Protein Alignment CG6508 and bace2

DIOPT Version :10

• Sequence 1: NP_609457.1
• Gene: CG6508 / 34493
• FlyBaseID: FBgn0032303
• Length: 423
• Species: Drosophila melanogaster
• Sequence 2: NP_001135590.1
• Gene: bace2 / 100216145
• XenbaseID: XB-GENE-1014090
• Length: 499
• Species: Xenopus tropicalis
• Alignment Length: 362
• Identity: 93/362 - (25%)
• Similarity: 157/362 - (43%)
• Gaps: 62/362 - (17%)

  Fly    71 NLE------YTIRLCIGTPPQCFNLQFDTGSSDLWV-----PSVKCSSTNEACQKHNKYNSSASS 124
            |||      |.:.|.||||||..|:..|||||:..|     |.:.           ..::|..|:
 Frog    66 NLEGDSGRGYYLELLIGTPPQKMNILVDTGSSNFAVAGALNPDIT-----------TFFDSKLST 119

  Fly   125 SHVEDGKGFSIQYGSGSLSGFLSTDTVDIDGMVIRNQTF----AEAIDEPGSAFVNTIFDGIIGM 185
            |:.......:::|..||.:|.|..|.:.:...|  |.||    |...........|..:.||:|:
 Frog   120 SYEPLNTQVTVRYTQGSWTGLLGKDVISMPKGV--NGTFLINIASIFQSENFFLPNINWQGILGL 182

  Fly   186 AFASI---SGGVTTPFDNIIRQGLVKHPVFSVYLRRDGTSQSG-----GEVIWGGIDRSIYRGCI 242
            |::::   |..|...||::::|..:.: :||:.:...|....|     |.::.|||:.|:|:|.|
 Frog   183 AYSTLAKPSSSVEPFFDSLVQQENIPN-IFSMQMCGAGQPSPGIGINAGSLVLGGIEPSLYQGDI 246

  Fly   243 NYVPVSMPAYWQFTANSVKIEGILL---C---NGCQAIADTGTSLIAVPLRAYKAINKVLNATDA 301
            .|.|::...|:|......::.|..|   |   |..:||.|:||:|:.:|.:.:.|:...:..|..
 Frog   247 WYTPITEEWYYQVEVLKFEVGGQNLNLDCTVYNSDKAIVDSGTTLLRLPDKVFNAMVDAIVQTSL 311

  Fly   302 ---GDGEAFVDCSSLC---------RLPNVNLNIGGTT------YTLTPKDYIYKVQADNNQTLC 348
               .:.|.:......|         ..|::::.:..|.      .||.|:.||..|........|
 Frog   312 IQNFNAEFWAGLQLACWDKTQDPWNYFPDISIYLRDTNSSRSFRLTLKPQLYIQSVLTFQESLNC 376

  Fly   349 LSGFTYLQGNLLWILGDIFLGKVYTVFDVGKERIGFA 385
            .. |...|.....::|...:...|.:||..::|:|||
 Frog   377 FR-FGISQSASALVIGATVMEGFYVIFDRAEKRVGFA 412

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG6508	NP_609457.1	pepsin_retropepsin_like	68..386	CDD:472175	93/362 (26%)
bace2	NP_001135590.1	beta_secretase_like	72..433	CDD:133140	90/356 (25%)