Protein Alignment CG6508 and Ctsd

DIOPT Version :9

• Sequence 1: NP_609457.1
• Gene: CG6508 / 34493
• FlyBaseID: FBgn0032303
• Length: 423
• Species: Drosophila melanogaster
• Sequence 2: NP_599161.2
• Gene: Ctsd / 171293
• RGDID: 621511
• Length: 407
• Species: Rattus norvegicus
• Alignment Length: 399
• Identity: 165/399 - (41%)
• Similarity: 227/399 - (56%)
• Gaps: 21/399 - (5%)

  Fly     8 IIPLFLLLLDHSMGQLRRTPITR--QINQNKTHANVKAEKILLAAKYFLVDRQSSQTT-----QV 65
            ::.|.|.||..|...|.|.|:.:  .|.:..|......|.::|.........|||..|     ::
  Rat     6 VLLLILGLLAASSSALIRIPLRKFTSIRRTMTEVGGSVEDLILKGPITKYSMQSSPRTKEPVSEL 70

  Fly    66 LANGFNLEYTIRLCIGTPPQCFNLQFDTGSSDLWVPSVKCSSTNEACQKHNKYNSSASSSHVEDG 130
            |.|..:.:|...:.||||||||.:.||||||:|||||:.|...:.||..|:||||..||::|::|
  Rat    71 LKNYLDAQYYGEIGIGTPPQCFTVVFDTGSSNLWVPSIHCKLLDIACWVHHKYNSDKSSTYVKNG 135

  Fly   131 KGFSIQYGSGSLSGFLSTDTV------DIDGMVIRNQTFAEAIDEPGSAFVNTIFDGIIGMAFAS 189
            ..|.|.||||||||:||.|||      |:.|:.:..|.|.||..:||..|:...||||:||.:..
  Rat   136 TSFDIHYGSGSLSGYLSQDTVSVPCKSDLGGIKVEKQIFGEATKQPGVVFIAAKFDGILGMGYPF 200

  Fly   190 IS-GGVTTPFDNIIRQGLVKHPVFSVYLRRDGTSQSGGEVIWGGIDRSIYRGCINYVPVSMPAYW 253
            || ..|...|||:::|.||:..:||.||.||.|.|.|||::.||.|...|.|.::|:.|:..|||
  Rat   201 ISVNNVLPVFDNLMKQKLVEKNIFSFYLNRDPTGQPGGELMLGGTDSRYYHGELSYLNVTRKAYW 265

  Fly   254 QFTANSVKI-EGILLC-NGCQAIADTGTSLIAVPLRAYKAINKVLNATDAGDGEAFVDCSSLCRL 316
            |...:.::: ..:.|| .||:||.||||||:..|:...|.:.|.:.|.....||..:.|..:..|
  Rat   266 QVHMDQLEVGSELTLCKGGCEAIVDTGTSLLVGPVDEVKELQKAIGAVPLIQGEYMIPCEKVSSL 330

  Fly   317 PNVNLNIGGTTYTLTPKDYIYKVQADNNQTLCLSGFTYLQ----GNLLWILGDIFLGKVYTVFDV 377
            |.:...:||..|.|.|:.||.|| :...:|:|||||..:.    ...||||||:|:|..|||||.
  Rat   331 PIITFKLGGQNYELHPEKYILKV-SQAGKTICLSGFMGMDIPPPSGPLWILGDVFIGCYYTVFDR 394

  Fly   378 GKERIGFAK 386
            ...|:||||
  Rat   395 EYNRVGFAK 403

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG6508	NP_609457.1	pepsin_retropepsin_like	68..386	CDD:299705	146/330 (44%)
		Asp	73..387	CDD:278455	147/327 (45%)
Ctsd	NP_599161.2	A1_Propeptide	21..46	CDD:285240	6/24 (25%)
		Cathepsin_D2	73..403	CDD:133157	146/330 (44%)
		Asp	78..404	CDD:278455	147/327 (45%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1339
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54317
OrthoDB	1	1.010	-	-		D1619495at2759
OrthoFinder	1	1.000	-	-		FOG0000066
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR47966
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.930