DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6508 and Cym

DIOPT Version :9

Sequence 1:	NP_609457.1	Gene:	CG6508 / 34493	FlyBaseID:	FBgn0032303	Length:	423	Species:	Drosophila melanogaster
Sequence 2:	NP_001104613.1	Gene:	Cym / 229697	MGIID:	2684977	Length:	379	Species:	Mus musculus

Alignment Length:	389	Identity:	141/389 - (36%)
Similarity:	222/389 - (57%)	Gaps:	29/389 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 FLLLLDHSMGQLRRTPITR-QINQNKTHANVKAEKILLAAKYFLVDRQ---SSQTTQV------- 65
            |:||| .::...:...:|| .:::.|:..|...|:.||  :.||..:|   |.:.:::
Mouse     4 FVLLL-AALAISQSHVVTRIPLHKGKSLRNTLKEQGLL--EDFLSRQQYEFSEKNSRIGVVASEP 65

  Fly    66 LANGFNLEYTIRLCIGTPPQCFNLQFDTGSSDLWVPSVKCSSTNEACQKHNKYNSSASSSHVEDG 130
            |.|..:.||...:.||||||.|.:.||||||:||||||.|:|  :.|:.|::::.|.|.:.....
Mouse    66 LINYLDSEYFGTIYIGTPPQEFTVVFDTGSSELWVPSVYCNS--KVCRNHHRFDPSKSITFQNLS 128

  Fly   131 KGFSIQYGSGSLSGFLSTDTVDIDGMVIRNQTFAEAIDEPGSAFVNTIFDGIIGMAFASISGGVT 195
            |...:|||:|.:.|||:.|||.:..:|:.:||...:..|||..|..:.||||:|:|:.:.:...:
Mouse   129 KPLFVQYGTGRMEGFLAYDTVTVSDIVVSHQTVGLSTQEPGDIFTYSPFDGILGLAYPTFASKYS 193

  Fly   196 TP-FDNIIRQGLVKHPVFSVYLRRDGTSQSGGEVIWGGIDRSIYRGCINYVPVSMPAYWQFTANS 259
            .| |||::.:.||...:||||:.|   ::.|..:..|.||:|.:.|.:::|||::..|||||.:.
Mouse   194 VPIFDNMMNRHLVAQDLFSVYMSR---NEQGSMLTLGAIDQSYFIGSLHWVPVTVQGYWQFTVDR 255

  Fly   260 VKIEG-ILLC-NGCQAIADTGTSLIAVPLRAYKAINKVLNATDAGDGEAFVDCSSLCRLPNVNLN 322
            :.|.| ::.| .||.|:.||||:|:..|.|....|.:|:.|....:.:..:||..|..:|.|...
Mouse   256 ITINGEVVACQGGCPAVLDTGTALLTGPGRDILNIQQVIGAVQGHNDQFDIDCWRLDIMPTVVFE 320

  Fly   323 IGGTTYTLTPKDYIYKVQADNNQTLCLSGFTYLQGNLLWILGDIFLGKVYTVFDVGKERIGFAK 386
            |.|..:.|.|..|..:||.     .|.|||.  ||:.:|||||:|:.:.|:|||....|:|.||
Mouse   321 IHGREFPLPPYAYTNQVQG-----FCSSGFK--QGSHMWILGDVFIREFYSVFDRANNRVGLAK 377

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6508	NP_609457.1	pepsin_retropepsin_like	68..386	CDD:299705	123/320 (38%)
CG6508	NP_609457.1	Asp	73..387	CDD:278455	124/317 (39%)
Cym	NP_001104613.1	A1_Propeptide	19..44	CDD:285240	7/26 (27%)
		pepsin_retropepsin_like	64..377	CDD:299705	124/324 (38%)
		Asp	73..378	CDD:278455	124/317 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167841604
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1339
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54317
OrthoDB	1	1.010	-	-		D1619495at2759
OrthoFinder	1	1.000	-	-		FOG0000066
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR47966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.860