DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6508 and asp-8

DIOPT Version :9

Sequence 1:	NP_609457.1	Gene:	CG6508 / 34493	FlyBaseID:	FBgn0032303	Length:	423	Species:	Drosophila melanogaster
Sequence 2:	NP_503825.2	Gene:	asp-8 / 178750	WormBaseID:	WBGene00019105	Length:	386	Species:	Caenorhabditis elegans

Alignment Length:	362	Identity:	112/362 - (30%)
Similarity:	174/362 - (48%)	Gaps:	31/362 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 EKILLAAKYFLVDRQSSQTTQVLANG-------FNLEYTIRLCIGTPPQCFNLQFDTGSSDLWVP 101
            |:::...:|    .|.....|.|:.|       |:..||..:.||||.|.|.:.|||.||:|||.
Worm    32 EQLIREGRY----GQELARIQQLSTGNVSFFDHFDEYYTAGVRIGTPAQHFQVAFDTTSSNLWVF 92

  Fly   102 SVKCSSTNEAC-----QKHNKYNSSASSSHVEDGKGFSIQYGSGSLSGFLSTDTVDIDGMVIRNQ 161
            .|:|.|.|  |     ::..:||.:|||:.|.....|::.|..|.:||.:..||....|..|::|
Worm    93 GVECRSQN--CHGGRGRRDREYNRTASSTFVAGTSSFNLPYDGGHVSGNVGKDTAQFAGFTIQSQ 155

  Fly   162 TFAEAIDEPGSAFVNTIFDGIIGMAF-ASISGGVTTPFDNIIRQGLVKHPVFSVYLRR----DGT 221
            .|  .|....:......|||::|:.: |:...|.:|...|::.|  :...:|:.|..:    :||
Worm   156 DF--GIGTAATRLFGETFDGVLGLGWPATALNGTSTTMQNLLPQ--LDQKLFTTYFTKSNMHNGT 216

  Fly   222 SQSGGEVIWGGIDRSIYRGCINYVPVSMPAYWQFTANSVKIEGILLCNGCQAIADTGTSLIAVPL 286
              :||::::|.||.:..:..:||||::..::|.::.:...|...........|.||.:....||.
Worm   217 --AGGDIMFGAIDTTHCQSQVNYVPLAYNSFWSYSVDGFSIGTYSRTQTETTIPDTSSGWTGVPN 279

  Fly   287 RAYKAINKVLNATDAGDGEAF-VDCSSLCRLPNVNLNIGGTTYTLTPKDYIYKVQADNNQ-TLCL 349
            .....|.|...||...:.:|: :.|||...||::...|||.:|.:...:|:..:...|.| .|.|
Worm   280 VVLAGIVKATGATYDWNHQAYTLPCSSTATLPDMVFTIGGNSYNVRAVEYVVNLNLPNGQCALSL 344

  Fly   350 SGFTYLQGNLLWILGDIFLGKVYTVFDVGKERIGFAK 386
            .|....|....|||||.||.....|||.|..|||.||
Worm   345 FGTAASQSGPAWILGDNFLRSYCHVFDFGNSRIGLAK 381

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6508	NP_609457.1	pepsin_retropepsin_like	68..386	CDD:299705	105/336 (31%)
CG6508	NP_609457.1	Asp	73..387	CDD:278455	105/326 (32%)
asp-8	NP_503825.2	pepsin_like	65..381	CDD:133138	103/323 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160162002
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1339
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54317
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000066
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.750