DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6508 and Ren2

DIOPT Version :9

Sequence 1:	NP_609457.1	Gene:	CG6508 / 34493	FlyBaseID:	FBgn0032303	Length:	423	Species:	Drosophila melanogaster
Sequence 2:	NP_112470.2	Gene:	Ren2 / 19702	MGIID:	97899	Length:	424	Species:	Mus musculus

Alignment Length:	400	Identity:	158/400 - (39%)
Similarity:	219/400 - (54%)	Gaps:	30/400 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 IPLFLLLLDHS-------MG------QLRRTPITRQINQNKTHANVKAEKILLAAKYFLVDRQSS 60
            :||:.|||..|       .|      .|::.|..|:|.:.:     ..:...|:|::.:..::||
Mouse    29 MPLWALLLLWSPCTFSLPTGTTFERIPLKKMPSVREILEER-----GVDMTRLSAEWDVFTKRSS 88

  Fly    61 QT----TQVLANGFNLEYTIRLCIGTPPQCFNLQFDTGSSDLWVPSVKCSSTNEACQKHNKYNSS 121
            .|    ..||.|..|.:|...:.||||||.|.:.|||||::|||||.|||....||..|:.|.||
Mouse    89 LTDLISPVVLTNYLNSQYYGEIGIGTPPQTFKVIFDTGSANLWVPSTKCSRLYLACGIHSLYESS 153

  Fly   122 ASSSHVEDGKGFSIQYGSGSLSGFLSTDTVDIDGMVIRNQTFAEAIDEPGSAFVNTIFDGIIGMA 186
            .|||::|:|..|:|.||||.:.||||.|:|.:.|:.: .|||.|..:.|...|:...|||::||.
Mouse   154 DSSSYMENGDDFTIHYGSGRVKGFLSQDSVTVGGITV-TQTFGEVTELPLIPFMLAQFDGVLGMG 217

  Fly   187 F-ASISGGVTTPFDNIIRQGLVKHPVFSVYLRRDGTSQSGGEVIWGGIDRSIYRGCINYVPVSMP 250
            | |...||||..||:|:.||::|..|||||..| |....||||:.||.|...|:|..:||.:|..
Mouse   218 FPAQAVGGVTPVFDHILSQGVLKEKVFSVYYNR-GPHLLGGEVVLGGSDPEHYQGDFHYVSLSKT 281

  Fly   251 AYWQFTANSVKI-EGILLC-NGCQAIADTGTSLIAVPLRAYKAINKVLNATDAGDGEAFVDCSSL 313
            ..||.|...|.: ...||| .||:.:.|||:|.|:.|..:.|.|.:.|.|.:....|..|.||.:
Mouse   282 DSWQITMKGVSVGSSTLLCEEGCEVVVDTGSSFISAPTSSLKLIMQALGAKEKRLHEYVVSCSQV 346

  Fly   314 CRLPNVNLNIGGTTYTLTPKDYI--YKVQADNNQTLCLSGFTY-LQGNLLWILGDIFLGKVYTVF 375
            ..||:::.|:||..|||:..||:  |..:.|...|:.|..... .....:|:||..|:.|.||.|
Mouse   347 PTLPDISFNLGGRAYTLSSTDYVLQYPNRRDKLCTVALHAMDIPPPTGPVWVLGATFIRKFYTEF 411

  Fly   376 DVGKERIGFA 385
            |....|||||
Mouse   412 DRHNNRIGFA 421

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6508	NP_609457.1	pepsin_retropepsin_like	68..386	CDD:299705	139/323 (43%)
CG6508	NP_609457.1	Asp	73..387	CDD:278455	137/318 (43%)
Ren2	NP_112470.2	A1_Propeptide	51..76	CDD:285240	4/29 (14%)
		renin_like	98..423	CDD:133154	140/325 (43%)
		Asp	105..423	CDD:278455	137/318 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54317
OrthoDB	1	1.010	-	-		D1619495at2759
OrthoFinder	1	1.000	-	-		FOG0000066
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR47966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	6.030