DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6724 and WDR12

DIOPT Version :9

Sequence 1:	NP_609452.1	Gene:	CG6724 / 34488	FlyBaseID:	FBgn0032298	Length:	420	Species:	Drosophila melanogaster
Sequence 2:	NP_060726.3	Gene:	WDR12 / 55759	HGNCID:	14098	Length:	423	Species:	Homo sapiens

Alignment Length:	411	Identity:	172/411 - (41%)
Similarity:	256/411 - (62%)	Gaps:	11/411 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 QVQVHLKTKQEHYAVPDVPYAIDGTVTTVELNTFVNALLRQK-DGSSDTDFDFLVFDEYLRGRLC 72
            |:|....|..:.|||.|||::|.......:|:..:|.||:.| :.....:||||:..::||..|.
Human     3 QLQTRFYTDNKKYAVDDVPFSIPAASEIADLSNIINKLLKDKNEFHKHVEFDFLIKGQFLRMPLD 67

  Fly    73 DHLREKAISFEDAIEIEYVERFPAPEPQDCLLHDDWVSAVKARGKWILSGCYDNTLNLWTNKGKH 137
            .|:..:.||.|:.:||||||::.||:|:.|:.||||:|::|...:|||:|.||.|..:|:.:||.
Human    68 KHMEMENISSEEVVEIEYVEKYTAPQPEQCMFHDDWISSIKGAEEWILTGSYDKTSRIWSLEGKS 132

  Fly   138 ILTISGHTAPIKAVDWISLDEETGRFVSTSQDQTAMLWQWNVGSNSVECVSVCKGHERGVDSVSV 202
            |:||.|||..:|.|.|:..|..:...:|.|.|||.:||:|||..|.|:.:..|:||...|||::|
Human   133 IMTIVGHTDVVKDVAWVKKDSLSCLLLSASMDQTILLWEWNVERNKVKALHCCRGHAGSVDSIAV 197

  Fly   203 SPDGLRFATGSWDTMLKVWS---AELDDAVEGSSKRMKESG-------VRTPKITLQGHRESVSA 257
            ...|.:|.:||||.|||:||   .:.:|.:|.|:.|.::..       .|||.:||.||.|:||:
Human   198 DGSGTKFCSGSWDKMLKIWSTVPTDEEDEMEESTNRPRKKQKTEQLGLTRTPIVTLSGHMEAVSS 262

  Fly   258 VQWMDATTLLTGSWDHTLKVWDLSLEGIKTEISTNKSIFDASYSKLNRLILTASADKNLRLYDPR 322
            |.|.||..:.:.|||||::|||:....:|:.::.||.....|||.|.:.:.:.|.|:::||:|||
Human   263 VLWSDAEEICSASWDHTIRVWDVESGSLKSTLTGNKVFNCISYSPLCKRLASGSTDRHIRLWDPR 327

  Fly   323 TNQGSVVRNTYLGHNAWVQTVMWSTTEEFLFVSGAYDNQNKLWDCRSPKAPLYDLLGHGEKVLDI 387
            |..||:|..:...|..||.:|.||.|.|...:||:.||..||||.||.|||||||..|.:|||.:
Human   328 TKDGSLVSLSLTSHTGWVTSVKWSPTHEQQLISGSLDNIVKLWDTRSCKAPLYDLAAHEDKVLSV 392

  Fly   388 DWSNPKYIVSGGVDNTVRVFK 408
            ||::...::|||.||.:..::
Human   393 DWTDTGLLLSGGADNKLYSYR 413

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6724	NP_609452.1	NLE	10..75	CDD:285380	21/65 (32%)
		WD40	105..>411	CDD:225201	136/314 (43%)
		WD40	105..408	CDD:238121	136/312 (44%)
		WD40 repeat	198..250	CDD:293791	23/61 (38%)
		WD40 repeat	255..288	CDD:293791	15/32 (47%)
		WD40 repeat	296..333	CDD:293791	15/36 (42%)
		WD40 repeat	340..378	CDD:293791	22/37 (59%)
WDR12	NP_060726.3	Ubiquitin-like (UBL) domain. /evidence=ECO:0000255\|HAMAP-Rule:MF_03029	4..87		29/82 (35%)
		NLE	4..70	CDD:369718	21/65 (32%)
		Sufficient for nucleolar localization	98..423		136/316 (43%)
		WD40	100..409	CDD:238121	136/308 (44%)
		WD40 repeat	193..255	CDD:293791	23/61 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	220..242		4/21 (19%)
		WD40 repeat	260..295	CDD:293791	15/34 (44%)
		WD40 repeat	301..338	CDD:293791	15/36 (42%)
		WD40 repeat	345..383	CDD:293791	22/37 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147732
Domainoid	1	1.000	77	1.000	Domainoid score	I8913
eggNOG	1	0.900	-	-		E1_KOG0313
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H10098
Inparanoid	1	1.050	363	1.000	Inparanoid score	I2187
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53844
OrthoDB	1	1.010	-	-		D1540178at2759
OrthoFinder	1	1.000	-	-		FOG0005032
OrthoInspector	1	1.000	-	-		oto90434
orthoMCL	1	0.900	-	-		OOG6_102659
Panther	1	1.100	-	-	LDO	PTHR19855
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2900
SonicParanoid	1	1.000	-	-		X3556
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800