DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG6508 and BACE1

DIOPT Version :10

Sequence 1:NP_609457.1 Gene:CG6508 / 34493 FlyBaseID:FBgn0032303 Length:423 Species:Drosophila melanogaster
Sequence 2:NP_036236.1 Gene:BACE1 / 23621 HGNCID:933 Length:501 Species:Homo sapiens


Alignment Length:371 Identity:104/371 - (28%)
Similarity:167/371 - (45%) Gaps:62/371 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly    74 YTIRLCIGTPPQCFNLQFDTGSSDLWV-----PSVKCSSTNEACQKHNKYNSSASSSHVEDGKGF 133
            |.:.:.:|:|||..|:..|||||:..|     |.:           |..|....||::.:..||.
Human    75 YYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFL-----------HRYYQRQLSSTYRDLRKGV 128

  Fly   134 SIQYGSGSLSGFLSTDTVDI-DGMVIRNQTFAEAIDEPGSAFVN-TIFDGIIGMAFASIS---GG 193
            .:.|..|...|.|.||.|.| .|..:..:....||.|....|:| :.::||:|:|:|.|:   ..
Human   129 YVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIARPDDS 193

  Fly   194 VTTPFDNIIRQGLVKHPVFSVYLRRDG--TSQS------GGEVIWGGIDRSIYRGCINYVPVSMP 250
            :...||::::|..|.: :||:.|...|  .:||      ||.:|.||||.|:|.|.:.|.|:...
Human   194 LEPFFDSLVKQTHVPN-LFSLQLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRRE 257

  Fly   251 AYWQFTANSVKIEGILLCNGC------QAIADTGTSLIAVPLRAYKAINKVLNATDAGDGEAFVD 309
            .|::.....|:|.|..|...|      ::|.|:||:.:.:|.:.::|..|.:.|  |...|.|.|
Human   258 WYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKA--ASSTEKFPD 320

  Fly   310 CSSLCR--------------LPNVNLNIGGTT------YTLTPKDYIYKVQ-ADNNQTLCLSGFT 353
            ...|..              .|.::|.:.|..      .|:.|:.|:..|: ...:|..|.. |.
Human   321 GFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYK-FA 384

  Fly   354 YLQGNLLWILGDIFLGKVYTVFDVGKERIGFA--KLKKHSSYRVYA 397
            ..|.:...::|.:.:...|.|||..::|||||  ....|..:|..|
Human   385 ISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAA 430

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG6508NP_609457.1 pepsin_retropepsin_like 68..386 CDD:472175 101/358 (28%)
BACE1NP_036236.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 39..58
beta_secretase_like 72..437 CDD:133140 104/371 (28%)
Interaction with RTN3 479..501
DXXLL. /evidence=ECO:0000269|PubMed:15886016 496..500
Blue background indicates that the domain is not in the aligned region.

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