DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6495 and LRP11

DIOPT Version :9

Sequence 1:	NP_609451.1	Gene:	CG6495 / 34486	FlyBaseID:	FBgn0027550	Length:	675	Species:	Drosophila melanogaster
Sequence 2:	NP_116221.3	Gene:	LRP11 / 84918	HGNCID:	16936	Length:	500	Species:	Homo sapiens

Alignment Length:	753	Identity:	144/753 - (19%)
Similarity:	210/753 - (27%)	Gaps:	373/753 - (49%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 ALPFLLMIAEAAATAEQV-KYLEYLQSSPAEHRLSKRMDLEV---------C----IGHFDVHKN 56
            |||....::|..|....| :.||..:....:.|..:.::||:         |    .|.:....:
Human    38 ALPPAAPLSELHAQLSGVEQLLEEFRRQLQQERPQEELELELRAGGGPQEDCPGPGSGGYSAMPD 102

  Fly    57 TIIRTGESQAIGGKYLQG-IELDTIEECERLCCETDACDVYIFE---RKA------GGYCYLFEC 111
            .||||.:|.|.|..:|:. ..:....:|...||....|.|.:.|   |.|      |  ||||.|
Human   103 AIIRTKDSLAAGASFLRAPAAVRGWRQCVAACCSEPRCSVAVVELPRRPAPPAAVLG--CYLFNC 165

  Fly   112 GPPEDFRCKFTRHANYTSAVLNPQPKPVGELVTTPR---------PQLP--------HIPSNNV- 158
            .......|||..|:.|:|..|:..|.  |..:.|.|         |.|.        |:|::.|
Human   166 TARGRNVCKFALHSGYSSYSLSRAPD--GAALATARASPRQEKDAPPLSKAGQDVVLHLPTDGVV 228

  Fly   159 ------------SQQEWEL------SNLK------LKPEARDKPTVSTAAVVAPTSGTGTGTGVG 199
                        .|.||.|      .::|      ||.....:.|.:....|..|:|..:...|.
Human   229 LDGRESTDDHAIVQYEWALLQGDPSVDMKVPQSGTLKLSHLQEGTYTFQLTVTDTAGQRSSDNVS 293

  Fly   200 LGVGQSPVYQSQSVPAAH--------CGRFQFTCHSGECIAVYNACDGIPQCEDGSDE------G 250
            :.|          :.||:        |.|:.|.|..|.||.:..||||:.||.|||||      |
Human   294 VTV----------LRAAYSTGGCLHTCSRYHFFCDDGCCIDITLACDGVQQCPDGSDEDFCQNLG 348

  Fly   251 PECNIVLSTATKPATTSSNLEPVKPMVSQYVPVQNVQQTQQVVAQQMQQQQPQQQQQQPQQQPQH 315
            .:..:|..||..||.
Human   349 LDRKMVTHTAASPAL-------------------------------------------------- 363

  Fly   316 VIVLGPPPPPPPPPPMVNNREDAAAWANRKMIAEGQQQLPQQQLQQQQQQQSSQPKTEIINTDAQ 380
                                                                  |:|
Human   364 ------------------------------------------------------PRT-------- 366

  Fly   381 SHIFSHKGGLQLQQPANGQGPPPSPLQVPGQMAGAGQVQVQGQSPTLQLPGYEANQAVYGMSRTG 445
                            .|          |.:.||...:..:.|..|
Human   367 ----------------TG----------PSEDAGGDSLVEKSQKAT------------------- 386

  Fly   446 IYMPQQPAQLQAPAGQQQQQVQASVVWPQQAPLIPQQQSPVQQSQSLMPQQSGHVYAAAAPAIQS 510
              .|.:|     ||....::...|..|..::.:||           :||..|.
Human   387 --APNKP-----PALSNTEKRNHSAFWGPESQIIP-----------VMPDSSS------------ 421

  Fly   511 PPAAQQAMLPVLNAAPVAGKNQGPAADGDYDDYDEETYTEAPKKKQHKHKKVKTKTAKDPIELAL 575
                             :|||:           .||:|
Human   422 -----------------SGKNR-----------KEESY--------------------------- 431

  Fly   576 EQNKLQPEGSLPALPVPASPVHEQYKMIHDNLAMEFRDHDGHSERPG---GAVLSLTLGLLVTAA 637
                                            ..|.:...|..|.|.   ||||.|.|||.:||.
Human   432 --------------------------------IFESKGDGGGGEHPAPETGAVLPLALGLAITAL 464

  Fly   638 LAILIGCRMRTVTRRARRLGGKTPYSQEADFLVNGMYL 675
            |.:::.||:|.|.::.::....|  |:|:|:|:|||||
Human   465 LLLMVACRLRLVKQKLKKARPIT--SEESDYLINGMYL 500

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6495	NP_609451.1	MANEC	47..129	CDD:284837	29/95 (31%)
CG6495	NP_609451.1	LDLa	218..249	CDD:238060	16/30 (53%)
LRP11	NP_116221.3	MANEC	84..184	CDD:129004	29/101 (29%)
		PKD	208..296	CDD:238084	17/87 (20%)
		LDLa	310..344	CDD:238060	18/33 (55%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	358..445		31/360 (9%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	127	1.000	Inparanoid score	I4696
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005567
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR46876
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5879
SonicParanoid	1	1.000	-	-		X5981
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	7	7.050