DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG12299 and ZNF516

DIOPT Version :9

Sequence 1:NP_609448.1 Gene:CG12299 / 34483 FlyBaseID:FBgn0032295 Length:736 Species:Drosophila melanogaster
Sequence 2:NP_055458.1 Gene:ZNF516 / 9658 HGNCID:28990 Length:1163 Species:Homo sapiens


Alignment Length:596 Identity:121/596 - (20%)
Similarity:190/596 - (31%) Gaps:205/596 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly   284 CSICQKTFTHIGSLNTHIRIHSGEKPYKCELCPKAFTQSSSLMVHMRSHSVRKPHQCVQCDKGFI 348
            |.||.|:|....||:.|:|.|:|||||||..|....:|..:|.:|:|||......|..:.:.|..
Human    36 CCICGKSFPFQSSLSQHMRKHTGEKPYKCPYCDHRASQKGNLKIHIRSHRTGTLIQGHEPEAGEA 100

  Fly   349 NYSSLLLHQKTHIAPTETFICPECEREFKAEALLDEHMRMH------------------------ 389
            ....:...:......:.|.....|.|.....:..|....::                        
Human   101 PLGEMRASEGLDACASPTKSASACNRLLNGASQADGARVLNGASQADSGRVLLRSSKKGAEGSAC 165

  Fly   390 ---TQELVYQCAICREAFRASSELVQHMKNHMGEKPFTCSLCDRSFTQSGSLNIHM-RIH----- 445
               ..:...||:.|:..|....:|..|:  |...|||.|.||..:..:..||..|: |.|     
Human   166 APGEAKAAVQCSFCKSQFERKKDLELHV--HQAHKPFKCRLCSYATLREESLLSHIERDHITAQG 228

  Fly   446 --TGE------KP------FQCKLCDKCFTQASSLSVHMKIHAGEKPYPCPICGKSYSQQAYLNK 496
              :||      ||      |.|::|.:.|:|...|..|||.|.|...:.|.|||:.:.:..:|..
Human   229 PGSGEACVENGKPELSPGEFPCEVCGQAFSQTWFLKAHMKKHRGSFDHGCHICGRRFKEPWFLKN 293

  Fly   497 HIQAHQMASAA----SASTSPGLLVAKQPHETL---------VCIVCGSLHADATALASH--VHS 546
            |::||...:.:    .:...|...:.....|.:         ||..||:|..:..:|.:|  :|.
Human   294 HMKAHGPKTGSKNRPKSELDPIATINNVVQEEVIVAGLSLYEVCAKCGNLFTNLDSLNAHNAIHR 358

  Fly   547 QHAA-----------------------LLDTMKQSGMNTAPG----------------------- 565
            :..|                       .|:....:..::.||                       
Human   359 RVEASRTRAPAEEGAEGPSDTKQFFLQCLNLRPSAAGDSCPGTQAGRRVAELDPVNSYQAWQLAT 423

  Fly   566 -GAIPD----VKCSA------------EEQQAYVERVQCVLQQMNHQQQHQQHQQQPPQQQQQHP 613
             |.:.:    :|..|            ::::.||    .|.|:...::|.....|.||:::...|
Human   424 RGKVAEPAEYLKYGAWDEALAGDVAFDKDRREYV----LVSQEKRKREQDAPAAQGPPRKRASGP 484

  Fly   614 -QQQQQQHLQQQP------------------------------HQMQL----------------- 630
             ......||..:.                              |||.|                 
Human   485 GDPAPAGHLDPRSAARPNRRAAATTGQGKSSECFECGKIFRTYHQMVLHSRVHRRARRERDSDGD 549

  Fly   631 ---------------PQQPKLP-----AMDSTGE---DEEEPDEAEEPPDEEEEQDEPEE---PA 669
                           ..||..|     |.||.|.   ||...|..||...|.....:|..   ..
Human   550 RAARARCGSLSEGDSASQPSSPGSACAAADSPGSGLADEAAEDSGEEGAPEPAPGGQPRRCCFSE 614

  Fly   670 EVKTEVLAAED 680
            ||.:..|::.|
Human   615 EVTSTELSSGD 625

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG12299NP_609448.1 COG5048 <254..413 CDD:227381 35/155 (23%)
C2H2 Zn finger 256..276 CDD:275368
zf-H2C2_2 268..293 CDD:290200 5/8 (63%)
C2H2 Zn finger 284..304 CDD:275368 9/19 (47%)
zf-H2C2_2 296..321 CDD:290200 13/24 (54%)
zf-C2H2_2 312..>387 CDD:289522 14/74 (19%)
C2H2 Zn finger 312..332 CDD:275368 6/19 (32%)
C2H2 Zn finger 340..360 CDD:275368 1/19 (5%)
C2H2 Zn finger 369..389 CDD:275368 3/19 (16%)
C2H2 Zn finger 397..417 CDD:275368 5/19 (26%)
zf-H2C2_2 409..434 CDD:290200 9/24 (38%)
C2H2 Zn finger 425..445 CDD:275368 7/20 (35%)
zf-H2C2_2 437..462 CDD:290200 13/44 (30%)
C2H2 Zn finger 453..473 CDD:275368 8/19 (42%)
zf-H2C2_2 465..490 CDD:290200 10/24 (42%)
C2H2 Zn finger 481..501 CDD:275368 6/19 (32%)
ZNF516NP_055458.1 Mediates promoter DNA-binding and activation of transcription. /evidence=ECO:0000250|UniProtKB:Q7TSH3 1..431 86/396 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..26
COG5048 32..>90 CDD:227381 24/53 (45%)
zf-C2H2 34..56 CDD:278523 9/19 (47%)
C2H2 Zn finger 36..56 CDD:275368 9/19 (47%)
zf-H2C2_2 48..73 CDD:290200 13/24 (54%)
C2H2 Zn finger 64..84 CDD:275368 6/19 (32%)
C2H2 Zn finger 176..194 CDD:275368 5/19 (26%)
C2H2 Zn finger 202..223 CDD:275368 7/20 (35%)
C2H2 Zn finger 250..270 CDD:275368 8/19 (42%)
C2H2 Zn finger 278..298 CDD:275368 6/19 (32%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 460..512 8/51 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 533..667 18/93 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 679..730
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 838..1007
zf-C2H2 1098..1120 CDD:278523
C2H2 Zn finger 1100..1120 CDD:275368
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1126..1163
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 1 0.950 - 0 Normalized mean entropy S6442
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.950

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