DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6508 and CG10104

DIOPT Version :9

Sequence 1:	NP_609457.1	Gene:	CG6508 / 34493	FlyBaseID:	FBgn0032303	Length:	423	Species:	Drosophila melanogaster
Sequence 2:	NP_610961.1	Gene:	CG10104 / 36602	FlyBaseID:	FBgn0033933	Length:	404	Species:	Drosophila melanogaster

Alignment Length:	396	Identity:	158/396 - (39%)
Similarity:	226/396 - (57%)	Gaps:	20/396 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 IIPLFLLL---LDHSMG---QLRRTPITR--QINQNKTHANVKAEKILL----AAKYFLVDRQSS 60
            ::|:..:|   ..|.:.   ||.|.|:.|  ..........::.:::.|    ...:|..:..|:
  Fly     7 LLPVLFILPVQFQHPVSCKLQLYRVPLRRFPSARHRFEKLGIRMDRLRLKYAEEVSHFRGEWNSA 71

  Fly    61 QTTQVLANGFNLEYTIRLCIGTPPQCFNLQFDTGSSDLWVPSVKCSSTNEACQKHNKYNSSASSS 125
            ..:..|:|..:.:|...:.||||||.|.:.||||||:|||||..|:||..||:.||:|.:..|:|
  Fly    72 VKSTPLSNYLDAQYFGPITIGTPPQTFKVIFDTGSSNLWVPSATCASTMVACRVHNRYFAKRSTS 136

  Fly   126 HVEDGKGFSIQYGSGSLSGFLSTDTVDIDGMVIRNQTFAEAIDEPGSAFVNTIFDGIIGMAFASI 190
            |...|..|:|.|||||||||||||||.:.|:.||:||||||.:.||..|:...||||.|:|:.||
  Fly   137 HQVRGDHFAIHYGSGSLSGFLSTDTVRVAGLEIRDQTFAEATEMPGPIFLAAKFDGIFGLAYRSI 201

  Fly   191 S-GGVTTPFDNIIRQGLVKHPVFSVYLRRDGTSQSGGEVIWGGIDRSIYRGCINYVPVSMPAYWQ 254
            | ..:..||..::.|||:..|:|||||.|:| .:.||.:.:||.:...|.|...||.||..||||
  Fly   202 SMQRIKPPFYAMMEQGLLTKPIFSVYLSRNG-EKDGGAIFFGGSNPHYYTGNFTYVQVSHRAYWQ 265

  Fly   255 FTANSVKIEGILLC-NGCQAIADTGTSLIAVPLRAYKAINKVLNATDAGDGEAFVDCSSLCRLPN 318
            ...:|..|..:.|| .||:.|.|||||.:|:|......||:.:..|.:..|:..|.|.|:..||.
  Fly   266 VKMDSAVIRNLELCQQGCEVIIDTGTSFLALPYDQAILINESIGGTPSSFGQFLVPCDSVPDLPK 330

  Fly   319 VNLNIGGTTYTLTPKDYIYKVQADNNQTLCLSGFTYLQ----GNLLWILGDIFLGKVYTVFDVGK 379
            :...:||..:.|...:|::: ....::.:|.|.|..:.    ...||||||:||||.||.||:.:
  Fly   331 ITFTLGGRRFFLESHEYVFR-DIYQDRRICSSAFIAVDLPSPSGPLWILGDVFLGKYYTEFDMER 394

  Fly   380 ERIGFA 385
            .|||||
  Fly   395 HRIGFA 400

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6508	NP_609457.1	pepsin_retropepsin_like	68..386	CDD:299705	146/324 (45%)
CG6508	NP_609457.1	Asp	73..387	CDD:278455	145/319 (45%)
CG10104	NP_610961.1	A1_Propeptide	28..54	CDD:285240	4/25 (16%)
		pepsin_retropepsin_like	76..400	CDD:299705	145/325 (45%)
		Asp	84..402	CDD:278455	145/319 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45455556
Domainoid	1	1.000	97	1.000	Domainoid score	I1884
eggNOG	1	0.900	-	-		E1_KOG1339
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	97	1.000	Inparanoid score	I1684
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1619495at2759
OrthoFinder	1	1.000	-	-		FOG0000066
OrthoInspector	1	1.000	-	-		mtm978
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR47966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	9	8.900