Protein Alignment CG6508 and BACE2

DIOPT Version :9

• Sequence 1: NP_609457.1
• Gene: CG6508 / 34493
• FlyBaseID: FBgn0032303
• Length: 423
• Species: Drosophila melanogaster
• Sequence 2: NP_036237.2
• Gene: BACE2 / 25825
• HGNCID: 934
• Length: 518
• Species: Homo sapiens
• Alignment Length: 447
• Identity: 117/447 - (26%)
• Similarity: 199/447 - (44%)
• Gaps: 85/447 - (19%)

  Fly     3 VGQLIIIPLFLLLLDHSMGQLRRTPITRQIN----QNK---------THANVKAEKILLAAKYFL 54
            :.:.:::||....|..:..:|...|.|..:.    .|:         |.|...|:.:.||.:..|
Human     4 LARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPAL 68

  Fly    55 VDRQSSQTTQVLANGFNLE------YTIRLCIGTPPQCFNLQFDTGSSDLWVPSVKCSSTNEACQ 113
            .  ..:.....||...||:      |.:.:.||||||...:..|||||:..|.....|..:
Human    69 A--SPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYID---- 127

  Fly   114 KHNKYNSSASSSHVEDGKGFSIQYGSGSLSGFLSTDTVDI-DGMVIRNQTF---AEAIDEPGSAF 174
              ..:::..||::...|...:::|..||.:||:..|.|.| .|.   |.:|   ...|.|..:.|
Human   128 --TYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGF---NTSFLVNIATIFESENFF 187

  Fly   175 VNTI-FDGIIGMAFASI---SGGVTTPFDNIIRQGLVKHPVFSVY-----LRRDGTSQSGGEVIW 230
            :..| ::||:|:|:|::   |..:.|.||:::.|..:.: |||:.     |...|:..:||.::.
Human   188 LPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPN-VFSMQMCGAGLPVAGSGTNGGSLVL 251

  Fly   231 GGIDRSIYRGCINYVPVSMPAYWQFTANSVKIEGILL---C---NGCQAIADTGTSLIAVPLRAY 289
            |||:.|:|:|.|.|.|:....|:|.....::|.|..|   |   |..:||.|:||:|:.:|.:.:
Human   252 GGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVF 316

  Fly   290 KA-INKVLNAT---DAGDGEAFVDCSSLCRLPNVNLNIGGTTYTLTPKDYIYKVQADNN------ 344
            .| :..|..|:   :..||  |...|.|....|     ..|.::..||..|| ::.:|:
Human   317 DAVVEAVARASLIPEFSDG--FWTGSQLACWTN-----SETPWSYFPKISIY-LRDENSSRSFRI 373

  Fly   345 --------QTLCLSGFTY--------LQGNLLWILGDIFLGKVYTVFDVGKERIGFA 385
                    |.:..:|..|        ...|.| ::|...:...|.:||..::|:|||
Human   374 TILPQLYIQPMMGAGLNYECYRFGISPSTNAL-VIGATVMEGFYVIFDRAQKRVGFA 429

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG6508	NP_609457.1	pepsin_retropepsin_like	68..386	CDD:299705	102/369 (28%)
		Asp	73..387	CDD:278455	100/364 (27%)
BACE2	NP_036237.2	beta_secretase_like	89..450	CDD:133140	100/360 (28%)
		Asp	92..430	CDD:278455	100/357 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151478
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1339
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740