Protein Alignment CG6508 and PGC

DIOPT Version :10

• Sequence 1: NP_609457.1
• Gene: CG6508 / 34493
• FlyBaseID: FBgn0032303
• Length: 423
• Species: Drosophila melanogaster
• Sequence 2: NP_002621.1
• Gene: PGC / 5225
• HGNCID: 8890
• Length: 388
• Species: Homo sapiens
• Alignment Length: 405
• Identity: 154/405 - (38%)
• Similarity: 226/405 - (55%)
• Gaps: 48/405 - (11%)

  Fly     6 LIIIPLFLLLLDHSMGQLRRTPITRQINQNKTHANVKAEKILL-----------AAKYFLVDRQS 59
            ::::.:.|.||:.::       :...:.:.|:......||.||           |.||...|  .
Human     4 MVVVLVCLQLLEAAV-------VKVPLKKFKSIRETMKEKGLLGEFLRTHKYDPAWKYRFGD--L 59

  Fly    60 SQTTQVLANGFNLEYTIRLCIGTPPQCFNLQFDTGSSDLWVPSVKCSSTNEACQKHNKYNSSASS 124
            |.|.:.:|. .:..|...:.||||||.|.:.||||||:||||||.|.|  :||..|:::|.|.||
Human    60 SVTYEPMAY-MDAAYFGEISIGTPPQNFLVLFDTGSSNLWVPSVYCQS--QACTSHSRFNPSESS 121

  Fly   125 SHVEDGKGFSIQYGSGSLSGFLSTDTVDIDGMVIRNQTFAEAIDEPGSAFVNTIFDGIIGMAFAS 189
            ::..:|:.||:|||||||:||...||:.:..:.:.||.|..:.:|||:.||...||||:|:|:.:
Human   122 TYSTNGQTFSLQYGSGSLTGFFGYDTLTVQSIQVPNQEFGLSENEPGTNFVYAQFDGIMGLAYPA 186

  Fly   190 IS-GGVTTPFDNIIRQGLVKHPVFSVYLRRDGTSQSGGEVIWGGIDRSIYRGCINYVPVSMPAYW 253
            :| ...||....::::|.:..|||||||.....| |||.|::||:|.|:|.|.|.:.||:...||
Human   187 LSVDEATTAMQGMVQEGALTSPVFSVYLSNQQGS-SGGAVVFGGVDSSLYTGQIYWAPVTQELYW 250

  Fly   254 QFTANSVKIEGILL-------CN-GCQAIADTGTSLIAVPLRAYKAINKVLNATDAGDGEAFVDC 310
            |     :.||..|:       |: |||||.||||||:.||.:...|:.:...|.:...|:..|:|
Human   251 Q-----IGIEEFLIGGQASGWCSEGCQAIVDTGTSLLTVPQQYMSALLQATGAQEDEYGQFLVNC 310

  Fly   311 SSLCRLPNVNLNIGGTTYTLTPKDYIYKVQADNNQTLCLSGF--TYL---QGNLLWILGDIFLGK 370
            :|:..||::...|.|..:.|.|..||.     :|...|..|.  |||   .|..||||||:||..
Human   311 NSIQNLPSLTFIINGVEFPLPPSSYIL-----SNNGYCTVGVEPTYLSSQNGQPLWILGDVFLRS 370

  Fly   371 VYTVFDVGKERIGFA 385
            .|:|:|:|..|:|||
Human   371 YYSVYDLGNNRVGFA 385

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG6508	NP_609457.1	pepsin_retropepsin_like	68..386	CDD:472175	139/332 (42%)
PGC	NP_002621.1	A1_Propeptide	20..46	CDD:462326	5/25 (20%)
		gastricsin	70..387	CDD:133144	139/329 (42%)