||.|||||||..|....:|::..:.......||..:.||.:
Human   256 AYWQIHMERVKVGPGLTLCAKGCAAILDTGTSLITGPTEEIRALHAAIGGIPLLAGEYIILCSEI 320

  Fly   314 CRLPNVNLNIGGTTYTLTPKDYIYKVQADNNQTLCLSGFTYLQ----GNLLWILGDIFLGKVYTV 374
            .:||.|:..:||..:.||..||:.:. ..|...||||||..|.    ....|||||:|||....|
Human   321 PKLPAVSFLLGGVWFNLTAHDYVIQT-TRNGVRLCLSGFQALDVPPPAGPFWILGDVFLGTYVAV 384

  Fly   375 FDVG----KERIGFAKLK 388
            ||.|    ..|:|.|:.:
Human   385 FDRGDMKSSARVGLARAR 402

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG6508	NP_609457.1	pepsin_retropepsin_like	68..386	CDD:299705	135/328 (41%)
		Asp	73..387	CDD:278455	135/324 (42%)
NAPSA	NP_004842.1	pepsin_retropepsin_like	72..399	CDD:299705	135/327 (41%)
		Asp	77..401	CDD:278455	135/324 (42%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151470
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1339
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54317
OrthoDB	1	1.010	-	-		D1619495at2759
OrthoFinder	1	1.000	-	-		FOG0000066
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR47966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	8	7.820