DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6508 and ctsd

DIOPT Version :9

Sequence 1:	NP_609457.1	Gene:	CG6508 / 34493	FlyBaseID:	FBgn0032303	Length:	423	Species:	Drosophila melanogaster
Sequence 2:	NP_988964.1	Gene:	ctsd / 394561	XenbaseID:	XB-GENE-5906945	Length:	398	Species:	Xenopus tropicalis

Alignment Length:	396	Identity:	163/396 - (41%)
Similarity:	232/396 - (58%)	Gaps:	21/396 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MEVG-QLIIIPLFLLLLDHSMGQLRRTPITRQINQNKTHANVKAEKILLAAKYFLVDRQSSQTTQ 64
            |:.| .|:.|||           .:.|.|.|.:::....| :|......|.||.......:.|.:
Frog    16 MQPGSSLVRIPL-----------KKFTSIRRAMSETDQDA-LKLSGNEAATKYSAFLNSKNPTPE 68

  Fly    65 VLANGFNLEYTIRLCIGTPPQCFNLQFDTGSSDLWVPSVKCSSTNEACQKHNKYNSSASSSHVED 129
            .|.|..:.:|...:.||||||.|.:.||||||:|||||:.||..:.||..|:||:||.|::::.:
Frog    69 TLLNYLDAQYYGEIGIGTPPQPFTVVFDTGSSNLWVPSIHCSFWDLACWLHHKYDSSKSTTYINN 133

  Fly   130 GKGFSIQYGSGSLSGFLSTDTVDIDGMVIRNQTFAEAIDEPGSAFVNTIFDGIIGMAFASIS-GG 193
            |..|:||||||||:|:||.|||.|..:.:..|.|||||.:||..||...||||:||.:..|| .|
Frog   134 GTEFAIQYGSGSLTGYLSKDTVTIGDLAVNGQFFAEAIKQPGITFVAAKFDGILGMGYPKISVDG 198

  Fly   194 VTTPFDNIIRQGLVKHPVFSVYLRRDGTSQSGGEVIWGGIDRSIYRGCINYVPVSMPAYWQFTAN 258
            |...||:|:.|.||...:||.||.|:..:..|||::.||.|.:.|.|..||:.|:..||||...:
Frog   199 VPPVFDDIMEQKLVDSNIFSFYLNRNPDTLPGGELLLGGTDPAFYTGDFNYMNVTRKAYWQIHMD 263

  Fly   259 SVKI-EGILLC-NGCQAIADTGTSLIAVPLRAYKAINKVLNATDAGDGEAFVDCSSLCRLPNVNL 321
            .:.: :.:.|| :||:||.|||||||..|:....|:.:.:.|.....||..:.|.|:..||.::.
Frog   264 QLSVGDRLSLCKDGCEAIVDTGTSLITGPVEEVTALQRAIGAIPLICGEYMILCDSIPSLPVISF 328

  Fly   322 NIGGTTYTLTPKDYIYKVQADNNQTLCLSGFTYLQ----GNLLWILGDIFLGKVYTVFDVGKERI 382
            ..||..|:||.:.|:.|: :...:|:|||||..|.    ...|||:||:|:|:.|||||...:|:
Frog   329 TFGGRAYSLTGEQYVLKI-SKAGRTVCLSGFLGLDIPPPAGPLWIIGDVFIGQYYTVFDRANDRV 392

  Fly   383 GFAKLK 388
            ||||.|
Frog   393 GFAKAK 398

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6508	NP_609457.1	pepsin_retropepsin_like	68..386	CDD:299705	144/324 (44%)
CG6508	NP_609457.1	Asp	73..387	CDD:278455	144/320 (45%)
ctsd	NP_988964.1	A1_Propeptide	22..>39	CDD:311771	7/27 (26%)
ctsd	NP_988964.1	pepsin_retropepsin_like	72..396	CDD:325019	144/324 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1619495at2759
OrthoFinder	1	1.000	-	-		FOG0000066
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR47966
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	4.110