Protein Alignment CG6729 and smg-8

DIOPT Version :10

• Sequence 1: NP_609449.1
• Gene: CG6729 / 34484
• FlyBaseID: FBgn0032296
• Length: 944
• Species: Drosophila melanogaster
• Sequence 2: NP_497003.3
• Gene: smg-8 / 175103
• WormBaseID: WBGene00010551
• Length: 873
• Species: Caenorhabditis elegans
• Alignment Length: 1014
• Identity: 222/1014 - (21%)
• Similarity: 394/1014 - (38%)
• Gaps: 268/1014 - (26%)

  Fly    23 QLNGSLVVVGIVGRSDCDQANKMVAFGMEPPSEHTPKDGQMQCYYKPG----------TSILLLH 77
            ||:..:.|:|::|:...|..                |...:.||.:..          |..:..|
 Worm    17 QLDTKIKVIGVIGKDYPDHG----------------KGDNINCYLRENVFPVAATEDETCTIRGH 65

  Fly    78 FESTYDAEIAGQMIDVCIEDVDTPFDI---------DSFFEGI---RCRFVRMMLLALHVCHIVV 130
            |...      .|::.:.:..||...:|         .::|:.:   .|:.:||:......||.::
 Worm    66 FSED------DQILFLVMNGVDDVANIRKCLKSNPKSNYFDAMAESECQQIRMLHFLFISCHFII 124

  Fly   131 YVETGQTFDPTLITVFQLAKFAREQHLMQFLPQMLRETPAARMS----------ERTRLCTPRIL 185
            ..|.....|..|:...:....||.| |.:.:.|.|..:....:|          ...|:..||:|
 Worm   125 IFEQTSRIDLELMRFLKKVNSARIQ-LRKKINQRLVASDLRDVSFNNRILSSAESEGRMVVPRLL 188

  Fly   186 FLFE--NFPSD----EPKTRECVSTYEFQMEDCIYELLRHHNIVTNSSSNSLVALPNNKQFVFFN 244
            ..|:  |...|    :...||.....|..:::...::|:.:::: :..::||..|
 Worm   189 IAFQRNNIRPDVNPGKKLQRELYEKLEKNLDNQFSDILKLYDLI-DCGASSLCQL---------- 242

  Fly   245 AHEELREDTLMKAVECLNETMYKPD--------LKEEEEDLEILALAPFDGFVKPFALPVDEKEW 301
                   :..:..|..||..:.|.|        |..:.|:.:|...|.        .||
 Worm   243 -------NETIPVVHLLNPKIVKRDIIGEMFEILMADAENTKISGNAG--------TLP------ 286

  Fly   302 DNQQYKKDHTVWNFLERHVQDALMGCFEAGSFKQHAQQGTFQLLNSKEWHDCMATMHTLLVENTK 366
            .|..:.|      |||.:.:               :::....|.|..|..:|:        :...
 Worm   287 SNNSFVK------FLEDNFR---------------SEKNEISLENVIELMNCL--------QCVL 322

  Fly   367 DPNLETSNEE--YKNFLKNF-DESLNYEKKFWAHLCELGLKKGIAAYKNAAPE-----------N 417
            |.:||..:|:  .:.|:|.. ::.:...::.:.:....|.::|...:|::...           .
 Worm   323 DGDLEEKHEKTAIQTFIKRIQNDHMEEARRLYTNAQRPGERRGADRFKDSEKPVKIRSKEEHLMR 387

  Fly   418 YGSATHRQLLAEATLAFEEEGRGPQAQAALAKLASICHKHWQDGRQQCEQLSL-------RSHPC 475
            :..|||          :.:...|..::.||::|.:.|::.||...:.||.:|:       :.||.
 Worm   388 FNEATH----------YIDSVVGVNSREALSQLQAQCNEMWQSDMRACESVSMMGRSCVRKIHPT 442

  Fly   476 TLPKKVPHEK---HNSGVIHISSCNCGRTQGRREDPFNLRQANYEFYEHIAQMCNLCVKVKQYQF 537
            ...:..|..:   |::....||:|.|||.|..|.:||::::||.:||:|....|  |.::.:|||
 Worm   443 FGDQTAPEHRWTAHDASNTMISTCVCGRKQLIRPEPFSVKEANSDFYDHPDFKC--CRRLWRYQF 505

  Fly   538 PIFEPSVSDYRAAAFEAAFPLLNNGKSGAPQDEDAEEDE-------------AEEEEGQEQEQPT 589
            .:::                            ||:||.:             |.::..|.:::..
 Worm   506 QLYQ----------------------------EDSEEKDDIMWADRESNSLRAAKKMAQREDELA 542

  Fly   590 EEQLQNTASNCCSQPLSPTFGSDLNMSIAGFGASLKESQASSEQLLNSEQNTTSSGTSSADTDNE 654
            ||............|.|.:...:.::.:....:|...||.|...|..:.:...|   .::.|:.|
 Worm   543 EEDTDLDIPESLLDPDSTSPSDEDDVRVRTMSSSESSSQESDAYLRPTSRRDES---MASKTERE 604

  Fly   655 LVVELQEPAKKEAREDAGPAHAVSTSTTEYLPGLVHTVSNFGLLPLFPSWSLACVGPSSIYSHNT 719
            |.::  ...:.:..|.||       .:.::|..:.::::. |.||:||||.|..:|.||||||..
 Worm   605 LTID--HVKRMQKLELAG-------KSEDFLITVPNSMTT-GKLPIFPSWHLTSLGDSSIYSHGA 659

  Fly   720 GLQEHFQSGFLSGANFLLP----WDVQLRLVHAPKQQYQQQHHGKKQQRWKKQGDRLSLKIFVGM 780
            ||:.  |..|..|.::|.|    .||...:.:....:.:.:...:|..:..|. |...:|:|||.
 Worm   660 GLKN--QPNFKIGGDYLSPVVVLLDVNFDVWNRDLNKIRSEDFSRKCGKDNKD-DSARVKLFVGF 721

  Fly   781 EYECSRGHRFMM---------CAPDRVLRGGADIERETCSMVVHNNMPLYYPCPCRSQNNFLAQL 836
            ||||||||||.:         .....|:|..|  .|.:...|:..::|:..||.||......|||
 Worm   722 EYECSRGHRFFVDYNGEPLIYSKGSNVIRESA--HRSSLGNVLQADLPIRRPCTCRKLPLQSAQL 784

  Fly   837 MRIHVVTPKAPVNIIVDPKVCVGRYTFTMGSIVPP-RLSQSAYWIIRLPYVYQGDDVLIAPPEQL 900
            .::|||||||||:|.:||||.:..:....|:...| .|..|.|:|:.||.||.|
 Worm   785 QKVHVVTPKAPVHITIDPKVLIPTHEGVYGTGQEPLELHHSKYYILHLPTVYSG----------- 838

  Fly   901 DPGYPLTGGYLLPGMFGVVETDPTLDLNEPDKMGASAAG 939
                  ..|..:||.|            .|:|.|....|
 Worm   839 ------PSGAWMPGEF------------NPEKQGVWMGG 859

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG6729	NP_609449.1	Smg8_Smg9	23..915	CDD:463005	216/988 (22%)
smg-8	NP_497003.3	Smg8_Smg9	17..860	CDD:463005	222/1014 (22%)