Protein Alignment CG6508 and PGA4

DIOPT Version :9

• Sequence 1: NP_609457.1
• Gene: CG6508 / 34493
• FlyBaseID: FBgn0032303
• Length: 423
• Species: Drosophila melanogaster
• Sequence 2: NP_001073276.1
• Gene: PGA4 / 643847
• HGNCID: 8886
• Length: 388
• Species: Homo sapiens
• Alignment Length: 385
• Identity: 160/385 - (41%)
• Similarity: 217/385 - (56%)
• Gaps: 42/385 - (10%)

  Fly    25 RTPITRQINQNKTHAN-------VKAEKILLAAKYF-------LVDRQSSQTTQVLANGFNLEYT 75
            :.|:.|:.:..:|.:.       :|...:..|.|||       |||.|.      |.|..::||.
Human    19 KVPLIRKKSLRRTLSERGLLKDFLKKHNLNPARKYFPQWEAPTLVDEQP------LENYLDMEYF 77

  Fly    76 IRLCIGTPPQCFNLQFDTGSSDLWVPSVKCSSTNEACQKHNKYNSSASSSHVEDGKGFSIQYGSG 140
            ..:.||||.|.|.:.||||||:||||||.|||.  ||..||::|...||::....:..||.||:|
Human    78 GTIGIGTPAQDFTVVFDTGSSNLWVPSVYCSSL--ACTNHNRFNPEDSSTYQSTSETVSITYGTG 140

  Fly   141 SLSGFLSTDTVDIDGMVIRNQTFAEAIDEPGSAFVNTIFDGIIGMAFASISGGVTTP-FDNIIRQ 204
            |::|.|..|||.:.|:...||.|..:..||||......||||:|:|:.|||....|| ||||..|
Human   141 SMTGILGYDTVQVGGISDTNQIFGLSETEPGSFLYYAPFDGILGLAYPSISSSGATPVFDNIWNQ 205

  Fly   205 GLVKHPVFSVYLRRDGTSQSGGEVIWGGIDRSIYRGCINYVPVSMPAYWQFTANSVKIEG--ILL 267
            |||...:|||||..|  .|||..||:||||.|.|.|.:|:|||::..|||.|.:|:.:.|  |..
Human   206 GLVSQDLFSVYLSAD--DQSGSVVIFGGIDSSYYTGSLNWVPVTVEGYWQITVDSITMNGEAIAC 268

  Fly   268 CNGCQAIADTGTSLIAVPLRAYKAINKVLNATDAGDGEAFVDCSSLCRLPNVNLNIGGTTYTLTP 332
            ..|||||.||||||:..|......|...:.|::..||:..|.||::..||::...|.|..|.:.|
Human   269 AEGCQAIVDTGTSLLTGPTSPIANIQSDIGASENSDGDMVVSCSAISSLPDIVFTINGVQYPVPP 333

  Fly   333 KDYIYKVQADNNQTLCLSGFTYLQG-NL------LWILGDIFLGKVYTVFDVGKERIGFA 385
            ..||  :|::.:   |:|||   || ||      ||||||:|:.:.:||||....::|.|
Human   334 SAYI--LQSEGS---CISGF---QGMNLPTESGELWILGDVFIRQYFTVFDRANNQVGLA 385

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG6508	NP_609457.1	pepsin_retropepsin_like	68..386	CDD:299705	147/328 (45%)
		Asp	73..387	CDD:278455	146/323 (45%)
PGA4	NP_001073276.1	A1_Propeptide	17..45	CDD:311771	4/25 (16%)
		pepsin_A	66..386	CDD:133145	149/338 (44%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151457
Domainoid	1	1.000	297	1.000	Domainoid score	I1463
eggNOG	1	0.900	-	-		E1_KOG1339
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	319	1.000	Inparanoid score	I2536
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54317
OrthoDB	1	1.010	-	-		D1619495at2759
OrthoFinder	1	1.000	-	-		FOG0000066
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR47966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1456
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	10	9.910