DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6508 and YPS7

DIOPT Version :9

Sequence 1:	NP_609457.1	Gene:	CG6508 / 34493	FlyBaseID:	FBgn0032303	Length:	423	Species:	Drosophila melanogaster
Sequence 2:	NP_010636.1	Gene:	YPS7 / 851950	SGDID:	S000002757	Length:	596	Species:	Saccharomyces cerevisiae

Alignment Length:	468	Identity:	102/468 - (21%)
Similarity:	175/468 - (37%)	Gaps:	145/468 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    59 SSQTTQ---VLANGFN--LEYTIRLCIGTPPQCFNLQFDTGSSDLWVPSVKCSSTNE---ACQKH 115
            ||.|.:   |||.|.:  ..|.:....|||.|...|..|.....:.:.|....|.||   ...||
Yeast    36 SSSTEEPFPVLAVGKDGRGNYYVNSTFGTPGQRQRLLVDIIQPYINLVSGTSESHNEYSGVYHKH 100

  Fly   116 NKY--NSSASSSHVEDGKGFSIQYGSG-SLSGFLSTDTVDIDGMVIRNQTFAEAID--------- 168
            ..|  |.|.||..|..|:.:.|.:..| :::..|.||.::...:...|.:.|...|
Yeast   101 PSYLMNDSTSSVPVSPGQIYEISFIDGRAVNCTLVTDDMNFTNVSSENSSTALITDLMVTRDNVQ 165

  Fly   169 -EPGSAFVNTI--FD---------GIIGMAFASISGGVTTP--------------FDNIIRQG-L 206
             ..||..::.:  ||         |::|     :||.||.|              |.::::.. :
Yeast   166 FNSGSLSISNVSFFDIQSSNFKTSGLLG-----LSGKVTNPGNAIDSSQYTEQSYFLSLLKDADI 225

  Fly   207 VKHPVFSVYLRRDGTS--------QSGGEVIWGGIDRSIYRG------CINYV-PVSMPAYWQFT 256
            ::...:|::|..|.::        .:.|:::.||:|.|::.|      .|.|| |||
Yeast   226 IESSSYSLWLAGDTSTYKTYRDPISNCGKLLLGGVDPSLFTGTLGKFDLIPYVDPVS-------- 282

  Fly   257 ANSVKIEG---------ILLCNGCQ------------AIADTGTSLIAVPLRAYKAINKVLNATD 300
             |:|.: |         .::.|..|            |:.|:.:|:..:|......|...:.||
Yeast   283 -NAVSV-GYPIVPLGPIYIVSNSGQSLNMTSKDFLSPALLDSTSSVSYLPTSTIIQIAVQIAAT- 344

  Fly   301 AGDGEAFVDCSSL------CRLPNVNLNIG----------------GTTYTLTPKDYIYKVQADN 343
                  :|:  ||      |.:.::.:::|                .:||..:....::   ..:
Yeast   345 ------YVE--SLDRWLVQCSIADMGVSLGFRLRELTIEIPLRDLLSSTYDTSTNSSMF---FSS 398

  Fly   344 NQTLCLSGFTYLQGNL---LWILGDIFLGKVYTVFDVGKERIGFAKLKK-------HSSYRVYAS 398
            .|..|   |..|..|.   :.|||:.|:..:|...|:....|..|:.||       ..:....||
Yeast   399 GQEAC---FLTLYANTNTGVNILGEAFIKNIYMAMDLEDNTIAIAQAKKVEDDAVTEETNETTAS 460

  Fly   399 SYVKEPSSYGIDY 411
            :.:|:..|..|.|
Yeast   461 TIIKKIKSGYIPY 473

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6508	NP_609457.1	pepsin_retropepsin_like	68..386	CDD:299705	87/422 (21%)
CG6508	NP_609457.1	Asp	73..387	CDD:278455	87/416 (21%)
YPS7	NP_010636.1	pepsin_retropepsin_like	162..442	CDD:416259	59/309 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1339
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000066
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810