Protein Alignment CG6495 and SPINT1

DIOPT Version :10

• Sequence 1: NP_609451.1
• Gene: CG6495 / 34486
• FlyBaseID: FBgn0027550
• Length: 675
• Species: Drosophila melanogaster
• Sequence 2: NP_857593.1
• Gene: SPINT1 / 6692
• HGNCID: 11246
• Length: 529
• Species: Homo sapiens
• Alignment Length: 306
• Identity: 65/306 - (21%)
• Similarity: 89/306 - (29%)
• Gaps: 115/306 - (37%)

  Fly    58 IIRTGESQAIGGKYLQGIELDTIEECERLCCETDACDVYIFE------RKAGGYCYLFECGPPED 116
            ::.|..|.:.|..:|:...:....:|.|.||.|..|::.:.|      ..|...|:|..|...::
Human    62 VLDTNASVSNGATFLESPTVRRGWDCVRACCTTQNCNLALVELQPDRGEDAIAACFLINCLYEQN 126

  Fly   117 FRCKF----------TRHANYTSAVLNPQ-------PKPVGELVTTPRPQLPHIPSNNVSQQEW- 163
            |.|||          ||....:...|..|       ||....:....:||.| :...:|...:|
Human   127 FVCKFAPREGFINYLTREVYRSYRQLRTQGFGGSGIPKAWAGIDLKVQPQEP-LVLKDVENTDWR 190

  Fly   164 ------------------ELSNLK-------LKPEARDKP--TVSTAAVVAPTSGTG----TGTG 197
                              ||..||       |...:.|.|  |.:....|..|..|.    ....
Human   191 LLRGDTDVRVERKDPNQVELWGLKEGTYLFQLTVTSSDHPEDTANVTVTVLSTKQTEDYCLASNK 255

  Fly   198 VGLGVGQSP--------------VY---------------------------------------Q 209
            ||...|..|              ||                                       |
Human   256 VGRCRGSFPRWYYDPTEQICKSFVYGGCLGNKNNYLREEECILACRGVQGGPLRGSSGAQATFPQ 320

  Fly   210 SQSVPAAH------CGRFQFTCHSGECIAVYNACDGIPQCEDGSDE 249
            ..|:...|      |...||.|.:|.||..:..||..|.|.|.|||
Human   321 GPSMERRHPVCSGTCQPTQFRCSNGCCIDSFLECDDTPNCPDASDE 366

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG6495	NP_609451.1	MANEC	42..130	CDD:129004	21/87 (24%)
		LDLa	218..249	CDD:238060	13/30 (43%)
SPINT1	NP_857593.1	MANEC	50..139	CDD:462186	19/76 (25%)
		Kunitz_HAI1_1-like	245..303	CDD:438666	7/57 (12%)
		LDLa	334..366	CDD:197566	13/31 (42%)
		Kunitz_HAI1_2-like	390..450	CDD:438667