Protein Alignment CG6508 and Bace2

DIOPT Version :9

• Sequence 1: NP_609457.1
• Gene: CG6508 / 34493
• FlyBaseID: FBgn0032303
• Length: 423
• Species: Drosophila melanogaster
• Sequence 2: NP_001002802.1
• Gene: Bace2 / 288227
• RGDID: 1303241
• Length: 514
• Species: Rattus norvegicus
• Alignment Length: 443
• Identity: 114/443 - (25%)
• Similarity: 196/443 - (44%)
• Gaps: 89/443 - (20%)

  Fly     7 IIIPLFLLLLDHSMGQLRRTPITRQIN----QNKTHANV---------KAEKILLAAKYFLVDRQ 58
            :::||....|..::..|...|.|..:.    .|...:.|         :|:.:.||.:      .
  Rat     8 LLLPLLAQWLLRAVPVLAPAPFTLPLQVAGAANHRASTVPGLGTPELPRADGLALALE------P 66

  Fly    59 SSQTTQVLANGFNLE------YTIRLCIGTPPQCFNLQFDTGSSDLWVPSVKCSSTNEACQKHNK 117
            :..|...||...||:      |.:.:.||||||...:..|||||:..|.....|..:      ..
  Rat    67 ARATANFLAMVDNLQGDSGRGYYLEMLIGTPPQKVRILVDTGSSNFAVAGAPHSYID------TY 125

  Fly   118 YNSSASSSHVEDGKGFSIQYGSGSLSGFLSTDTVDI-DGMVIRNQTF---AEAIDEPGSAFVNTI 178
            ::|.:||::...|...:::|..||.:||:..|.|.| .|.   |.:|   ...|.|..:.|:..|
  Rat   126 FDSESSSTYHSKGFEVTVKYTQGSWTGFVGEDLVTIPKGF---NSSFLVNIATIFESENFFLPGI 187

  Fly   179 -FDGIIGMAFASI---SGGVTTPFDNIIRQGLVKHPVFSVY-----LRRDGTSQSGGEVIWGGID 234
             ::||:|:|:|::   |..:.|.||:::.|..:. .:||:.     |...|:..:||.::.|||:
  Rat   188 KWNGILGLAYAALAKPSSSLETFFDSLVAQAKIP-DIFSMQMCGAGLPVAGSGTNGGSLVLGGIE 251

  Fly   235 RSIYRGCINYVPVSMPAYWQFTANSVKIEGILL---C---NGCQAIADTGTSLIAVPLRAYKAIN 293
            .|:|:|.|.|.|:....|:|.....::|.|..|   |   |..:||.|:||:|:.:|.:.:.|:.
  Rat   252 PSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVV 316

  Fly   294 KVLNAT----DAGDG---EAFVDC-----SSLCRLPNVNLNIGGTT------YTLTPKDYIYKVQ 340
            :.:..|    :..||   .|.:.|     :.....|.:::.:....      .|:.|:.||
  Rat   317 EAVARTSLIPEFSDGFWTGAQLACWTNSETPWAYFPKISIYLRDENASRSFRITILPQLYI---- 377

  Fly   341 ADNNQTLCLSGFTY--------LQGNLLWILGDIFLGKVYTVFDVGKERIGFA 385
                |.:..:||.|        ...|.| ::|...:...|.|||..:.|:|||
  Rat   378 ----QPMMGAGFNYECYRFGISSSTNAL-VIGATVMEGFYVVFDRAQRRVGFA 425

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG6508	NP_609457.1	pepsin_retropepsin_like	68..386	CDD:299705	100/369 (27%)
		Asp	73..387	CDD:278455	98/364 (27%)
Bace2	NP_001002802.1	beta_secretase_like	85..446	CDD:133140	98/360 (27%)
		Asp	88..425	CDD:278455	96/355 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166344970
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1339
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.740