DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6508 and Bace1

DIOPT Version :9

Sequence 1:	NP_609457.1	Gene:	CG6508 / 34493	FlyBaseID:	FBgn0032303	Length:	423	Species:	Drosophila melanogaster
Sequence 2:	NP_035922.4	Gene:	Bace1 / 23821	MGIID:	1346542	Length:	501	Species:	Mus musculus

Alignment Length:	371	Identity:	100/371 - (26%)
Similarity:	166/371 - (44%)	Gaps:	62/371 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    74 YTIRLCIGTPPQCFNLQFDTGSSDLWV-----PSVKCSSTNEACQKHNKYNSSASSSHVEDGKGF 133
            |.:.:.:|:|||..|:..|||||:..|     |.:           |..|....||::.:..||.
Mouse    75 YYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFL-----------HRYYQRQLSSTYRDLRKGV 128

  Fly   134 SIQYGSGSLSGFLSTDTVDI-DGMVIRNQTFAEAIDEPGSAFVN-TIFDGIIGMAFASIS---GG 193
            .:.|..|...|.|.||.|.| .|..:..:....||.|....|:| :.::||:|:|:|.|:   ..
Mouse   129 YVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIARPDDS 193

  Fly   194 VTTPFDNIIRQGLVKHPVFSVYL--------RRDGTSQSGGEVIWGGIDRSIYRGCINYVPVSMP 250
            :...||::::|..:.: :||:.|        :.:..:..||.:|.||||.|:|.|.:.|.|:...
Mouse   194 LEPFFDSLVKQTHIPN-IFSLQLCGAGFPLNQTEALASVGGSMIIGGIDHSLYTGSLWYTPIRRE 257

  Fly   251 AYWQFTANSVKIEGILLCNGC------QAIADTGTSLIAVPLRAYKAINKVLNATDAGDGEAFVD 309
            .|::.....|:|.|..|...|      ::|.|:||:.:.:|.:.::|..|.:.|  |...|.|.|
Mouse   258 WYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKA--ASSTEKFPD 320

  Fly   310 CSSLCR--------------LPNVNLNIGGTT------YTLTPKDYIYKVQ-ADNNQTLCLSGFT 353
            ...|..              .|.::|.:.|..      .|:.|:.|:..|: ...:|..|.. |.
Mouse   321 GFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYK-FA 384

  Fly   354 YLQGNLLWILGDIFLGKVYTVFDVGKERIGFA--KLKKHSSYRVYA 397
            ..|.:...::|.:.:...|.|||..::|||||  ....|..:|..|
Mouse   385 VSQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAA 430

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6508	NP_609457.1	pepsin_retropepsin_like	68..386	CDD:299705	97/358 (27%)
CG6508	NP_609457.1	Asp	73..387	CDD:278455	97/359 (27%)
Bace1	NP_035922.4	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	39..58
		beta_secretase_like	72..437	CDD:133140	100/371 (27%)
		Asp	75..416	CDD:278455	95/355 (27%)
		Interaction with RTN3. /evidence=ECO:0000250	479..501
		DXXLL. /evidence=ECO:0000250\|UniProtKB:P56817	496..500
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167841592
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1339
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S4239
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.690