DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6508 and napsa

DIOPT Version :9

Sequence 1:	NP_609457.1	Gene:	CG6508 / 34493	FlyBaseID:	FBgn0032303	Length:	423	Species:	Drosophila melanogaster
Sequence 2:	NP_956325.1	Gene:	napsa / 336746	ZFINID:	ZDB-GENE-030131-8690	Length:	412	Species:	Danio rerio

Alignment Length:	406	Identity:	162/406 - (39%)
Similarity:	238/406 - (58%)	Gaps:	37/406 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LIIIPLFLLLLDHSMGQLRR--TPITRQINQNKTHANVKAEKILLAAKYF--------LVDRQSS 60
            :|.|||      |.|..:||  ....:.|::.|:.|.:|       |||.        .|...:.
Zfish    21 IIRIPL------HKMRTVRRMLADNGKTIDEIKSLAKMK-------AKYSDGTFTNQGSVTIPAP 72

  Fly    61 QTTQV------LANGFNLEYTIRLCIGTPPQCFNLQFDTGSSDLWVPSVKCSSTNEACQKHNKYN 119
            .|||:      |.|..:.:|...:.||||||.|::.||||||:|||||:.|:..:.||..|.:||
Zfish    73 TTTQLPPPVEKLTNFMDAQYYGMISIGTPPQDFSVLFDTGSSNLWVPSIHCAFLDIACWLHRRYN 137

  Fly   120 SSASSSHVEDGKGFSIQYGSGSLSGFLSTDTVDIDGMVIRNQTFAEAIDEPGSAFVNTIFDGIIG 184
            |..||::|::|..||||||.||||||:|.|||::.|:.:..|.||||:.:||..|....|||::|
Zfish   138 SKKSSTYVQNGTEFSIQYGRGSLSGFISQDTVNLAGLNVTGQQFAEAVKQPGIVFAVARFDGVLG 202

  Fly   185 MAFASISGGVTTP-FDNIIRQGLVKHPVFSVYLRRDGTSQSGGEVIWGGIDRSIYRGCINYVPVS 248
            ||:.:||....|| ||..:...::...:||.|:.||.....|||::.||.|:..:.|.::||.|:
Zfish   203 MAYPAISVDRVTPVFDTAMAAKILPQNIFSFYINRDPAGDVGGELMLGGFDQQYFNGDLHYVNVT 267

  Fly   249 MPAYWQFTANSVKIEGIL-LC-NGCQAIADTGTSLIAVPLRAYKAINKVLNATDAGDGEAFVDCS 311
            ..||||...:.|::...| || :|||||.|||||:|..|::..:|:.|.:.|.....||.::||.
Zfish   268 RKAYWQIKMDEVQVGSTLTLCKSGCQAIVDTGTSMITGPVQEVRALQKAIGAIPLLMGEYWIDCK 332

  Fly   312 SLCRLPNVNLNIGGTTYTLTPKDYIYKVQADNNQTLCLSGFTYLQ----GNLLWILGDIFLGKVY 372
            .:..||.|:.::||..:.||.::|:.|: :.....:|||||..:.    ...||||||:|:|:.|
Zfish   333 KIPTLPVVSFSLGGKMFNLTGQEYVMKM-SHMGMNVCLSGFMAMDIPPPAGPLWILGDVFIGRYY 396

  Fly   373 TVFDVGKERIGFAKLK 388
            ||||..::|:|||..|
Zfish   397 TVFDRDQDRVGFAPAK 412

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6508	NP_609457.1	pepsin_retropepsin_like	68..386	CDD:299705	140/324 (43%)
CG6508	NP_609457.1	Asp	73..387	CDD:278455	140/320 (44%)
napsa	NP_956325.1	A1_Propeptide	21..48	CDD:285240	9/32 (28%)
		Cathepsin_D2	86..410	CDD:133157	140/324 (43%)
		Asp	91..411	CDD:278455	140/320 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170585936
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1339
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54317
OrthoDB	1	1.010	-	-		D1619495at2759
OrthoFinder	1	1.000	-	-		FOG0000066
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR47966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	8	7.820